2009
DOI: 10.1007/s00210-009-0400-5
|View full text |Cite
|
Sign up to set email alerts
|

Effects of verbascoside biotechnologically produced by Syringa vulgaris plant cell cultures in a rodent model of colitis

Abstract: The aim of the present study was to examine the effects of verbascoside (VB) in rats subjected to experimental colitis. Colitis was induced in rats by intracolonic instillation of 2,4 dinitrobenzene sulfonic acid (DNBS; 25 mg/rat). VB was administered daily per os (0.2 and 2 mg/kg) 4 days after DNBS administration in the colon. Treatment with VB significantly (P < 0.01) reduced macroscopic damage score, loss of body weight, myeloperoxidase activity and thiobarbituric acid-reactant substances. Moreover, the int… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
32
0

Year Published

2009
2009
2020
2020

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 40 publications
(33 citation statements)
references
References 32 publications
1
32
0
Order By: Relevance
“…This neutrophil mobilisation could be related to the effect of DSS on blood polymorphonuclear cell numbers. A recent study reported a protective effect of verbascoside administered per os (0.2 and 2 mg/kg) on MPO activity in rats with DNBS-induced colitis [19]. Moreover, i.p.-injected verbascoside (&30 mg/kg/day) in mice failed to reduce the MPO activity in acute DSS-induced colitis but reduced it in chronic DSS-induced colitis [20].…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…This neutrophil mobilisation could be related to the effect of DSS on blood polymorphonuclear cell numbers. A recent study reported a protective effect of verbascoside administered per os (0.2 and 2 mg/kg) on MPO activity in rats with DNBS-induced colitis [19]. Moreover, i.p.-injected verbascoside (&30 mg/kg/day) in mice failed to reduce the MPO activity in acute DSS-induced colitis but reduced it in chronic DSS-induced colitis [20].…”
Section: Discussionmentioning
confidence: 99%
“…However, inflammation tended to induce a slight increase of the TNF-a level in the colon that was corrected by lemon verbena infusion consumption. Verbascoside has been shown to exert a beneficial effect on the TNF-a level in a DNBS model [19].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…An extract from Lippia citriodora leaves standardized to 20% (w/w) of verbascoside (VB; Figure 1), was used (Mazzon et al, 2009). The antioxidant supplement was prepared on an industrial scale by a standardized procedure that includes ultrasonic extraction with 60% aqueous ethyl alcohol followed by spray-drying with maltodextrins as an excipient.…”
Section: Animals and Dietsmentioning
confidence: 99%