Effects of surface tension and viscosity on the forming and transferring process of microscale droplets

Chen, Shulei; Liu, Kun; Liu, Cunbin; Wang, Dongyang; Ba, Dechun; Xie, Yonghong; Du, Guangyu; Ba, Yi; Lin, Qiao

doi:10.1016/j.apsusc.2016.01.205

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…A series of index parameters are also required to be taken into consideration, including the capture efficiency and loading time of the cell, the pressure and velocity distribution of the fluid, the deformation, and the equivalent stress of the cell. Based on the hydrodynamic cell capture method [ 23 ] and our previous study [ 24 , 25 ], three types of microstructures were designed, including seamless, single-slit, and double-slit traps, as shown in Figure 1 .…”

Section: Problem Formationmentioning

confidence: 99%

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells

Chen

Wang

et al. 2018

Micromachines

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The application of microfluidic technology to manipulate cells or biological particles is becoming one of the rapidly growing areas, and various microarray trapping devices have recently been designed for high throughput single-cell analysis and manipulation. In this paper, we design a double-slit microfluidic chip for hydrodynamic cell trapping at the single-cell level, which maintains a high capture ability. The geometric effects on flow behaviour are investigated in detail for optimizing chip architecture, including the flow velocity, the fluid pressure, and the equivalent stress of cells. Based on the geometrical parameters optimized, the double-slit chip enhances the capture of HeLa cells and the drug experiment verifies the feasibility of the drug delivery.

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Section: Problem Formationmentioning

confidence: 99%

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells

Chen

Wang

et al. 2018

Micromachines

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“…The Young-Laplace equation was used to obtain the contact angle of silicon oil-water on PDMS. The surface tension of silicon oil-water system was taken as 42.6 mN/m [28], the air-silicon oil system as 20.8 mN/m (provided by the silicon oil manufacturer Dow Corning), the air-water system as 72.1 mN/m and the contact angle for air-silicon oil system was taken as 15 • [29], the air-water system as 98 • [29]. The contact angle of oil-water system in these simulations was obtained as 135 • [29].…”

Section: Numerical Simulationmentioning

confidence: 99%

“…The surface tension of silicon oil-water system was taken as 42.6 mN/m [28], the air-silicon oil system as 20.8 mN/m (provided by the silicon oil manufacturer Dow Corning), the air-water system as 72.1 mN/m and the contact angle for air-silicon oil system was taken as 15 • [29], the air-water system as 98 • [29]. The contact angle of oil-water system in these simulations was obtained as 135 • [29]. The contact angle of oil-water on PCTE is not necessary to be calculated, because the capillary force between microdroplet and culture solution would impact the shape of microdroplet apparently.…”

Section: Numerical Simulationmentioning

confidence: 99%

“…Numerical simulations were performed in the boundary condition with Q water ≤ Q oil ≤ 60 µL/min or U water ≤ U oil ≤ 0.1 m/s according to our former experiments [29]. The interface tension between the two phases was taken as 0.06 N/m, because the microdroplet fully fills the microchannel so as to cling to microporous membrane to prompt convective diffusion.…”

Section: Numerical Simulationmentioning

confidence: 99%

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Effects of Pulse Interval and Dosing Flux on Cells Varying the Relative Velocity of Micro Droplets and Culture Solution

et al. 2018

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Microdroplet dosing to cell on a chip could meet the demand of narrow diffusion distance, controllable pulse dosing and less impact to cells. In this work, we studied the diffusion process of microdroplet cell pulse dosing in the three-layer sandwich structure of PDMS (polydimethylsiloxane)/PCTE (polycarbonate) microporous membrane/PDMS chip. The mathematical model is established to solve the diffusion process and the process of rhodamine transfer to micro-traps is simulated. The rhodamine mass fraction distribution, pressure field and velocity field around the microdroplet and cell surfaces are analyzed for further study of interdiffusion and convective diffusion effect. The cell pulse dosing time and drug delivery efficiency could be controlled by adjusting microdroplet and culture solution velocity without impairing cells at micro-traps. Furthermore, the accuracy and controllability of the cell dosing pulse time and maximum drug mass fraction on cell surfaces are achieved and the drug effect on cells could be analyzed more precisely especially for neuron cell dosing.

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“…Extensive study of the corrosion mechanism in oil-water two-phase flow has related the occurrence of water wetting to the formation of corrosion. However, many factors can affect the process of water wetting, including the water cut, pipe diameter, fluid velocity, pipe angle of inclination, oil properties, surface tension, inhibitors, roughness, temperature, and so on (Cai & Nesic, 2004;Chen et al, 2016;Li, 2009;Menad et al, 2019;Sun et al, 2019;Tang, Richter, & Nesic, 2008;Zhang, Lan, & Lin, 2019). Pouraria, Seo, and Paik (2016a) investigated the influence of different velocities and water cuts in oil-water two-phase flow on water wetting using computational fluid dynamics (CFD).…”

Section: Introductionmentioning

confidence: 99%

Numerical study of the hydrodynamic parameters influencing internal corrosion in pipelines for different elbow flow configurations

Liu

Gong

Zhang

et al. 2019

Engineering Applications of Computational Fluid Mechanics

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Oil-water two-phase flow is common in the ocean engineering, petroleum, and chemical industries, among others. In the transportation process, the elbow system-as a paramount component-usually suffers from internal corrosion. In order to investigate the corrosion-prone characteristics of elbow systems, the volume of fluid (VOF) method and the renormalization group (RNG) kmodel were used to study the oil-water flow in three different elbow configurations. The results indicate that the maximum wall shear stress and mass transfer coefficient are located at the intrados of the elbow for all flow configurations. Nevertheless, for horizontal-upward and horizontal-horizontal elbow flows, water does not come into direct contact with the intrados of the elbow, meaning it is much less susceptible to corrosion. Thus, a multiparameter model which also takes into account the water-volume fraction is necessary for characterizing the corrosion process. When this was combined with an analysis of the water wetting process, the horizontal-downward elbow flow was found to exhibit the largest corrosion risk among the three configurations examined, the horizontal-upward elbow flow was the least susceptible and the horizontal-horizontal elbow flow was in the middle.

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Effects of surface tension and viscosity on the forming and transferring process of microscale droplets

Cited by 14 publications

References 19 publications

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells

Effects of Pulse Interval and Dosing Flux on Cells Varying the Relative Velocity of Micro Droplets and Culture Solution

Numerical study of the hydrodynamic parameters influencing internal corrosion in pipelines for different elbow flow configurations

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