Effects of Various Coumarins from Roots of Angelica dahurica on Actions of Adrenaline, ACTH and Insulin in Fat Cells

Kimura, Yoshiyuki; Ohminami, Hiroji; Arichi, Hideko; Okuda, Hiroyuki; K, Baba; Kozawa, Mitsugi; Arichi, Shigeru

doi:10.1055/s-2007-971370

Cited by 35 publications

(29 citation statements)

References 6 publications

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“…In Traditional Chinese Medicine, the roots of A. dahurica have been used to treat headache, rhinitis, cold and toothache amongst others. Furthermore, pharmacological studies have shown that it has antimicrobial (11), hepatoprotective (12), antioxidative (13) and cholinesterase inhibitory activities (14), and activates dendritic cells (15) and the actions of lipolytic hormones (16). Furthermore, it inhibits the production of prostaglandin E 2 (17) and nitric oxide (NO) (18,19), and reduces the release of histamine (20).…”

Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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Abstract. Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β-sitosterol (14) and daucosterol (15). Compounds 1-13 were able to reduce the release of histamine, with compounds 4-6 exhibiting the most potent activity. Furthermore, compounds 1-12 were able to inhibit the secretion of tumor necrosis factor-α, interleukin (IL)-1β and IL-4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor-κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H 1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.

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Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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“…and an isotretronic acid derivative that imparts its characteristic odor to this drug, 2) and the effects of furanocoumarins isolated on the actions of adrenaline, adrenocorticotropic hormone (ACTH), insulin in fat cells isolated from rats, 3) histamine release in the mouse peritoneal cavity, 4) and human microsomal cytochrome P450 3A activity. 5) Continued investigation of the coumarin components resulted in the isolation of five new spirobifuranocoumarins, dahuribirins A-E (1-5) and two bifuranocoumarins, dahuribirins F and G (6, 7) by repeated chromatographic separation from this natural medicine.…”

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confidence: 99%

Seven New Bifuranocoumarins, Dahuribirin A-G, from Japanese Bai Zhi.

Wang

Yoshizaki

2001

Chem. Pharm. Bull.

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“…To calculate the administered dose, the contents of eight coumarins in radix Angelicae dahuricae extract solution were determined by external standard method using the same chromatography conditions as described above. The contents of the eight coumarins (1)(2)(3)(4)(5)(6)(7)(8) in the extract were 540, 117, 74, 224, 361, 1210, 1860, 1600 μg/mL, respectively.…”

Section: Preparation Of Radix Angelicae Dahuricae Extractmentioning

confidence: 98%

“…[3]. Pharmacological studies have demonstrated that they have shown a variety of biological effects, such as antioxidative activity [4], antihistamine [5], antibacterial action [6,7], spasmolysis [8], and treatment of chronic venous insufficiency [9].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous and sensitive determination of eight coumarins in rat bile and urine after oral administration ofRadix Angelicae Dahuricaeextract by liquid chromatography-electrospray ionization-mass spectrometry

Huo¹,

Yu²,

Liu³

et al. 2013

Acta Chromatographica

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Summary.A selective and sensitive liquid chromatography-electrospray ionizationmass spectrometry (HPLC-ESI-MS) method was developed and validated for analysis of xanthotoxol (1), xanthotoxin (2), isoimpinellin (3), bergapten (4), oxypeucedanin (5), imperatorin (6), cnidilin (7), and isoimperatorin (8) in rat bile and urine using pimpinellin as an internal standard (IS). An Agilent 1200 liquid chromatography system (Agilent Technologies, USA) equipped with a quaternary pump, an autosampler, and a column compartment was used for all analyses. Chromatographic separations were performed on a Sapphire C 18 column (150 mm × 4.6 mm, 5 μm), and the column temperature was maintained at 30°C; the sample injection volume was 10 μL. The specificity, linearity, accuracy, precision, recovery, matrix effect, and several stabilities were validated for all analytes in the rat bile and urine samples. The method was successfully applied in monitoring the concentrations of eight coumarins in rat bile and urine after a single oral administration of Radix Angelicae Dahuricae extract with a dosage of 8.0 mL/kg. In the bile samples, the eight coumarins excreted completely in twenty-four hours. The average percentages of coumarins (1-8) excreted were 0.045%, 0.019%, 0.177%, 0.105%, 0.337%, 0.023%, 0.024%, 0.021%. In the urine samples, the eight coumarins excreted completely in seventy-two hours. The average percentages of coumarins (1-8) excreted were 1.78%, 0.095%, 0.130%, 0.292%, 0.082%, 0.008%, 0.005%, 0.004%. The method is robust and specific and it can successfully complete the requirements of the excretion study of the eight coumarins in Radix Angelicae Dahuricae.

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Effects of Various Coumarins from Roots of Angelica dahurica on Actions of Adrenaline, ACTH and Insulin in Fat Cells

Cited by 35 publications

References 6 publications

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Seven New Bifuranocoumarins, Dahuribirin A-G, from Japanese Bai Zhi.

Simultaneous and sensitive determination of eight coumarins in rat bile and urine after oral administration ofRadix Angelicae Dahuricaeextract by liquid chromatography-electrospray ionization-mass spectrometry

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