“…Nevertheless, beneficial effects of various polyphenols on colonic histological structure have often been reported. Purified verbascoside improved the histopathological lesions induced by the intrarectal administration of 2,4-dinitrobenzene sulfonic acid (DNBS) [19], while diet supplementation with resveratrol or curcumin also decreased mucosal erosion in trinitrobenzene sulfonic acid (TNBS) and DSS models [31,33,34]. Conversely, the histological score worsened in a DSS mouse model after diet supplementation with a high dose of luteolin (32 mg/mouse/day) [35].…”