Effects of single-dose injectable paracetamolversus propacetamol in pain management after minor gynecologic surgery: A multicenter, randomized, double-blind, active-controlled, two-parallel-group study

Marty, J.; Benhamou, Dan; Chassard, D.; Emperaire, Nicole; Roche, Alain; Mayaud, A.; Haro, D; Baron, Xavier; Hiesse-Provost, Odile

doi:10.1016/j.curtheres.2005.08.007

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…Previous trials have shown bioequivalence of paracetamol 1 g and propacetamol 2 g [6, 37]. Head‐to‐head trials of intravenous paracetamol vs. intravenous propacetamol have shown no differences in the proportion of participants achieving at least 50% pain relief during 4 postoperative hours [6, 36, 38, 39]. Only one included trial gave propacetamol compared with five doses of oral paracetamol [31].…”

Section: Discussionmentioning

confidence: 99%

“…postoperative hours [6,36,38,39]. Only one included trial gave propacetamol compared with five doses of oral paracetamol [31].…”

Section: Discussionmentioning

confidence: 99%

“…propacetamol have shown no differences in the proportion of participants achieving at least 50% pain relief during 4 postoperative hours [6,36,38,39]. Only one included trial gave propacetamol compared with five doses of oral paracetamol [31].…”

Section: Most Of the Included Trials Gave Paracetamolmentioning

confidence: 99%

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A systematic review and trial sequential analysis of intravenous vs. oral peri‐operative paracetamol

et al. 2020

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Summary Postoperative pain might be different after intravenous vs. oral paracetamol. We systematically reviewed randomised controlled trials in patients >15 years that compared intravenous with oral paracetamol for postoperative pain. We identified 14 trials with 1695 participants. There was inconclusive evidence for an effect of route of paracetamol administration on postoperative pain at 0–2 h (734 participants), 2–6 h (766 participants), 6–24 h (1115 participants) and >24 h (248 participants), with differences in standardised mean (95%CI) pain scores for intravenous vs. oral of −0.17 (−0.45 to 0.10), −0.09 (−0.24 to 0.06), 0.06 (−0.12 to 0.23) and 0.03 (−0.22 to 0.28), respectively. Trial sequential analyses suggested that a total of 3948 participants would be needed to demonstrate a meaningful difference in pain or its absence at 0–2 h. There were no differences in secondary outcomes. Intravenous paracetamol is more expensive than oral paracetamol. Substitution of oral paracetamol in half the patients given intravenous paracetamol in our hospital would save around £ 38,711 (€ 43,960 or US$ 47,498) per annum.

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Section: Discussionmentioning

confidence: 99%

“…postoperative hours [6,36,38,39]. Only one included trial gave propacetamol compared with five doses of oral paracetamol [31].…”

Section: Discussionmentioning

confidence: 99%

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A systematic review and trial sequential analysis of intravenous vs. oral peri‐operative paracetamol

et al. 2020

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“…More acetaminophen patients were also willing to receive the same treatment again (96% vs 81%, P = .005). 27…”

Section: Comparative Efficacymentioning

confidence: 99%

Acetaminophen Intravenous

Cada¹,

Levien

Baker

2011

Hosp Pharm

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Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. Subscribers to The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The April 2011 monograph topics are on vilazodone hydrochloride, hydroxyprogesterone caproate, gabapentin extended-release, spinosad 0.9% topical suspension, and aclidinium bromide. The DUE/MUE is on pegloticase.

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“…13 Pain relief is reached within 15 minutes of intravenous acetaminophen, 13,14 and it has been effective in controlling pain and reducing the need for narcotics in postoperative patients. [15][16][17][18][19][20][21] Clinical and anecdotal evidence demonstrates a greater analgesic effect for intravenous administration. 14 The goal of analgesia in labor is to reduce pain while minimizing both maternal and fetal adverse effects.…”

mentioning

confidence: 99%

Intravenous Acetaminophen versus Morphine for Analgesia in Labor: A Randomized Trial

et al. 2016

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To compare the effectiveness of intravenous acetaminophen with that of morphine in reducing pain in the first stage of labor. An open-label, randomized controlled trial of women ≥ 34 weeks gestation in the first stage of labor, assigned to either intravenous acetaminophen or morphine. The primary outcome was improved analgesia measured by difference of visual analog scale (VAS) score at 120 minutes from baseline. Secondary outcomes were request for rescue analgesia, maternal side effects, and fetal heart rate changes. Statistical analyses performed were chi-square, Student's-test, and Kaplan-Meier survival analysis. Of 40 women randomized, 18 received acetaminophen (2 did not receive study drug), and 20 received morphine. Because of difficulties in recruitment, the sample size of 88 was not achieved. The primary outcome was similar between groups ( = 0.53). Within 120 minutes of initial treatment, more women receiving intravenous acetaminophen required rescue analgesia (acetaminophen: 52.9% vs. morphine: 17.6%, < 0.01). Maternal and fetal side effects were similar between groups. There was no difference in VAS scores between groups. However, as half of women receiving intravenous acetaminophen required rescue analgesia within 120 minutes of treatment, intravenous acetaminophen may be less effective for analgesia in early labor compared with intravenous morphine.

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Effects of single-dose injectable paracetamolversus propacetamol in pain management after minor gynecologic surgery: A multicenter, randomized, double-blind, active-controlled, two-parallel-group study

Abstract: In these patients with moderate to severe pain after minor gynecologic surgery, a single dose of IV-APAP was associated with better local tolerability, similar analgesic efficacy, and greater patient satisfaction compared with a single bioequivalent dose of ProAPAP.

Cited by 10 publications

References 11 publications

A systematic review and trial sequential analysis of intravenous vs. oral peri‐operative paracetamol

A systematic review and trial sequential analysis of intravenous vs. oral peri‐operative paracetamol

Acetaminophen Intravenous

Intravenous Acetaminophen versus Morphine for Analgesia in Labor: A Randomized Trial

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