Effects of thioctic acid on the glutathione redox cycle after cerebral ischemia-reperfusion in rats

Макеева, А. В.; Попова, Т. Н.

doi:10.1134/s1819712409020068

Cited by 5 publications

(6 citation statements)

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“…Since oxidative stress is associated with intensification of the glutathione system functioning requiring permanent NADPH delivery, previously revealed increase in G6PD and NADPH-isocitrate dehydrogenase activities in tissues of rats with postischemic brain reperfusion can be related to the necessity for delivery of reduced equivalents for functioning of this element of antiradical protection under conditions of oxidative stress [10]. Thus, activity of these enzymes expressed in U/g wet brain increased by 3.5 and 3.2 times (Fig.…”

Section: Resultsmentioning

confidence: 84%

“…Under conditions of oxidative stress, a pivotal role is played by activation of the glutathione system, an important component of the antioxidant system that deactivates organic and inorganic peroxides. Effi ciency of this system is limited by the concentration of NADPH produced by the key enzyme of the pentose phosphate pathway glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) and NADPH-isocitrate dehydrogenase (EC 1.1.1.42) [10].…”

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confidence: 99%

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Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion

et al. 2015

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Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehydrogenase) in animals with experimental hypoxia/reperfusion of the brain. These results can be explained by suppression of free radical oxidation and normalization of the antioxidant system related to the neuroprotective, antihypoxic, and antioxidant properties of these substances, their involvement into the regulation of cell metabolism under pathological conditions accompanied by oxidative stress.

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confidence: 84%

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confidence: 99%

Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion

et al. 2015

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“…Moreover, specifi c activity of these enzymes was also signifi cantly increased (Figs. 2 and 3) [6]. This was interrelated with intensifi cation of glutathione system functioning in response to oxidative stress, induced by disturbances in brain blood fl ow.…”

Section: Resultsmentioning

confidence: 96%

“…In addition, a signifi cant increase in specifi c activity of these enzymes was noted (Figs. 2 and 3) [6].…”

Section: Resultsmentioning

confidence: 98%

“…Under these conditions, the important adaptive role is played by antioxidant systems of the body, particularly by glutathione system responsible for deactivation of H 2 O 2 and organic peroxides acting as prooxidants. Effective functioning of this system requires NADPH supply, which may involve the key enzyme of pentose phosphate pathway glucose-6-phosphate dehydrogenase (G-6-PDH; EC 1.1.1.49) and NADP-isocitrate dehydrogenase (NADP-IDH; EC 1.1.1.42) [6].…”

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Effects of 2,4-Dimethoxyphenyl Biguanide on Glutathione System Activity in Rat Tissues in Brain Ischemia–Reperfusion

2011

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We studied the effects of dimethoxyphenyl biguanide on glutathione peroxidase and glutathione reductase activities, level of reduced glutathione in rat tissues, and activity of some NADPH-regenerating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) under conditions of ischemia-reperfusion of the brain. Administration of this biguanide derivative under pathological conditions led to a decrease in the analyzed parameters (elevated under conditions of ischemia-reperfusion) in the serum and brain tissue. The results attest to less pronounced mobilization of the glutathione system (compared to pathological state) due to antioxidant and protective properties of 2,4-dimethoxyphenyl biguanide under conditions of ischemic tissue damage associated with oxidative stress.

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Synthesis and effect of biguanide derivatives on biochemiluminescence and level of reduced glutathione in rat blood serum and brain under ischemia-reperfusion conditions

Попова¹,

Sukhoveeva²,

Макеева³

et al. 2011

Pharm Chem J

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We have studied the effect of the newly synthesized biguanides N-[amino(imino)methyl]morpholine-4carboximidamide (I) and N-[amino(imino)methyl]piperidine-1-carboximidamide (II) on biochemiluminescence (BCL) parameters including (i) lightsum (S) and maximum flash intensity (I max ), which characterize the level of free-radical processes, and (ii) the slope of the BCL kinetic curve (tan a 2 ), which characterizes general antioxidant activity, and on the reduced glutathione level in rats brain and blood serum under post-ischemic reperfusion conditions. It was found that the investigated parameters, which increased in response to the development of oxidative stress with brain pathology, changed toward normalization under the influence of the biguanides. A dose-dependent action of these substances has been established. The administration of I and II in 25 and 50 mg/kg led to the most pronounced decrease in the BCL parameters and reduced glutathione concentration while 12.5 and 75 mg/kg doses did not lead to significant changes in the studied parameters. The results show that biguanides introduced in certain doses can decrease the free-radical oxidation level and produce a neuroprotective effect.

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Effects of thioctic acid on the glutathione redox cycle after cerebral ischemia-reperfusion in rats

Cited by 5 publications

References 5 publications

Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion

Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion

Effects of 2,4-Dimethoxyphenyl Biguanide on Glutathione System Activity in Rat Tissues in Brain Ischemia–Reperfusion

Synthesis and effect of biguanide derivatives on biochemiluminescence and level of reduced glutathione in rat blood serum and brain under ischemia-reperfusion conditions

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