Lemon Verbena Infusion Consumption Attenuates Oxidative Stress in Dextran Sulfate Sodium-Induced Colitis in the Rat

Lenoir, Loïc; Rossary, Adrien; Joubert‐Zakeyh, Juliette; Vergnaud-Gauduchon, Juliette; Farges, Marie‐Chantal; Fraisse, Didier; Texier, Odile; Lamaison, Jean‐Louis; Vasson, Marie‐Paule; Felgines, Catherine

doi:10.1007/s10620-011-1784-x

Cited by 40 publications

(26 citation statements)

References 45 publications

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“…However, a study using a cocoa diet in a dextran sodium sulfate (DSS) model demonstrated that cocoa intake did not improve clinical colitis, although it certainly contributed to reducing colonic oxidative activity and serum inflammatory mediator concentrations (Pérez-Berezo et al, 2012a). These results agree with those obtained with luteolin and with a lemon verbena infusion rich in polyphenolic compounds (Karrasch et al, 2007; Lenoir et al, 2011). More interestingly, it has recently been reported that a polyphenol-enriched cocoa extract was able to decrease acute DSS colitis in mice (Andújar et al, 2011), thus evidencing the need for a high polyphenol content in the cocoa to achieve anti-inflammatory activity in the IBD.…”

Section: Anti-inflammatory Potential Of Cocoasupporting

confidence: 91%

The effects of cocoa on the immune system

Pérez-Cano¹,

Massot-Cladera²,

Franch³

et al. 2013

Front. Pharmacol.

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Cocoa is a food relatively rich in polyphenols, which makes it a potent antioxidant. Due to its activity as an antioxidant, as well as through other mechanisms, cocoa consumption has been reported to be beneficial for cardiovascular health, brain functions, and cancer prevention. Furthermore, cocoa influences the immune system, in particular the inflammatory innate response and the systemic and intestinal adaptive immune response. Preclinical studies have demonstrated that a cocoa-enriched diet modifies T cell functions that conduce to a modulation of the synthesis of systemic and gut antibodies. In this regard, it seems that a cocoa diet in rats produces changes in the lymphocyte composition of secondary lymphoid tissues and the cytokines secreted by T cells. These results suggest that it is possible that cocoa could inhibit the function of T helper type 2 cells, and in line with this, the preventive effect of cocoa on IgE synthesis in a rat allergy model has been reported, which opens up new perspectives when considering the beneficial effects of cocoa compounds. On the other hand, cocoa intake modifies the functionality of gut-associated lymphoid tissue by means of modulating IgA secretion and intestinal microbiota. The mechanisms involved in these influences are discussed here. Further research may elucidate the cocoa compounds involved in such an effect and also the possible medical approaches to these repercussions.

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Section: Anti-inflammatory Potential Of Cocoasupporting

confidence: 91%

The effects of cocoa on the immune system

Pérez-Cano¹,

Massot-Cladera²,

Franch³

et al. 2013

Front. Pharmacol.

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show abstract

“…56,57 Surprisingly, the amount of glutathione in its reduced (GSH) and oxidized (GSSG) forms in inflamed colon was not affected by colitis, despite presumed intense production of reactive oxygen and nitrogen oxidative species. 58 These results that were already observed in previous studies using the model of DSS-induced colitis, 49,50,59 suggest that the colonic content in glutathione can be dissociated from regulating major inflammation, at least in this experimental model.…”

Section: Discussionsupporting

confidence: 66%

“…Indeed, most studies have focused on the effects of dietary supplementation before and/or during the induction of colitis. 39,[49][50][51][52] This is related to the fact that only recently has emerged MH as a therapeutic goal that would allow diminishing the risk of relapse in patients in remission for IBD. 8 , colitis was induced in rats by adding DSS in the drinking water for 6 days.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of an Amino Acid Mixture on Colonic Mucosal Healing in Rats

Liu

Beaumont

Walker

et al. 2013

Inflammatory Bowel Diseases

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“…28 Previous research has only investigated the dynamic parameters of their free radical scavenging activities with respect to hydroxyl radical scavenging, so new data are needed for other radicals. VO is widely used for the treatment of anxiety and unrest.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Comparison of Free Radical Scavenging Abilities of Hypericum Perforatum L., Herba Verbenae Officinalis, and Valeriana Officinalis L. Extracts

Li¹,

Liu²,

Xiao³

et al. 2015

Phcog J

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Objectives: The purpose of this research was to compare the dynamic antioxidant activities and the free radical scavenging abilities of three botanical supplements, Hypericum perforatum L. (HPL), Herba Verbena Officinalis (HVO), and Valeriana officinalis L. (VO), which have been reported to effectively treat menopause symptoms. Methods: The antioxidant activities of the three supplements were determined by the ferric reducing ability of plasma (FRAP) assay. In addition, their free radical scavenging abilities were studied by ftheir interactions with the stable radicals of 2, 2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). Results: The results indicated that the HPL ethanolic extract exhibited greater antioxidant activity (1.2688 ± 0.01 mmol Trolox/g) than the HVO ethanolic extract (1.1686± 0.043 mmol Trolox/g) and the VO ethanolic extract (0.2579 ± 0.0031 mmol Trolox/g) as compared to Nilestriol (0.0026±0.0012), a positive control agent in the experiment. Moreover, the HPL extract showed remarkable free radical scavenging activity against ABTS•+, and the HVO extract was the most potent against DPPH•. Conclusion: These activities may be attributed to the total flavonoid or phenolic acid contents of among these extracts.

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Lemon Verbena Infusion Consumption Attenuates Oxidative Stress in Dextran Sulfate Sodium-Induced Colitis in the Rat

Abstract: Our study shows that the preventive consumption of lemon verbena infusion offered some antioxidative protection during experimental colitis by stimulating SOD activity and decreasing lipid peroxidation.

Cited by 40 publications

References 45 publications

The effects of cocoa on the immune system

The effects of cocoa on the immune system

Beneficial Effects of an Amino Acid Mixture on Colonic Mucosal Healing in Rats

Dynamic Comparison of Free Radical Scavenging Abilities of Hypericum Perforatum L., Herba Verbenae Officinalis, and Valeriana Officinalis L. Extracts

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