Effects of Single or Repeated Immobilization on Release of Norepinephrine and Its Metabolites in the Central Nucleus of the Amygdala in Conscious Rats

Pacák, Karel; Palkóvits, M.; Květňanský, Richard; Fukuhara, Kazunobu; Armando, Inés; Kopin, Irwin J.; Goldstein, David S.

doi:10.1159/000126417

Cited by 65 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of studies indicate that exposure to stressful stimuli activates NE terminals in the AMG [4]. For example, some experiments have demonstrated that immobilization increases synthesis, release, and metabolism of NE in the AMG in conscious rats [41,42]. The mechanism by which NE in the AMG activates the HPA axis following photic stimulation is not entirely clear.…”

Section: The Role Of Central Neurotransmiters In Mediating the Efect mentioning

confidence: 99%

The Role of the Amygdala in Regulating the Hypothalamic-Pituitary-Adrenal Axis

Weidenfeld¹,

Ovadia²

2017

The Amygdala - Where Emotions Shape Perception, Learning and Memories

View full text Add to dashboard Cite

We investigated the regulatory role of the amygdala upon the function of the hypothalamic-pituitary-adrenal (HPA) axis as measured by median eminence corticotrophin releasing hormone (CRH) content and serum levels of adrenocorticotrophic hormone (ACTH) and corticosterone. Our indings showed that (1) lesions of the central amygdala inhibited the HPA axis responses to a variety of stressful stimuli. (2) Depletion of norepinephrine or serotonin in the amygdala and hypothalamus and local injections of norepinephrine and serotonin receptor antagonists into the central amygdala inhibited the HPA axis responses to neural stress. Norepinephrine and serotonin agonists injected into the amygdala caused an increase in HPA axis activity. The activation of the amygdala facilitated the in vivo release of serotonin from the paraventricular nucleus following electrical stimulation of the brainstem raphe nuclei. (3) Electrical stimulation of the amygdala impaired the glucocorticoid negative feedback action following neural stressful stimuli probably via a decrease in hippocampal corticosteroid receptors.

show abstract

Section: The Role Of Central Neurotransmiters In Mediating the Efect mentioning

confidence: 99%

The Role of the Amygdala in Regulating the Hypothalamic-Pituitary-Adrenal Axis

Weidenfeld¹,

Ovadia²

2017

The Amygdala - Where Emotions Shape Perception, Learning and Memories

View full text Add to dashboard Cite

show abstract

“…The ascending noradrenergic system is activated by stress (Abercrombie and Jacobs 1987;Morilak et al 1987;Pacak et al 1993), and it has been demonstrated that stress-induced activation of the noradrenergic input to BSTL can facilitate both behavioral reactivity and activation of the HPA axis in response to stress (Cecchi et al 2001; Delfs et al 2000;Shaham et al 2000). Recent studies have suggested a mutually antagonistic interaction between galanin and norepinephrine acting at ␣ 2 adrenergic receptors (DiazCabiale et al 2000a,b).…”

Section: The Neuropeptide Galanin Has Been Identified As a Possible Nmentioning

confidence: 99%

Modulatory Effects of Galanin in the Lateral Bed Nucleus of the Stria Terminalis on Behavioral and Neuroendocrine Responses to Acute Stress

Khoshbouei

Cecchi

Morilak

2002

Neuropsychopharmacology

View full text Add to dashboard Cite

The neuropeptide galanin has been identified as a possible neurotransmitter/neuromodulator within the central nervous system. In the present study, a potential role for galanin in the lateral bed nucleus of the stria terminalis (BSTL) in modulating behavioral and neuroendocrine responses to an acute stress was investigated. In the first experiment, acute immobilization stress induced anxietylike behavioral responses in ratsSince its discovery (Tatemoto et al. 1983), the peptide neurotransmitter galanin has been implicated in numerous autonomic and physiologic regulatory processes, including feeding (Crawley 1999), cardiovascular control (Shih et al. 1996), learning and memory (McDonald et al. 1998), and the response to stress (Holmes et al. 1995; Khoshbouei et al. 2000;Sweerts et al. 1999Sweerts et al. , 2000. Furthermore, it has been hypothesized that galanin may also be involved in disease states such as depression (Seutin et al. 1989), feeding disorders (Crawley et al. 1990(Crawley et al. , 1993, and Alzheimer's disease (Bartfai et al. 1992;Mufson et al. 1993Mufson et al. , 1998Mufson et al. , 2000.Limbic forebrain structures important for the expression of fear and anxiety, such as the central nucleus of the amygdala and the bed nucleus of the stria terminalis (BST), show a rich expression of galanin and galanin receptors (Bartfai et al. 1992; Gustafson et al. 1996; Melander et al. 1986a,b). Within the BST, there is extensive overlap between galanin-immunoreactive terminals and galanin receptors (Gray and Magnuson 1987b; . 1993b, 1997). The BST is a component of the "extended amygdala", which plays a critical role in the integration of autonomic and behavioral responses to stress (Davis and Shi 1999; Davis et al. 1997a; Herman and Cullinan 1997). The lateral BST (BSTL) in particular has been implicated in modulation of behavioral-affective responses (Cecchi et al. 2001; Davis and Shi 1999). Lesions of the BST blocked the enhancement of acoustic startle induced by i.c.v. infusion of CRH (Davis et al. 1997b). Similarly, blockade of glutamate receptors in BSTL antagonized the unconditioned potentiation of startle induced by exposure to bright light (reviewed by (Davis and Shi 1999)).In addition to playing a potential role in modulating the behavioral response to stress, the BSTL also exerts an extrahypothalamic modulatory influence on stressinduced hypothalamic-pituitary-adrenal (HPA) activation (Cecchi et al. 2001; Herman and Cullinan 1997; Herman et al. 1996). While some investigators have suggested that the BST has an inhibitory influence on HPA activation (Herman and Cullinan 1997), others have suggested a facilitatory role. A small cluster of CRF-immunoreactive neurons in ventrolateral BST project to mid-parvocellular PVN (Moga and Saper 1994). Lesions of BST attenuated the increase in plasma ACTH and corticosterone induced by reintroduction of rats into a context in which they had previously been exposed to foot shock (Gray et al. 1993), and specific lesioning of anterolateral BST cause a decrease ...

show abstract

“…Levels of methoxyhydroxyphenylglycol (MHPG) in the microdialysate were measured in each alumina supernatant (20).…”

Section: Assaysmentioning

confidence: 99%

“…In the present study, we sought to characterize age-associated changes in central and peripheral catecholaminergic activity of young and old male 344/N Fischer rats, a well characterized strain for aging studies, under basal conditions and during acute IMMO, a stressor known to activate both catecholaminergic systems and the HPA axis (20,21 …”

Section: Introductionmentioning

confidence: 99%

Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N Fischer rats.

et al. 1995

View full text Add to dashboard Cite

We investigated the effects of stress on central and peripheral sympatho-adrenal and sympatho-neural functions in healthy, intact young (3-4 mo) and aged (24 mo) male Fischer 344/N rats.Extracellular fluid (ECF) levels of the catecholamines norepinephrine (NE), dihydroxyphenylglycol (DHPG), methoxyhydroxyphenylglycol (MHPG), and dihydroxyphenylacetic acid (DOPAC) were obtained by microdialysis in the paraventricular nucleus (PVN) of the hypothalamus at baseline and during immobilization (IMMO). The baseline levels of these substances were similar in both age groups, and their concentrations increased significantly in response to IMMO. The IMMO-induced increases of NE and MHPG, however, were significantly smaller in old than in young rats.Plasma levels of the catecholamines NE, DHPG, MHPG, DOPAC, dihydroxyphenylalanine (DOPA), epinephrine (EPI), dopamine (DA), and HVA were also determined in young and old rats during IMMO. Basal levels of these substances were significantly higher in old than in young rats. The magnitude of the IMMO-induced increases in the majority of these compounds however, was significantly smaller in old than in young rats.We conclude that, at the basal state, aging in the Fischer rat is associated with normal PVN ECF, but high plasma catecholamine levels; at stress state, however, old rats have substantially lesser activation of their central and peripheral catecholaminergic systems than young rats. (J. Clin. Invest. 1995Invest. . 95:1217Invest. -1224

show abstract

Effects of Single or Repeated Immobilization on Release of Norepinephrine and Its Metabolites in the Central Nucleus of the Amygdala in Conscious Rats

Cited by 65 publications

References 28 publications

The Role of the Amygdala in Regulating the Hypothalamic-Pituitary-Adrenal Axis

The Role of the Amygdala in Regulating the Hypothalamic-Pituitary-Adrenal Axis

Modulatory Effects of Galanin in the Lateral Bed Nucleus of the Stria Terminalis on Behavioral and Neuroendocrine Responses to Acute Stress

Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N Fischer rats.

Contact Info

Product

Resources

About