Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function

Kim, Hyun Jung; Park, Sun Young; Kim, Dae Geon; Park, Sohae; Lee, Heeseob; Hwang, Dae Youn; Jung, Myeong Ho; Ha, Ki‐Tae; Kim, Byung Joo

doi:10.1016/j.jep.2016.03.012

Cited by 24 publications

(19 citation statements)

References 57 publications

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“…PF (1 g/kg), which has been shown to have prokinetic activity in the GI tract[17,18], significantly accelerated the ITR [79.4% ± 2.3% ( P < 0.01)], similar to the Lizhong Tang extract, which dose-dependently increased the ITR (%) [ITR values at 0.01, 0.1 and 1 g/kg were 56.1% ± 2.1%, 65.2% ± 1.8% ( P < 0.01) and 83.8% ± 1.9% ( P < 0.01), respectively; Figure 2]. Loperamide decreased the ITR (%), which is consistent with previous reports[19], and the Lizhong Tang extract inhibited this loperamide-induced decrease in ITR [ITR value for loperamide was 56.1% ± 2.1%; and ITR value for loperamide with the Lizhong Tang extract was 65.2% ± 1.8% ( P < 0.01); Figure 2].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Lizhong Tang on gastrointestinal motility in mice

Lee

Park

et al. 2016

WJG

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AIMTo investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.METHODSThe in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).RESULTSIn normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.CONCLUSIONThese results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

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Section: Resultsmentioning

confidence: 99%

“…In addition, an aqueous extract of the dried immature fruit of Poncirus trifoliate Raf. (PF) was prepared as previously described[17,18] and its prokinetic activities were compared with the Lizhong Tang extract. PF is one of the most popular traditional folk medicines used in South Korea and is obtained from Rutaceae fruits.…”

Section: Methodsmentioning

confidence: 99%

Effects of Lizhong Tang on gastrointestinal motility in mice

Lee

Park

et al. 2016

WJG

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“…Recent studies on herbal medicines, such as Lizhong Tang and Dangkwisoo-san, reported that these modify the gastrointestinal motility or pacemaker activities of ICCs [30,31]. In addition, some herbal extracts of the roots of ginger and Liriope Platyphylla Wang et Tang have been reported to mediate the contraction of the ileal smooth muscle in rats [32,33]. Reportedly, naringenin, a citrus peel component, inhibits the pacemaking activity in ICCs [34].…”

Section: Discussionmentioning

confidence: 99%

Differential Inhibition of the Rhythm and Amplitude of Acetylcholine-Dependent Contraction in the Murine Jejunum and Ileum <i>In Vitro</i> by Thiamin and Quinine

Yamashita¹,

Shimamoto²,

Morita³

et al. 2018

JFNS

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Previously, the effects of several bitter substances have been investigated in the contraction of the murine jejunum and ileum, reporting that these independently suppress the rhythm generation of the interstitial cells of Cajal. Recently, it was reported that thiamin, which binds to a bitter taste receptor, modifies the early phase of the ileum contraction, whereas the physiological effects on the rhythm and amplitude of jejunum and ileum contractions remain unclear. In this study, it was investigated the physiological effects of thiamin and quinine on the in vitro contraction of the murine jejunum and ileum using mice for all experiments. the periodic contraction of the jejunum was observed before the administration of acetylcholine (Ach) and other substances, and the tonic amplitudes induced by the substances. These bitter substances variably affect the Achinduced rhythmic contraction of the jejunum and ileum in vitro. In addition, quinine hydrochloride (Qui) and thiamin hydrochloride (Thi) variably affect the Ach-induced rhythmic contraction of the jejunum and ileum in vitro. Both Qui and Thi markedly increase the rhythmic contraction in the jejunum. Although Thi does not change the rhythmic contraction in the ileum, it gradually reduces the amplitude in the jejunum. Conversely, Qui gradually reduces the amplitude and almost inhibits the contraction in the jejunum. Furthermore, an antagonist of the adrenalin-beta3 receptor, SR59230A, enhances the Quiinduced inhibition of the contraction in the jejunum.

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“…ICCs act as pacemaker cells in GI motility function [15-17, 37, 45]. Therefore, they play a role in the generation and propagation of electrical properties in smooth muscles [15, 46].…”

Section: Discussionmentioning

confidence: 99%

Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M2 and M3 Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal

Kim¹,

Han

Kim³

et al. 2017

Cell Physiol Biochem

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Background: Magnolia officinalis Rehder and EH Wilson (M. officinalis) are traditional Chinese medicines widely used for gastrointestinal (GI) tract motility disorder in Asian countries. We investigated the effects of an ethanol extract of M. officinalis (MOE) on the pacemaker potentials of cultured interstitial cells of Cajal (ICCs) in vitro and its effects on GI motor functions in vivo. Methods: We isolated ICCs from small intestines, and the whole-cell patch-clamp configuration was used to record the pacemaker potentials in cultured ICCs in vitro. Both gastric emptying (GE) and intestinal transit rates (ITRs) were investigated in normal and GI motility dysfunction (GMD) mice models in vivo. Results: MOE depolarized ICC pacemaker potentials dose-dependently. Pretreatment with methoctramine (a muscarinic M₂ receptor antagonist) and 4-DAMP (a muscarinic M₃ receptor antagonist) inhibited the effects of MOE on the pacemaker potential relative to treatment with MOE alone. In addition, MOE depolarized pacemaker potentials after pretreatment with Y25130 (a 5-HT₃ receptor antagonist), GR113808 (a 5-HT₄ receptor antagonist) or SB269970 (a 5-HT₇ receptor antagonist). However, pretreatment with RS39604 (a 5-HT₄ receptor antagonist) blocked MOE-induced pacemaker potential depolarizations. Intracellular GDPβS inhibited MOE-induced pacemaker potential depolarization, as did pretreatment with Ca²⁺ free solution or thapsigargin. In normal mice, the GE and ITR values were significantly and dose-dependently increased by MOE. In loperamide-and cisplatin-induced GE delay models, MOE administration reversed the GE deficits. The ITRs of the GMD mice were significantly reduced relative to those of normal mice, which were significantly and dose-dependently reversed by MOE. Conclusion: These results suggest that MOE dose-dependently depolarizes ICCs pacemaker potentials through M₂ and M₃ receptors via internal and external Ca²⁺ regulation through G protein pathways in vitro. Moreover, MOE increased GE and ITRs in vivo in normal and GMD mouse models. Taken together, the results of this study show that MOE have the potential for development as a gastroprokinetic agent in GI motility function.

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Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function

Cited by 24 publications

References 57 publications

Effects of Lizhong Tang on gastrointestinal motility in mice

Effects of Lizhong Tang on gastrointestinal motility in mice

Differential Inhibition of the Rhythm and Amplitude of Acetylcholine-Dependent Contraction in the Murine Jejunum and Ileum <i>In Vitro</i> by Thiamin and Quinine

Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M2 and M3 Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal

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Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function

Cited by 24 publications

References 57 publications

Effects of Lizhong Tang on gastrointestinal motility in mice

Effects of Lizhong Tang on gastrointestinal motility in mice

Differential Inhibition of the Rhythm and Amplitude of Acetylcholine-Dependent Contraction in the Murine Jejunum and Ileum &lt;i&gt;In Vitro&lt;/i&gt; by Thiamin and Quinine

Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M2 and M3 Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal

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Differential Inhibition of the Rhythm and Amplitude of Acetylcholine-Dependent Contraction in the Murine Jejunum and Ileum <i>In Vitro</i> by Thiamin and Quinine