Effects of Stachys tibetica essential oil in anxiety

Kumar, Dinesh; Bhat, Zulfiqar Ali; Kumar, Vadlapudi; Khan, Nisar Ahmad; Chashoo, I. A.; Zargar, Mohammed Iqbal; Shah, M. Y.

doi:10.1016/j.eujim.2012.01.005

Cited by 30 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of head dips was taken into account in this behavioral paradigm. Head dips indicate exploratory behavior of mice, which is assumed as anxiolytic behavior of animal (Boissier and Simon 1964;Crawley 1985;Kumar et al 2012;Yadav et al 2008). …”

Section: Hole-board Test (Hbt)mentioning

confidence: 99%

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

2017

View full text Add to dashboard Cite

Depression and anxiety are the most crippling neuropsychiatric disorders of this modern era. These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, Garcinia indica, commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively. Garcinia indica fruit rind given to mice with food for consecutive 14 days at 0.5, 1, and 2% w/w significantly (p \ 0.05) reduced despair behavior in forced swim test, immobility duration in tail suspension test, and also switched the hypothermia (reserpine induced) to normal temperature significantly (p \ 0.05). Garcinia indica significantly (p \ 0.05) raised the time elapsed and count of entries in open arms of elevated plus maze, enhanced incidence of head dipping in holes of hole board along with duration of expending time in lit compartment of light dark model, exhibiting its anti-anxiety effect. Garcinia indica significantly reduced monoamine oxidase and malondialdehyde levels providing support to neuroprotective potential of fruit rind. The mechanistic study showed the participation of G. indica at a 1 -adrenoceptor and D 2 -dopamine receptor, by attenuating prazosin and sulpirideinduced increase in immobility duration. Garcinia indica fruit rind showed a significant antidepressant and anxiolytic effect while no effect on locomotor activity, i.e., no psycho-stimulation.

show abstract

Section: Hole-board Test (Hbt)mentioning

confidence: 99%

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

2017

View full text Add to dashboard Cite

show abstract

“…Additionally, Hypericum perforatum commonly known as St. Johns Wort; is the most well-known herbal product available over the counter [10]. Previous studies have shown that a number of plants from this family, including Salvia officinalis, Salvia elegans, Salvia reuterana, and Scutellaria baicalensis have shown anti-anxiety activity [10,43]. Stachystibetica is distributed in the tropical and subtropical regions of the world, including in Tibet, China, India, etc.…”

Section: Relevant Plants Worldwidementioning

confidence: 99%

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

Lima¹,

Pontes²,

Pinho³

et al. 2015

Int Arch Med

View full text Add to dashboard Cite

Background: Popular medicine has been used to treat some diseases including mental disorders since the ancient times. The development of this powerful tool can bring to the actual world some benefits to improve the way of taking care of mental illnesses. Objective: To show relevant studies about biopharmaceuticals and to infer the equivalence of using biopharmaceuticals, regarding to efficacy and safety as the chemical-type drugs in the treatment for mental disorders, assessing whether there are biomolecules that might work as biopharmaceuticals to treat, cure or mitigate different mental disorders. Methods: A systematic review from 01.01.2004 to 25.28.2014 was performed on the databases PubMed, Scopus and Science Direct. The search was performed with the descriptor ''mental disorders'' and with the keywords ''biopharmaceuticals'' and ''biomolecules''. The information pertinent to the study was selected, categorized and analyzed. Of the 339 articles found, 20 met the eligibility criteria. Results: Eastern culture, followed by Amazonian region concentrated most of the species related with popular treatment of mental disorders. Several species were revealed to act upon receptors or neurotransmitters in the Central Nervous System (CNS), which, sometimes, is a similar mechanism of action of a lot of well-known synthetic drugs on the market. It was also highlighted the use of the genetic knowled

show abstract

“…In a different report, the major components in Stachys tibetica essential oil were aciphyllene (66.415%), fenchyl alcohol (8.897%), α-pinene (8.188%) and caryophyllene oxide [25] . In a study, lavandulifolioside B and 5-O-β-allopyranosyloxy-aucubin in S. lavandulifolia Vahl were identified comprehensively by extensive 1D and 2D NMR analyses [26] .…”

Section: Introductionmentioning

confidence: 96%

Phytochemical composition of the essential oil of different populations of Stachys lavandulifolia Vahl

Pirbalouti

Mohammadi

2013

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Effects of Stachys tibetica essential oil in anxiety

Cited by 30 publications

References 30 publications

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

Phytochemical composition of the essential oil of different populations of Stachys lavandulifolia Vahl

Contact Info

Product

Resources

About