Effects of vitamins E and C combined with β-carotene on cognitive function in the elderly

Li, Yonghua; Liu, Shumei; Man, Yigang; Li, Ning; Zhou, Yuanyuan

doi:10.3892/etm.2015.2274

Cited by 24 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, a randomized control trial involving 276 elderly participants demonstrated that 16-week-co-supplementation of vitamin E and C with β-carotene significantly improved cognitive function (particularly with higher doses of β-carotene). Furthermore, the authors suggested that such a treatment markedly reduced plasma Aβ levels and elevated plasma estradiol levels [ 80 ]. Vit C and E co-supplementation for more than 3 years was also shown to be associated with a reduced prevalence and incidence of AD [ 81 ].…”

Section: Role Of Vitamin C In Neurodegenerative Diseasesmentioning

confidence: 99%

Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

et al. 2017

View full text Add to dashboard Cite

Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders.

show abstract

Section: Role Of Vitamin C In Neurodegenerative Diseasesmentioning

confidence: 99%

Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Some of the most important carotenoids in terms of biotechnological and biomedical uses explored so far are: Astaxanthin (3,3′-dihydroxy-β,β′-carotene-4,4′-dione) [ 36 , 39 , 40 ], β-Carotene (β,β-carotene) [ 38 , 41 , 42 , 43 , 44 ], Canthaxanthin (β,β-carotene-4,4′-dione) [ 45 , 46 , 47 , 48 ], β-Cryptoxanthin (hydroxy-β-carotene) [ 38 , 49 , 50 , 51 , 52 , 53 , 54 ], Fucoxanthin [ 38 , 55 ], Lycopene (ψ,ψ-carotene) [ 33 , 56 , 57 ], Lutein (β,ε-carotene-3,3′-diol) [ 42 , 58 , 59 , 60 , 61 ], Zeaxanthin (β,β-carotene-3,3′-diol) [ 38 , 62 , 63 ], and Violaxanthin (5,6:5′,6′-diepoxy-5,5′,6,6′-tetrahydro-β-carotene-3,3′-diol) [ 64 , 65 , 66 , 67 , 68 ].…”

Section: Carotenoids: Structure and Functionalitymentioning

confidence: 99%

Carotenoids from Haloarchaea and Their Potential in Biotechnology

et al. 2015

View full text Add to dashboard Cite

The production of pigments by halophilic archaea has been analysed during the last half a century. The main reasons that sustains this research are: (i) many haloarchaeal species possess high carotenoids production availability; (ii) downstream processes related to carotenoid isolation from haloarchaea is relatively quick, easy and cheap; (iii) carotenoids production by haloarchaea can be improved by genetic modification or even by modifying several cultivation aspects such as nutrition, growth pH, temperature, etc.; (iv) carotenoids are needed to support plant and animal life and human well-being; and (v) carotenoids are compounds highly demanded by pharmaceutical, cosmetic and food markets. Several studies about carotenoid production by haloarchaea have been reported so far, most of them focused on pigments isolation or carotenoids production under different culture conditions. However, the understanding of carotenoid metabolism, regulation, and roles of carotenoid derivatives in this group of extreme microorganisms remains mostly unrevealed. The uses of those haloarchaeal pigments have also been poorly explored. This work summarises what has been described so far about carotenoids production by haloarchaea and their potential uses in biotechnology and biomedicine. In particular, new scientific evidence of improved carotenoid production by one of the better known haloarchaeon (Haloferax mediterranei) is also discussed.

show abstract

“…However, there was only borderline or little evidence of a cognitive benefit from use of antioxidant supplements, particularly vitamins C and E, according to at least six independent cohort studies [ 54 , 60 , 84 , 85 , 86 , 87 ], and several cross-sectional studies [ 61 , 84 ]. Nevertheless, at least a few randomized controlled trials (RCTs) have indicated a benefit from supplementation with vitamin C [ 88 ], particularly among non-smokers [ 89 ], or from a combination of various antioxidants (including vitamins C, E, and β-carotene) [ 90 , 91 ], while other RCTs that focused on vitamin E supplementation failed to do so [ 92 , 93 , 94 ]. In our study, adjustment for supplemental intake of antioxidants did not alter the key findings with dietary antioxidants as the main exposures.…”

Section: Discussionmentioning

confidence: 99%

Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults

Beydoun

Canas²,

Kuczmarski

et al. 2020

Nutrients

View full text Add to dashboard Cite

Carotenoids may strengthen the association of antioxidant vitamins A, C, and E with favorable cognitive outcomes over time, though a few prospective studies have examined this hypothesis. We evaluated the longitudinal data from 1251 participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (Age at visit 1 in 2004–2009 (v1): 30–65 years). Vitamins A, C, and E dietary intakes and total and individual dietary carotenoids were computed using two 24-h recalls at v1. Cognitive tests, covering global mental status and domains of memory/learning, attention, psychomotor speed, visuo-spatial, language/verbal, and executive function were conducted at v1 and/or v2 (2009–2013); mean ± SD follow-up: 4.66 ± 0.93 years. Mixed-effects linear regression models detected an interaction between vitamin E and total (and individual) carotenoids for three of 11 cognitive tests at v1, with only one meeting the statistical significance upon multiple testing correction whereby vitamin E was linked with greater verbal memory performance in the uppermost total carotenoid tertile (γ0a = +0.26 ± 0.08, p = 0.002), a synergism largely driven by carotenoid lycopene. Vitamins A and C showed no consistent interactions with carotenoids. In conclusion, we provide partial evidence for synergism between vitamin E and carotenoids in relation to better baseline cognitive performance, pending further studies with time-dependent exposures and randomized trials directly examining this synergism.

show abstract

Effects of vitamins E and C combined with β-carotene on cognitive function in the elderly

Cited by 24 publications

References 32 publications

Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Carotenoids from Haloarchaea and Their Potential in Biotechnology

Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults

Contact Info

Product

Resources

About