Effects of Vasodilator Drugs and Other Procedures on Digital Cutaneous Blood Flow, Cardiac Output, Blood Pressure, Pulse Rate, Body Temperature, and Metabolic Rate

Horwitz, Orville; Montgomery, H. E.; Longaker, Edwin Downs; Sayen, Ann

doi:10.1097/00000441-194921860-00009

Cited by 41 publications

(4 citation statements)

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“…of 86 proof alcohol which was less marked in patients suffering from arterial disease than in normal subjects. Horwitz, Montgomery, Longaker & Sayen (1949) postulated that, since blood pressure and cardiac output remained unchanged after oral whisky, the vasodilatation in skin must be accompanied by a vasoconstriction elsewhere, but no direct evidence of a constrictor action of alcohol on blood vessels is available.…”

mentioning

confidence: 99%

The Effects of Ethyl Alcohol on the Blood Vessels of the Hand and Forearm in Man

Fewings

Hanna

Walsh

et al. 1966

British Journal of Pharmacology and Chemotherapy

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mentioning

confidence: 99%

The Effects of Ethyl Alcohol on the Blood Vessels of the Hand and Forearm in Man

Fewings

Hanna

Walsh

et al. 1966

British Journal of Pharmacology and Chemotherapy

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“…This agrees with the general observation that the peripheral circulation of the foot responds less to vasomotor stimuli than the hand (Rothman 1954, Schwiegk 1950. Accordingly, there is considerably less vasodilatation in the foot than in the hand after alcohol administration (Horton et al 1936, Horwitz et al 1949, Rothman 1954, Schulze 1947 , although alcohol seems to increase the toe temperature in the cold (Little 1970). The effect of smoking is also less in the foot (Larson ~t al.…”

Section: Discussionmentioning

confidence: 99%

Effects of Alcohol, Hot Drinks, or Smoking on Hand and Foot Heat Loss

Goldman¹,

Newman²,

Wilson³

1973

Acta Physiologica Scandinavica

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Using precision calorimetric techniques for measuring extremity heat loss, possible contraindications or advantages of alcoholic or hot drinks or smoking just prior to cold exposure were assessed. Ten subjects were given 60‐min exposures with one hand and one foot immersed in 15° C water, following the drinking of 1. 200 ml of 23° C water (control), 2. 200 ml of 23° C water containing 22 ml of absolute alcohol, 3. 200 ml of 55° C bouillon, 4. 200 ml of 23° C water and smoking 2 cigarettes. No significant effects were noted in the foot, but significant differences were observed in hand heat loss to the calorimeter; smoking depressed hand heat loss, alcohol elevated it. Smoking had a persistent influence, but the effect of alcohol had disappeared after 30 min. Bouillon had an effect similar to alcohol, but of shorter duration, and also resulted in a significantly reduced heat loss after 30 min. Alcohol produced a significantly higher amount of cold induced vasodilatation (CIVD) with greater total temperature elevation in 3 fingers than did smoking, although smoking did not prevent CIVD. With intake of bouillon, CIVD appeared earlier than with alcohol, and during the 1st 15 min, total temperature elevation in the 3 fingers was markedly higher than in the control run, but not as large as with alcohol. All differences were relatively small and would seem to be of little practical importance.

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“…These are not changed when therapeutic doses are used. "- 95 Skin circulation. The effect on the circulation of the skin is variable, but there is often a slight increase in the temperature of the fingers without an increase in the temperature of the toes'": occasionally, however, it decreases.…”

Section: Indications Phenoxybenzamine Has Beenmentioning

confidence: 99%

Clinical pharmacology of vasodilating drugs

Winsor

Hyman

1961

Clin Pharma and Therapeutics

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The human pharmacology of oasodilaiors and their total cardiovascular effect are reviewed. Emphasis is placed on the peripheral circulation through skin and muscle; cardiac output, blood pressure, and circulation through the lungs, kidneys, lioer, eyes, and splanchnic areas are also surveyed. Objective methods for studying the oasodilators in man are described in sufficient detail to make objective eoaluation understandable. Laboratory studies are examined in the light of clinical observations, and the combined information seroes as a basis for establishing indications for the use of these drugs.

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Effects of Vasodilator Drugs and Other Procedures on Digital Cutaneous Blood Flow, Cardiac Output, Blood Pressure, Pulse Rate, Body Temperature, and Metabolic Rate

Cited by 41 publications

References 0 publications

The Effects of Ethyl Alcohol on the Blood Vessels of the Hand and Forearm in Man

The Effects of Ethyl Alcohol on the Blood Vessels of the Hand and Forearm in Man

Effects of Alcohol, Hot Drinks, or Smoking on Hand and Foot Heat Loss

Clinical pharmacology of vasodilating drugs

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