Effects of the herbal medicine composition “Saiko-ka-ryukotsu-borei-To” on the function of endothelial progenitor cells in hypertensive rats

Iijima, Hiroshi; Daikonya, Akihiro; Takamatsu, Satoshi; Kanno, Ai; Magariyama, Kayoko; Yoshikawa, Kunio; Takamiya, Tomoko; Ueda, Yukiko; Yakubo, Shuji; Matsumoto, Tarô; Ueno, Takayoshi; Yamori, Yukio; Fukuda, Noboru; Kitanaka, Susumu

doi:10.1016/j.phymed.2012.10.014

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Chinese herbal medicine is a mixture of many herbs following the theory of traditional Chinese medicine (11,12). Among these herbs, the main drugs that contain Scutellaria root are Shosaikoto (Xiao-Chai-Hu-Tang) (13), Daisaikoto (Da-Chai-Hu-Tang) (14), Saireito (Chai-Ling-Tang) (15), Saikokeishito (Chai-Hu-Gui-Zhi-Tang) (16), and Saikokaryukotsuboreito (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) (17). The medicinal effects of these medicines improve gastrointestinal, liver and breathing responses, targets immune function, and relieves inflammation (18).…”

Section: Introductionmentioning

confidence: 99%

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

Ohkoshi

Umemura

2016

International Journal of Oncology

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CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baicalein did not enhance apoptosis and upregulated CD44 in head and neck squamous cell carcinoma. Furthermore, baicalein induced phosphorylation of CHK1, as a marker of DNA damage response to S-to-G2/M phase arrest. Our results clearly demonstrated that baicalein enhanced expression of CD44 and accordingly enhanced the DNA damage response. These data suggest that induction of CD44 inhibited cancer cell induction of apoptosis by increasing the DNA damage response. Together, our findings suggest that CD44 expression in head and neck squamous cell carcinoma plays a role in enhancing the DNA damage response.

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Section: Introductionmentioning

confidence: 99%

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

Ohkoshi

Umemura

2016

International Journal of Oncology

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“…Among several kampo formulae, we chose SRB and HJG because both have therapeutic potential for vascular system‐related symptoms, in that SRB has been shown to protected endothelial progenitor cells in spontaneously hypertensive rats , and HJG was introduced because of its effectiveness on hypertension as well as on renal blood flow .…”

Section: Discussionmentioning

confidence: 99%

“…This formula is recommended for those who have sufficient energy but who have symptoms such as arteriosclerosis, hypertension, anxiety, and insomnia . SRB protects endothelial progenitor cells from oxidative stress in spontaneously hypertensive rats .…”

Section: Introductionmentioning

confidence: 99%

Saikokaryukotsuboreito during pregnancy protects rat neonates from maternal cannibalism and death in a neurolathyrism experimental model

Kusama-Eguchi

Kawaguchi

Yakubo

et al. 2016

Traditional & Kampo Medicine

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Aim: Stress during the perinatal period may result in failure to thrive in the newborn. A possible preventive effect of two kampo formulae, saikokaryukotsuboreito (SRB) and hachimijiogan (HJG) on the incidence of hind-leg paraparesis and mortality in newborns, including that due to maternal cannibalism, were examined in neurotoxin-treated rats. Methods: Female Wistar/ST rats treated with SRB or HJG during pregnancy and the lactation period were separated from their pups for 6 h daily and then reunited. The pups were treated daily with a neurotoxin, L-β-N-oxalyl-α,β-diaminopropionic acid (L-β-ODAP), to cause neurolathyrism-like symptoms, a motor defect leading to hind-leg paraparesis. Results: Although SRB and HJG treatment in mother rats did not affect the incidence of motor defect (paraparesis) in the pups, pup mortality was greatly and significantly decreased during the treatment period in the SRB group but not in the HJG group. Conclusion: SRB treatment in mother rats is effective in decreasing pup mortality mainly due to cannibalism, thus suggesting its potential for anxiety disorder during the perinatal period in humans.

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“…Traditional Chinese medicine (TCM) has characteristics of multi-compound, multi-target, and multi-channel aspects [ 8 ]. Some Chinese medicine has significant anti-inflammatory, antioxidant, and other effects [ [9] , [10] , [11] ]. In addition, a unique feature of TCM is that it has unexpected therapeutic effects on complex diseases: there exists an early understanding of hypertension [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Zhijing powder manages blood pressure by regulating PI3K/AKT signal pathway in hypertensive rats

Wang

Zhang

et al. 2023

Heliyon

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Effects of the herbal medicine composition “Saiko-ka-ryukotsu-borei-To” on the function of endothelial progenitor cells in hypertensive rats

Cited by 6 publications

References 29 publications

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

Saikokaryukotsuboreito during pregnancy protects rat neonates from maternal cannibalism and death in a neurolathyrism experimental model

Zhijing powder manages blood pressure by regulating PI3K/AKT signal pathway in hypertensive rats

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