Effects of testosterone and vitamin E on the antioxidant system in rabbit testis

Abstract

The aim of the study was to investigate the effects of testosterone propionate and vitamin E on the antioxidant system in the testis. Thirty-two male New Zealand White rabbits were randomly divided into four groups. The first group was used as control. The second group was injected with testosterone propionate, the third group vitamin E and the fourth group vitamin E and testosterone propionate combination. All treatments were carried out during 6 weeks and oxidative parameters were evaluated in homogenized testicular tissue. The levels of vitamin E and the activity of glutathione peroxidase were lower (P < 0.05) in the testosterone group than in controls. However, vitamin C and malondialdehyde levels were higher (P < 0.05) in this group than in controls. The levels of reduced glutathione, beta-carotene, vitamin C and E increased, but malondialdehyde levels decreased in the vitamin E group, when compared with controls (P < 0.05). Vitamin E and beta-carotene levels were significantly higher (P < 0.05) in the combination group than in testosterone group. However, MDA levels were lower (P < 0.05) in combination group than in the testosterone group. In conclusion, administration of testosterone propionate led to a significant elevation of oxidative stress. Vitamin E is quite an effective antioxidant which protects rabbit testis against lipid peroxidation, and, testosterone-induced lipid peroxidation could be improved by additional vitamin E treatment.

Testosterone Induces Vascular Smooth Muscle Cell Migration by NADPH Oxidase and c-Src–Dependent Pathways

“…In addition, we show a key role of c-Src in both genomic and nongenomic effects of testosterone in VSMCs. Our data corroborate previous studies showing that testosterone induces oxidative stress in rabbit and rat prostate 34,35 and is related to augmentation of blood pressure levels in different animal models of hypertension.…”

Sex-specific effects of prenatal testosterone on nestling plasma antioxidant capacity in the zebra finch

“…If egg hormone treatment were to result in consistently higher nestling blood levels of testosterone or related steroids this would probably affect plasma total antioxidant capacity. It has been shown that high levels of circulating testosterone impair antioxidant enzymes in rat and rabbit testicular tissues (Chainy et al, 1997;Aydilek et al, 2004) [but see Peltola et al (Peltola et al, 1996)]. Moreover, high testosterone blood levels have recently been shown also to negatively influence red blood cell resistance to a free radical attack in adult zebra finch males (Alonso-Alvarez et al, 2007b).…”

Evaluation of the gametotoxic effect of nandrolone decanoate on the gametogenic function of male rabbit

“…A number of studies have drawn the attention on the adverse reactions produced by some hormonal chemicals, with direct effects on the spermatogenetic function (4). Such results were reported after the administration of substances such hexestrol diacetate (5), dienestrol (6), nortestosterone decanoate (7) and estradiol benzoate (8). The studies were conducted on pubescent males belonging to several species of mammals: rats (3), mice (7), Guinea pigs (9), and rabbits (5).…”