Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster

Miquel, Jaime; Lundgren, P.; Bensch, Klaus G.; Atlan, Henri

doi:10.1016/0047-6374(76)90034-8

Cited by 318 publications

(184 citation statements)

References 24 publications

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“…They are shorter than the lifespans of flies kept under 20°C (Schnebel & Grossfield, 1983; Table S1). The more rapid aging in flies under higher temperatures was also observed previously (Miquel, Lundgren, Bensch & Atlan, 1976). Within each species, the female flies were generally larger in size than the male flies (Table S1).…”

Section: Resultssupporting

confidence: 86%

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Avanesov

Porter

et al. 2018

Aging Cell

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SummaryLifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life‐history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that longer‐lived flies upregulate fatty acid metabolism, downregulate neuronal system development and activin signaling, and alter dynamics of RNA splicing. Interestingly, these gene expression patterns resembled those of flies under dietary restriction and several other lifespan‐extending interventions, although on the individual gene level, there was no significant overlap with genes previously reported to have lifespan‐extension effects. We experimentally tested the lifespan regulation potential of several candidate genes and found no consistent effects, suggesting that individual genes generally do not explain the observed longevity patterns. Instead, it appears that lifespan regulation across species is modulated by complex relationships at the system level represented by global gene expression.

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Section: Resultssupporting

confidence: 86%

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Avanesov

Porter

et al. 2018

Aging Cell

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“…The studies reported here, in conjunction with previous work from our group (Goddeeris et al 2003;Gargano et al 2005) and others (Miquel et al 1976;Arking and Wells 1990;Chavous et al 2001;Mockett et al 2001;Kang et al 2002;Ruan et al 2002;Morrow et al 2004;Simon et al 2006), indicate that locomotor senescence might be mechanistically connected to life span in Drosophila; i.e. long-lived flies tend to have better locomotor function across age.…”

Section: Discussionsupporting

confidence: 77%

“…Negative geotaxis (startleinduced vertical movement) is a frequently used index of locomotor behavior in flies (Miquel et al 1976;Arking and Wells 1990;Chavous et al 2001;Mockett et al 2001;Kang et al 2002;Ruan et al 2002;Goddeeris et al 2003;Morrow et al 2004;Gargano et al 2005;Simon et al 2006).Despite being commonly assessed, it was previously unclear whether negative geotaxis is principally a climbing behavior or a combination of climbing and other behaviors such as jumping and flying. Additionally, it was previously unclear whether age-related impairment in negative geotaxis is due to a decreased speed of vertical movement, an increased latency to initiate vertical movement, or other age-related behavioral changes.…”

Section: Introductionmentioning

confidence: 99%

Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed

Rhodenizer

Martin

Bhandari

et al. 2008

Experimental Gerontology

117

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Age-related locomotor impairment in humans is important clinically because it is associated with several co-morbidities and increased risk of death. One of the hallmarks of age-related locomotor impairment in humans is a decrease in walking speed with age. Genetically tractable model organisms such as Drosophila are essential for delineating mechanisms underlying age-related locomotor impairment and age-related decreases in locomotor speed. Negative geotaxis, the ability of flies to move vertically when startled, is a common measure of locomotor behavior that declines with age in Drosophila. Toward further developing Drosophila as a model for age-related locomotor impairment, we investigated whether negative geotaxis reflects climbing or a combination of climbing and other behaviors such as flying and jumping. Additionally, we investigated whether locomotor speed in negative geotaxis assays declines with age in flies as found for walking speed in humans. We find that the vast majority of flies climb during negative geotaxis assays and that removal of hind legs, but not wings, impairs the behavior. We also find that climbing speed decreases with age in four wild type genetic backgrounds, in flies housed at different temperatures, and in control and long-lived flies harboring a mutation in OR83b. The decreases in climbing speed correlate with the age-related impairments in the distance climbed. These studies establish negative geotaxis in Drosophila as a climbing behavior that declines with age due to a decrease in climbing speed. Agerelated decreases in locomotor speed are common attributes of locomotor senescence in flies and humans.

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“…However, once the mortality increase is detected, it proceeds at roughly the same rate in calorie restricted and control flies [19,24]. This differs from the effects of lowered temperature, which increases lifespan in Drosophila, but also reduces the slope of the mortality trajectory [19,20]. In contrast, mice with a reduced CBT show a reduced 'frailty' parameter in the Gompertz, similar to what is observed during CR.…”

Section: Thermodynamic Effects and Specific Pathwaysmentioning

confidence: 82%

“…In poikilotherms the effects of CR and temperature on longevity can be distinguished by the slopes of the mortality curves [19][20][21][22][23]. In Drosophila, chronic CR results in a delay in the onset of a detectable aging-related increase in mortality.…”

Section: Thermodynamic Effects and Specific Pathwaysmentioning

confidence: 99%

Considerations on Temperature, Longevity and Aging

Conti

2008

Cell. Mol. Life Sci.

105

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Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster

Cited by 318 publications

References 24 publications

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed

Considerations on Temperature, Longevity and Aging

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