Effects of stable fish oil and simvastatin on plasma lipoproteins in patients with hyperlipidemia

Liu, Meilin; Wallmon, Agneta; Wallin, Rolf; Saldeen, Tom

doi:10.1016/s0271-5317(03)00102-7

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Adherence to CV medication was reported for co-administration of coenzyme Q10 plus statins, omega-3 fatty acids plus statins, and vitamin E plus statins in five studies [38-40,43,52]. …”

Section: Resultsmentioning

confidence: 99%

“…In three short-term RCTs [38,43,52], adherence to CV drugs as judged by pill count was greater than 95% in both treatment groups.…”

Section: Resultsmentioning

confidence: 99%

“…Co-administration with statins showed no benefit of lowering low density lipoprotein-cholesterol (LDL-C) (Figure 2) [41,43,52,74,81], total cholesterol [41,43,52,74,81], or of increasing HDL-C (grade: low) (Figure 3) [41,43,52,74,75,81]. However, the effect of adding statins to omega-3 fatty acids in participants with high baseline triglyceride levels (>200 mg/mL) was beneficial in lowering post-treatment triglyceride levels [41,73] (grade: low), as opposed to participants with lower baseline levels of triglyceride for whom the results were inconclusive (grade: insufficient) [41,43,52,73,74,81].…”

Section: Resultsmentioning

confidence: 99%

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Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review

et al. 2012

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BackgroundThe objective of this systematic review was to examine the benefits, harms and pharmacokinetic interactions arising from the co-administration of commonly used dietary supplements with cardiovascular drugs. Many patients on cardiovascular drugs take dietary supplements for presumed benefits and may be at risk for adverse supplement-drug interactions.MethodsThe Allied and Complementary Medicine Database, the Cochrane Library, EMBASE, International Bibliographic Information on Dietary Supplements and MEDLINE were searched from the inception of the review to October 2011. Grey literature was also reviewed.Two reviewers independently screened records to identify studies comparing a supplement plus cardiovascular drug(s) with the drug(s) alone. Reviewers extracted data using standardized forms, assessed the study risk of bias, graded the strength of evidence and reported applicability.ResultsEvidence was obtained from 65 randomized clinical trials, 2 controlled clinical trials and 1 observational study. With only a few small studies available per supplement, evidence was insufficient for all predefined gradable clinical efficacy and harms outcomes, such as mortality and serious adverse events. One long-term pragmatic trial showed no benefit from co-administering vitamin E with aspirin on a composite cardiovascular outcome. Evidence for most intermediate outcomes was insufficient or of low strength, suggesting no effect. Incremental benefits were noted for triglyceridemia with omega-3 fatty acid added to statins; and there was an improvement in levels of high-density lipoprotein cholesterol with garlic supplementation when people also consumed nitratesConclusionsEvidence of low-strength indicates benefits of omega-3 fatty acids (plus statin, or calcium channel blockers and antiplatelets) and garlic (plus nitrates or warfarin) on triglycerides and HDL-C, respectively. Safety concerns, however, persist.

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“…Adherence to CV medication was reported for co-administration of coenzyme Q10 plus statins, omega-3 fatty acids plus statins, and vitamin E plus statins in five studies [38-40,43,52]. …”

Section: Resultsmentioning

confidence: 99%

“…In three short-term RCTs [38,43,52], adherence to CV drugs as judged by pill count was greater than 95% in both treatment groups.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review

et al. 2012

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“…It is also reported to suppress the risk of obesity, diabetes, atherosclerosis, hyperlipidemia and hypertension 22 . Fish oil in combination with a drug named Simvastatin may lower the cholesterol level 23 as shown in Graph 1. …”

Section: Fish Oilmentioning

confidence: 99%

Consuming Fish for Nutrition and Medicine Is Boon or Doom: A Review on Scientific Perspective

Banerjee¹,

Rajan²

2017

Int. J. Res. Ayurveda Pharm.

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Fish are known to be rich source of proteins, minerals and certain vitamins including low saturated fatty acids comprising of omega-3 fatty acid. These dietary sources are considered not only healthy but also nutritious diet for proper growth and development of bones and proper physiological functioning of a healthy body. The fish oil which is consumed worldwide for eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) has its own merits. These advantages are masked by the pollution and ill effects of consuming fish. It has also been reported that accumulation of toxins and other xenobiotic compounds are major concern when discussing the consumption of fish. This is scientific study which highlights both the sides of coin i.e. unbiased projection of benefits verses harmful effects. The health benefits which are discussed elaborately are equi-balanced by deleterious effects leading to the conclusion on this long-debated topic.

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“…Intake of simvastatin 10 mg daily resulted in decreased total cholesterol, LDL, and LDL/HDL ratio (P < 0.0001). Fish oil markedly potentiated the tri acylglycerol lowering effect of simvastatin, whereas simvastatin markedly potentiated the cholesterol reducing effect of fish oil [139]. Villalobos et al [140] suggest that the combined use of statins and u 3 polyunsaturated fatty acids improves cardio vascular protection, reduces the cardiovascular disease related mortality rate through reduction of cholesterol, inflammation, thrombogenesis, and normalizes endothelial function.…”

Section: Interaction Of Natural Products With Statin Drugsmentioning

confidence: 99%

Cholesterol overload impairing cerebellar function: The promise of natural products

El‐Sayyad

2015

Nutrition

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Effects of stable fish oil and simvastatin on plasma lipoproteins in patients with hyperlipidemia

Cited by 6 publications

References 28 publications

Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review

Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review

Consuming Fish for Nutrition and Medicine Is Boon or Doom: A Review on Scientific Perspective

Cholesterol overload impairing cerebellar function: The promise of natural products

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