Seven New Bifuranocoumarins, Dahuribirin A-G, from Japanese Bai Zhi.

Simultaneous Characterisation of Fifty Coumarins from the Roots ofAngelica dahuricaby Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry

“…Group III: dimers of LFCs. Dimers of LFCs are a class of structurally interesting natural products, and most of this kind compound have been isolated from plants belonging to the Umbelliferae (Taniguchi et al, 1998(Taniguchi et al, , 1999(Taniguchi et al, , 2000Zhou et al, 2000;Wang et al, 2001;Nakamori et al, 2008). According to the condensation path of the two monomers, dimers of LFCs are divided into two types, as shown in Fig.…”

“…The root of A. dahurica is a well‐known herbal medicine used for the treatment of headache, toothache, abscess, furunculosis and acne (Chinese Pharmacopeia Committee, ). Given that A. dahurica has diverse and important pharmacological properties, intensive investigations focusing on screening the bioactive constituents from A. dahurica have been carried out leading to the separation and structural elucidation of bioactive components (Baek et al ., ; Wang et al ., ; Kwon et al ., ; Lee et al ., ; Sarker and Nahar, ; Zhao et al ., , ; Jia et al ., ; Liu et al ., ), among which coumarins were the major bioactive constituents, indicating anti‐tumour, anti‐bacterial, anti‐oxidative, anti‐inflammatory and estrogenic (Kwon et al ., ; Lin et al ., ; Thanh et al ., ; Piao et al ., ; Hua et al ., ; Thuong et al ., ;). However, the conventional methods for screening bioactive constituents and structural elucidation were mainly achieved by column chromatography and spectroscopic techniques, which are laborious and time consuming, and especially the successful preparations of trace components are still challenging.…”

β‐secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica

“…The root of this species has been used in Korea as a traditional folk medicine to treat headache, bleeding, menstrual disorder and neuralgia (Kimura et al, 1996). Earlier investigations on the chemical constituents of A. dahurica dealt with the isolation of over 20 coumarins (Kwon et al, 2002;Wang et al, 2001;Baek et al, 2000;Qiao et al, 1996;Kim et al, 1992). This paper reports the isolation and identifi cation of the BACE1 inhibitors from the root of A. dahurica.…”

Furocoumarins in Medicinal Chemistry. Synthesis, Natural Occurrence and Biological Activity

“…The sources of these compounds are presented in Tables I-VI. Table I shows 3-, 5-and/or 8-substituted psoralens; Table II shows 4',5'-dihydropsoralens substituted in any position; Table III shows angelicins and Table IV In recent years a large number of dimers (birins) and trimers (tririns) have been isolated and characterised and these were obtained from the species' Angelica dahurica [88] and Pleurospermun rivulorum [89][90][91][92][93][94]. These systems are all formed by linear furocoumarins linked to one another by isoprenoid chains bonded to the oxygenated positions of the psoralens, generally at position 2 (through the oxygen atom of the carbonyl group from the pyrone ring) and/or position 8: Dahuribirins A-G [88]; Rivulobirins A-B [91], C-D [92], E [89], and F-J [94]; Cyclorivulobirins A-C [90], and Rivulotririns A-B [93] and C [89].…”