Effects of the stem barks aqueous extract of Anthocleista schweinfurthii Gilg (Loganiaceae) on acute and chronic gastric ulcers rats models

Mezui, Christophe; Longo, Flavia; Paul, Tan; Nkenfou, Celine; Fokou, Ntsayo; Hamani, Salou

doi:10.5897/jmpr2015.5762

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…"In general, changes in body weight of treated animals, as well as the vital organs (liver, kidneys, lungs, adrenal glands, testicles, ovaries, spleen, stomach and heart), are indicators of toxicity" [20,24].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the fact that previous acute toxicity studies conducted on Ficus thonningii(Blume) by Pougoue et al [18] and Stanley et al [20] recorded no deaths at the dose of 2000 mg/kg and above, afixed-dose of 2000 mg/kg was applied. We prepared a 100mg/mL concentrated solution.…”

Section: Preparation Of the Plant Extract Dosesmentioning

confidence: 99%

“…When the test substance was administered by gavage, this was done in a single dose to the animals using astomach tube or a suitable intubation cannula. The volume did not exceed 1 mL/100g body weight as demanded by the OECD guidelines [19,20].…”

Section: Preparation Of Animals and Administration Of Dosesmentioning

confidence: 99%

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Preclinical In vivo Acute Toxicity Testing of Hyrdoethanolic Extracts of Ficus thonningii Blume (Moraceae) on Wistar Rat Models

Fokunang

Ara

Ambassa

et al. 2023

JOCAMR

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Ficus thonningii (Blume) is a medicinal plant whose biological activity has been demonstrated in the management of peptic ulcers. Unfortunately, little scientific data exists on its toxicity. This is why we studied the acute and subacute oral toxicity profile of the hydro-ethanolic extract of the bark of F. thonningii and the systemic exposure of the bioactive components of the plant.Acute toxicity was assessed by administering a single dose of 2000 mg/kg to 5-week-old rats and observed for 14 days. The subacute toxicity study was performed in 6-week-old rats. Animals were orally treated with a daily dose of 125 mg/kg, 250 mg/kg, 500 mg/kg extract for 28 days. A satellite group of animals received 500 mg/kg per day for 28 days and after discontinuation of treatment they were observed for 14 days. Hematological and blood biochemical parameters, as well as kidney and liver histology, were recorded at the end of each experiment. For acute treatment, administration of a dose of 2000 mg/kg did not induce any critical behavioral changes or deaths. Following subacute dosing, biochemical analysis revealed a slight elevation of liver parameters in the 500mg/kg hydroethanolic extract, while no significant increase was observed for kidney parameters. This study showed that daily administration of Ficus thonningii (Blume) for 28 days resulted in the potential to reverse impairment of liver function.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of the Plant Extract Dosesmentioning

confidence: 99%

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Preclinical In vivo Acute Toxicity Testing of Hyrdoethanolic Extracts of Ficus thonningii Blume (Moraceae) on Wistar Rat Models

Fokunang

Ara

Ambassa

et al. 2023

JOCAMR

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Magnesium hydroxide nanoneedles derived fromAnthocleista schweinfurthiiGilg (Loganiaceae) support mesenchymal stromal cell proliferation and wound healing

Eya’ane Meva,

Pereira,

Ngnihamye

et al. 2024

Preprint

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Multiple metallic nanoparticles are able to promote cellular and tissue health, but these nanoparticles can be difficult to synthesize and can also cause unintended side-effects. Here, we study the effects on wounds healing and bone reparation of Mg(OH)2 from Anthocleista schweinfurthii Gilg (Loganiaceae) leaves (AS), which are local to the Africa region and have been used in traditional medicine to treat injuries. Mg(OH)2 nanoneedles were synthesized from aqueous extracts of Anthocleista schweinfurthii Gilg (Loganiaceae) leaves (AS) and magnesium nitrate. The quick polydispersing and crystallized Mg(OH)2-metal interface was found to be covered in plant secondary metabolites. We call this compound Mg(OH)2-AS. Using an acute dermal toxicity experiment on animal model, we determined that Mg(OH)2-AS is safe for topical application. In vitro experiments suggest that Mg(OH)2-AS has anti-inflammatory potential, and in vivo wound healing assays in Wistar rats indicate that Mg(OH)2-AS can enhance wound healing. To investigate Mg(OH)2-AS effects on the cellular level, we used bone marrow mesenchymal stromal cells (BM-MSCs). In contrast to pure Mg(OH)2 or AS, cell viability and proliferation were not impaired by Mg(OH)2-AS. Cell morphology remained unchanged upon media supplementation with Mg(OH)2-AS. Preliminary results further indicate enhanced osteogenic differentiation of BM-MSCs in media supplied with ascorbic acid, beta-glycerophosphate and dexamethasone and addition of Mg(OH)2-AS. These findings motivate further research towards the inclusion of the material in implants for bone fracture healing.

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Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Khémiri

Bitri

2019

Oxidative Medicine and Cellular Longevity

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Gastric ulcer is a painful lesion of the gastric mucosa which can be disabling, or even more very serious in the case of a perforation of the stomach and internal hemorrhage. Traditional pharmacopeias have shown the efficacy of various plant extracts in the treatment of this pathology. Some extracts from Opuntia ficus indica (OFI) have been proven to have medicinal therapeutic benefits. The aim of this study was to investigate the preventive and curative effects of OFI seed oil extracted by cold pressing on an ethanol-induced gastric ulcer model in rats. Gastroprotective activities of the oil were assessed as pretreatments prior to ethanol gavage of Wistar rats compared to reference drugs. Two oil dose effects were tested. Ulcer and gastric parameters were measured (ulcerated areas (mm2), % of ulcer inhibition, gastric juice volume and pH, and mucus weight). Macroscopical and microscopical assessments of the stomachs as well as gastric biopsy histological studies were carried out. OFI oil exhibited a high efficiency in the protection of the cytoarchitecture and function of the gastric mucosa against the severe damages provoked by ethanol intake. Ulcerated areas were very significantly reduced and the % of ulcer inhibition was the highest under OFI oil pretreatment. Mucus production was stimulated, gastric juice volume was reduced, and its pH was increased. Histopathological examination of H&E-stained biopsies collected from gastric mucosae from the different experimental groups confirmed the gastroprotective efficacy of OFI oil against ethanol-induced symptoms such as inflammation and damages like bleeding, erosions, lesions, necrosis, and ulcers. Furthermore, OFI oil treatment speeded-up the reduction of the surface of ethanol-induced ulcerated areas in a dose-dependent manner, leading to a time gain in the healing process. The healing rate reached 91% on day 2 and 99% on day 3, and a complete heal was attained at the fourth day under OFI oil treatment, while ulcer areas were still partially unhealed in all the other groups. The therapeutic effects of OFI oil against gastric ulcer could be mediated by its varied bioactive compounds that we have demonstrated in the analytical study. They could act synergistically or in a delayed manner to optimize the healing process through protective antioxidant properties, as well as an antagonism against histamine H2-receptors, a stimulation of the signaling pathways necessary for mucus and bicarbonate production, and reduction of inflammatory processes in the gastric mucosa. Additionally, OFI oil fatty acids (especially unsaturated) and triacylglycerols contribute to the reconstruction and the repair of the cell membrane lipid bilayer during the gastric ulcer healing process.

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Effects of the stem barks aqueous extract of Anthocleista schweinfurthii Gilg (Loganiaceae) on acute and chronic gastric ulcers rats models

Cited by 3 publications

References 13 publications

Preclinical In vivo Acute Toxicity Testing of Hyrdoethanolic Extracts of Ficus thonningii Blume (Moraceae) on Wistar Rat Models

Preclinical In vivo Acute Toxicity Testing of Hyrdoethanolic Extracts of Ficus thonningii Blume (Moraceae) on Wistar Rat Models

Magnesium hydroxide nanoneedles derived fromAnthocleista schweinfurthiiGilg (Loganiaceae) support mesenchymal stromal cell proliferation and wound healing

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

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