Effects of tributyltin on the immune system of Japanese flounder (Paralichthys olivaceus)

The trenbolone acetate affects the immune system in rainbow trout, Oncorhynchus mykiss

“…However, some effects of other androgenic disruptors on this enzymatic activity have been described by several authors. In contrast to our results, no effects on this enzyme activity were reported by Phumyu et al (2012) in male Nile tilapia (Oreochromis niloticus) with a dietary intake of 17␣-methyltestosterone (10 mg/Kg) and by Nakayama et al (2007) in Japanese flounder (Paralichthys olivaceus) exposed to tributyltin. We speculate, therefore, that the effects of androgenic compounds on plasma lysozyme activity are species-specific, dependent on the used compounds or on the route of administration.…”

“…In the kidney, neither lysozyme activity nor lysozyme mRNA expression was affected by TbA exposure. The same result was observed for the kidney lysozyme activity in Japanese flounder exposed to tributyltin (Nakayama et al, 2007). We thus speculate that, in teleosts, androgenic compounds do not alter the renal lysozyme activity.…”

“…11-KT inhibited the phagocytic cell functions (i.e., NO production and phagocytosis) in head-kidney phagocytic cells of carp in vitro (Yamaguchi and Watanuki, 2001) and in vivo (Watanuki et al, 2002). Tributyltin modulated, in vivo, the superoxide production and phagocytosis in the head-kidney leukocytes of rainbow trout (Nakayama et al, 2005) and Japanese flounder (Nakayama et al, 2007). Yamaguchi and Watanuki (2001) reported that this phagocytic modulation was dose-dependent.…”

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

“…Treatment with 11-ketotestosterone appears to suppress respiratory burst activity and phagocytosis in kidney macrophages (Yamaguchi et al 2001;Watanuki et al 2002;Kurtz et al 2007). The AR agonist tributyltin (TBT) impairs superoxide production and phagocytosis in the head kidney leukocytes (Harford et al 2005;Nakayama et al 2005Nakayama et al , 2007. Exposure of rainbow trout to the pesticide linuron, a classic mammalian anti-androgen, causes a decrease in phagocytic activity (Falk et al 1990).…”

“…However, the immune and inflammatory responses made part of the biological processes significantly down-regulated by treatment with the AR agonist trenbolone acetate (Garcia-Reyero et al 2009). Similarly, TBT induced a decline in lysozyme activity in Japanese flounder, Paralichthys olivaceus (Nakayama et al 2007). However, the effect of the AR antagonist p,p 0 -DDE on innate immune proteins in gilthead seabream, Sparus aurata, phagocytes was unclear in vitro (Cuesta et al 2008).…”