Effects of Various Thiol Molecules Added on Morphology of Dendrimer–Gold Nanocomposites

Satoh, Kazumi; Yoshimura, Tomokazu; Esumi, Kunio

doi:10.1006/jcis.2002.8585

Cited by 17 publications

(13 citation statements)

References 15 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Dendrimers represent a key stage in the ongoing evolution of macromolecular chemistry, which is a result of the wide range of applications that have been foreseen for such materials in biomedical science. Applications have included solubility enhancement, [16][17][18][19] MRI contrast agents, [20][21][22][23][24][25][26][27] neutron capture therapy, [28][29][30][31][32][33][34] gene therapy, [35][36][37][38][39][40][41] drug delivery, [42][43][44] nanocomposites, [45][46][47][48] and photodynamic therapy. [49]…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Introductionmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…Figure 2 indicates that all samples have a unique absorption peak in the range of 520 -540 nm [10] [34], which reveals the formation of AuNPs. Plasmonic peak around 520 nm corresponds to the collective oscillation of gold free electrons [35].…”

Section: Uv-vis Evaluationmentioning

confidence: 98%

“…Esumi et al believe that the interactions of Au-NPs with amine terminated den- drimers are stronger than carboxyl terminated dendrimers as the FTIR bands of dendrimer are shifted while the half generations do not show any changes [10] [48]. Furthermore, according to [34] the FTIR and UV-vis evaluations of dendrimer depend on the size and their generations, at lower generations' external type and at higher generations a mixed type could be observed.…”

Section: Ftir and Wdx Evaluationmentioning

confidence: 99%

Imaging and Therapeutic Applications of Optical and Thermal Response of SPION-Based Third Generation Plasmonic Nanodendrimers

Tajabadi¹,

Khosroshahi²,

Bonakdar³

2015

OPJ

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In this study, 9 nm superparamagnetic iron oxide nanoparticles (SPION) were functionalized by polyamidoamine (PAMAM) dendrimer. Using tetracholoroauric acid (HAuCl 4 ), magnetodendrimer (MD) samples were conjugated by gold nanoparticles (Au-NPs). Two different reducing agents, i.e. sodium borohydride and hydrazine sulfate, and pre-synthesized 10-nm Au-NP were used to evaluate the efficiency of conjugation method. The samples were characterized using X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, UV-visible spectroscopy and fluorescence spectroscopy. The results confirmed that AuNPs produced by sodium borohydrate and the pre-synthesized 10-nm Au-NPs were capped by MDs whereas the Au-NP prepared by hydrazine sulfate as a reducing agent was entrapped by MDs. Optical properties of the MDs were studied by laser-induced fluorescence spectroscopy (LIF) within a wide range of visible spectrum. Also, based on the thermal analysis, all synthesized nanostructures exhibited a temperature increase using 488 nm and 514 nm wavelengths of a tunable argon laser. The new iron oxide-dendrimer-Au NPs synthesized by sodium borohydrate (IDANaBH4) produced the highest temperature increase at 488 nm whereas the other nanostructures particularly pure Au-NPs produced more heating effect at 514 nm. These findings suggest the potential application of these nanocomposites in the field of bioimaging, targeted drug delivery and controlled hyperthermia. M. Tajabadi et al.213

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“…Dendritic macromolecules have a nano‐sized, homogeneous, and monodisperse structure consisting of tree‐like branches . Because of their highly branched architecture, dendrimer‐based systems are potentially useful for many applications including drug delivery, nanocomposites, scaffolds, cell adhesion, and coatings . Recent studies revealed various hydrogels formed from these dendritic macromolecules by physical (hydrogen bonding, ionic association, and host‐guest complexation) or chemical crosslinking (photopolymerization and condensation/addition reactions) for various biomedical applications .…”

Section: Figurementioning

confidence: 99%

A Supramolecular Hydrogel Based on Polyglycerol Dendrimer‐Specific Amino Group Recognition

Cho

Ooya

2018

Chemistry An Asian Journal

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Dendrimer-based supramolecular hydrogels have gained attention in biomedical fields. While biocompatible dendrimers were used to prepare hydrogels via physical and/or chemical crosslinking, smart functions such as pH and molecular control remain undeveloped. Here, we present polyglycerol dendrimer-based supramolecular hydrogel formation induced by a specific interaction between the polyglycerol dendrimer and an amino group of glycol chitosan. Gelation was achieved by mixing the two aqueous solutions. Hydrogel formation was controlled by varying the polyglycerol dendrimer generation. The hydrogel showed pH-dependent swelling; strongly acidic conditions induced degradation via dissociation of the specific interaction. It also showed unique l-arginine-responsive degradation capability due to competitive exchange of the amino groups of glycol chitosan and l-arginine. These polyglycerol dendrimer-based supramolecular characteristics allow multimodal application in smart biomaterials.

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Effects of Various Thiol Molecules Added on Morphology of Dendrimer–Gold Nanocomposites

Cited by 17 publications

References 15 publications

Dendritic Polyglycerols for Biomedical Applications

Dendritic Polyglycerols for Biomedical Applications

Imaging and Therapeutic Applications of Optical and Thermal Response of SPION-Based Third Generation Plasmonic Nanodendrimers

A Supramolecular Hydrogel Based on Polyglycerol Dendrimer‐Specific Amino Group Recognition

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