Effects of Yishenjiangzhuo granules on immunity and bone metabolism in patients with stage 3-4 chronic kidney disease

Zheng, Jing; Lin, Yingda; Huang, Lu; Chen, Caifeng; Zheng, Xiaoyan; Wu, Xinhong; Liu, Ciyun

doi:10.1016/s0254-6272(14)60031-5

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…In China, TCM has been in practice for thousands of years in the treatment of CRF and has showed number of remarkable results (Lu et al, 2018; Mei, Yang, Wang, & Wang, 2021). Buxu Xiaozheng recipe is a TCM preparation developed by famous and experienced TCM doctors, which previously reported to delay renal interstitial fibrosis progression by modulating the levels of inflammatory factors and oxidative stress in chronic kidney disease patients and rat mesangial cells (Ni, Zhong, & Cai, 2016; Zhong, Wei, & Xing, 2014). C. zedoaria , as the sovereign drug in Buxu Xiaozheng recipe, plays an essential role in the therapeutic effects, in which curcumenol, the major bioactive component in Buxu Xiaozheng recipe isolated from C. zedoaria , has been previously reported to possess neuroprotection, anti‐inflammatory and anti‐tumor effects (Lo, Kamarudin, Hamdi, Awang, & Kadir, 2015; Pintatum et al, 2020), and could be safely used in the assessment of potential pharmacokinetic drug interactions (Sun et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

Zhong

Cai

Wei

et al. 2022

The Anatomical Record

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The present work aimed to explore the protective effects of curcumenol and evaluate its pharmacological mechanisms in 5/6 nephrectomy‐induced chronic renal failure (CRF). Rats with CRF were administrated curcumenol and the effects on renal functions were investigated. Renal function examinations were carried out, whereas serum levels of inflammatory mediators, including NF‐κB, MCP‐1 and IL‐1β were analyzed by ELISA. The mRNA expression levels of SIRT1, p65 and IκBα were measured by qRT‐PCR, and the SIRT1 protein levels were analyzed by western blot and immunohistochemistry. Our results indicated that curcumenol significantly improved the renal functions in the CRF rats. Compared to the sham group, serum levels of NF‐κB, MCP‐1, IL‐1β, and the mRNA expression levels of p65 were significantly increased (p < 0.01), whereas the mRNA expression level of IκBα was significantly decreased (p < 0.01) and the SIRT1 levels were dramatically down‐regulated (p < 0.05) in the CRF groups. Treatment with curcumenol remarkably inhibited inflammatory responses as reflected by the reduced levels of inflammatory mediators (p < 0.01) and SIRT1 up‐regulation (p < 0.05). Our findings suggested that curcumenol could improve the renal function in 5/6 nephrectomy‐induced CRF rats, and the mechanisms might involve suppressing the associated inflammation and modulating the SIRT1 and NF‐κB signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

Zhong

Cai

Wei

et al. 2022

The Anatomical Record

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“…[11] The combination of TKSB therapy with Western medicine (WM) can decrease serum creatinine (SCr) and blood urea nitrogen (BUN) and regulate the levels of Ca, P, and PTH. For example, Zheng et al (2012) [12] found that Yishen Jiangzhuo Granule, an effective TCM for TKSB, could significantly improve renal function by decreasing SCr when combined with WM. Zhou (2017) [13] showed that the combination of WM with TKSB therapy could improve the symptoms of kidney failure and reduce bone loss by increasing Ca in blood, reducing P and PTH levels in the blood, increasing bone density, and reducing ALP content.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of randomized controlled trials of tonifying kidney and strengthen bone therapy on nondialysis patients with chronic kidney disease-mineral and bone disorder

Wu¹,

2023

Medicine

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Background: Correction of calcium, phosphorus, and parathyroid hormone disorders is the standard of treatment in nondialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). However, the side effects and adverse reactions are still the main problems. Moreover, the lack of protection of kidney function in the treatment dramatically affects patients' health. Although Traditional Chinese Medicine, specifically tonifying kidney and strengthen bone (TKSB) therapy, is wildly applied to patients with CKD-MBD in China, the evidence of TKSB therapy in the treatment of CKD-MBD is limited. Thus, we conducted this meta-analysis to evaluate the efficacy and safety of TKSB therapy combined with Western medicine (WM) for nondialysis patients with CKD-MBD.Methods: Two investigators conducted systematic research of randomized controlled trials of TKSB therapy for CKD-MBD from 7 electronic databases. Methodological quality evaluations were performed using the Cochrane collaboration tool, and data analysis was conducted by RevMan v5.3 software and STATA v15.0.Results: In total, 8 randomized controlled trials involving 310 patients met the criteria of meta-analysis. The complete results showed that compared with WM alone, TKSB treatment could improve the clinical efficacy rate (risk ratio = 4.

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Effects of Yishenjiangzhuo granules on immunity and bone metabolism in patients with stage 3-4 chronic kidney disease

Abstract: In stage 3-4 CKD patients, B cells and IL-17 participated in the induction of osteoclast activation. YJG could also elevate the level of B cells and decrease their apoptosis, but showed no significant effects on active B cells, IL-17 or osteoclast activity.

Cited by 2 publications

References 9 publications

Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

A meta-analysis of randomized controlled trials of tonifying kidney and strengthen bone therapy on nondialysis patients with chronic kidney disease-mineral and bone disorder

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