Effects of upper-body resistance exercise training on serum nesfatin-1 level, insulin resistance, and body composition in obese paraplegic men

Mogharnasi, Mehdi; TaheriChadorneshin, Hossein; Papoli-Baravati, Seyed Amin; Asma, Teymuri

doi:10.1016/j.dhjo.2018.07.003

Cited by 33 publications

(31 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been hypothesized that nesfatin-1 modifies glucose homeostasis by mechanisms that increase glucose uptake and insulin sensitivity (Li et al, 2013 ). A previous study demonstrated that serum nesfatin-1 and insulin sensitivity in obese men were increased after upper-body resistance exercise was conducted (Mogharnasi et al, 2019b ). Altogether, our results are consistent with the previous studies that showed an upsurge in nesfatin-1 and insulin sensitivity following high-intensity training (Ahmadizad et al, 2015 ; Ozcelik et al, 2018 ; Mogharnasi et al, 2019b ).…”

Section: Discussionmentioning

confidence: 99%

“…A previous study demonstrated that serum nesfatin-1 and insulin sensitivity in obese men were increased after upper-body resistance exercise was conducted (Mogharnasi et al, 2019b ). Altogether, our results are consistent with the previous studies that showed an upsurge in nesfatin-1 and insulin sensitivity following high-intensity training (Ahmadizad et al, 2015 ; Ozcelik et al, 2018 ; Mogharnasi et al, 2019b ). Moreover, another study reported that the reduction in nesfatin-1 induced by a high-fat diet is suppressed by the running wheel in mice (Chaolu et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

“…The underlying mechanism of the exercise-induced nesfatin-1 response is not well-documented. Nesfatin-1 is synthesized in the central and peripheral nervous system as well as in the adipose tissue and is subsequently released into the blood circulation (Mogharnasi et al, 2019b ). Nesfatin-1 exerts various actions at the level of nervous and digestive systems and plays a role in stress response and thermogenesis.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR

et al. 2020

View full text Add to dashboard Cite

Background/objective:This study aimed to investigate the impacts of a 12-week training of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the serum levels of nesfatin-1, irisin-1 and some other metabolic and anthropometric indices in overweight women with metabolic syndrome. Methods: Sixty overweight women with metabolic syndrome were assigned equally into four groups: aerobic exercise (AE, n = 15), resistance exercise (RE, n = 15), combined exercise (CE, n = 15), and control (n = 15). All groups underwent 12 weeks of intervention. The study variables were measured before and 24 h after the intervention period. Results: Twelve weeks of training resulted in an increase of irisin-1 in the AE and CE groups and nesfatin-1 in all the intervention groups. As expected, all the trained groups exhibited a positive alteration in anthropometric indices and lipid profile in comparison with the control group. Besides, compared with the control group, insulin resistance (based on the homeostatic model assessment) in AE (p = 0.022), RE (p = 0.032), and CE (p < 0.001) groups were reduced significantly. According to the observed changes in the measured indices, serum irisin-1 was significantly correlated with body weight, BMI, body fat percentage, fasting insulin, and HOMA-IR. However, with regard to nesfatin-1, only a negative correlation was observed with body fat percentage and LDL-cholesterol. Conclusions: The 12-week systematic training program changed circulating irisin-1 and nesfatin-1. Also, change in the serum irisin-1 and nesfatin-1 were correlated Amanat et al. Exercise and Nesfatin-1 and Irisin-1 with the change in glycemic and anthropometric indices in addition to LDL-cholesterol. Also, exercise training significantly reduced fasting insulin and HOMA-IR in all the intervention groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Nesfatin-1 may support insulin sensitivity. Nesfatin-1 treatment can decrease blood glucose level and improve insulin sensitivity (Mogharnasi et al, 2019). Hypothalamic nesfatin-1 action through a neuralmediated pathway can contribute to increased peripheral and hepatic insulin sensitivity by decreasing gluconeogenesis and promoting peripheral glucose uptake in vivo (Yang et al, 2012).…”

Section: Nesfatin-1 and Glucose Homeostasismentioning

confidence: 99%

Nesfatin-1: An Anorexigenic Peptid

2019

JSTR

View full text Add to dashboard Cite

Nesfatin-1 was identified as a potent anorexigenic peptide. Nesfatin-1 is expressed in the brain and peripheral tissues. Precursor of nesfatin-1 is nucleobindin-2 (NUCB2). This polypeptide is involved in the control of energy balance by food intake. Peripheral nesfatin-1 can potentially affect central nervous food intake regulation either via direct access to the brain. Circulating nesfatin-1 acts in the brain to influence food consumption, peripheral delivery of nesfatin-1may reduce food intake and body weight. Nesfatin-1 appears to contribute to the regulation of food intake by directly and/or indirectly affecting the integration of input and output signals between gut and brain. Nesfatin-1 is association with obesity and glucose homeostasis. Plasma levels of nesfatin-1 can correlate with body mass index, insulin resistance, fasting blood glucose, and fasting insulin levels, as well as with body weight and fat mass, suggesting that nesfatin-1, especially fat-derived nesfatin-1, may play an important rol in human metabolism and food intake. In addition to, lipid accumulation may be reduced by nesfatin-1in cultured hepatocytes. In conclusion, it can be said that nesfatin-1 is not only associated with food intake but also with obesity, insulin resistance and type 2 diabetes.

show abstract

“…Exercise has numerous influences on multiple gut peptides and consequently energy balance (Dorling et al, 2018). Studies have investigated the effects of different modes of exercise training on PGC-1α (Dinas et al, 2017;Jung and Kim, 2014;Norheim et al, 2014), irisin (Dinas et al, 2017;Norheim et al, 2014;Samy et al, 2015), nesfatin-1 (Algul et al, 2017;Ghanbari Niaki et al, 2013b;Ghanbari-Niaki et al, 2010;Mogharnasi et al, 2018) and resistin (Cobbold, 2018;Shafiee and Sharifi, 2017;García-Hermoso et al, 2017). However, the effects of HMB on these factors have not been investigated widely.…”

Section: Introductionmentioning

confidence: 99%

Eccentric resistance training and β-Hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin

Shirvani

Rahmati-Ahmadabad

Broom

et al. 2019

Journal of Experimental Biology

View full text Add to dashboard Cite

The hypothalamus controls metabolism and feeding behaviour via several signals with other tissues. Exercise and supplements can change hypothalamic signalling pathways, so the present study investigated the influence of eccentric resistance training and β-hydroxy-β-methylbutyrate free acid supplementation on PGC-1α expression, serum irisin, nesfatin-1 and resistin concentrations. Thirty-two male rats (8 weeks old, 200±17 g body mass) were randomly allocated to control, β-hydroxy-β-methylbutyrate free acid supplementation (HMB), eccentric resistance training (ERT), and β-hydroxy-β-methylbutyrate free acid supplementation plus eccentric resistance training (HMB+ERT) groups. Training groups undertook eccentric resistance training (6 weeks, 3 times a week) and supplement groups consumed β-hydroxy-β-methylbutyrate free acid (HMB-FA) orally (76 mg kg −1 day −1 ). Twenty-four hours after the last training session, serum and triceps brachii muscle samples were collected and sent to the laboratory for analysis. Two-way ANOVA and Pearson correlation were employed (significance level: P<0.05). The results showed that eccentric resistance training increases skeletal muscle PGC-1α gene expression, as well as serum levels of irisin and nesfatin-1 (P=0.001). Eccentric resistance training decreased the serum concentration of resistin (P=0.001). HMB-FA supplementation increased skeletal muscle PGC-1α gene expression (P=0.002), as well as the serum concentration of irisin and nesfatin-1 (P=0.001), but decreased the serum concentration of resistin (P=0.001). Significant correlations were observed between PGC-1α gene expression and serum concentrations of irisin, nesfatin-1 and resistin. HMB-FA supplementation with eccentric resistance training may induce crosstalk between peptide release from other tissues and increases maximal muscle strength. The combination of the two interventions had a more substantial effect than each in isolation.

show abstract

Effects of upper-body resistance exercise training on serum nesfatin-1 level, insulin resistance, and body composition in obese paraplegic men

Cited by 33 publications

References 46 publications

A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR

A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR

Nesfatin-1: An Anorexigenic Peptid

Eccentric resistance training and β-Hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin

Contact Info

Product

Resources

About