Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection: A multicentre, double-blind, and randomised controlled trial

Chen, Yuqin; Liu, Chunli; Wang, Tingping; Qi, Juntong; Jia, Xin; Zeng, Xiansheng; Bai, Jianling; Lu, Wenju; Deng, Yu; Zhong, Bihua; He, Wenjun; Xing, Yue; Zhan, Lian; Zhou, Haohao; Jun-ping, Yan; Yang, Xiaohang; Yu, Hui; Zhou, Jiawei; Zhou, Dansha; Qiu, Lixia; Zhong, Nanshan; Wang, Jian

doi:10.1016/j.jep.2021.114830

Cited by 33 publications

(52 citation statements)

References 14 publications

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“…Among these 40 randomized clinical trials, 33 trials were conducted in China with Chinese herbal medicine; of these, 13 were published in English ( Wang J. B. et al, 2020 ; Xiong W. Z. et al, 2020 ; Xiao et al, 2020 ; An et al, 2021 ; Zhao C. et al, 2021 ; Liu J. et al, 2021 ; Xu X. et al, 2021 ; Zhang X. Y. et al, 2021 ; Hu et al, 2021 ; Luo et al, 2021 ; Ni et al, 2021 ; Zeng et al, 2021 ; Zhou et al, 2021 ), while 20 were published in Chinese ( Jin W. et al, 2020 ; Wang et al, 2020b ; Wang et al, 2020c ; Duan et al, 2020 ; Wang S. et al, 2020 ; Fu et al, 2020 ; Mou et al, 2020 ; Qiu et al, 2020 ; Sun et al, 2020 ; Zhang et al, 2020 ; Chen C. et al, 2021 ; Liu A. et al, 2021 ; Chen Y. et al, 2021 ; Zhao J. et al, 2021 ; Wang Y. et al, 2021 ; He et al, 2021 ; He and Zhang, 2021 ; Ping et al, 2021 ; Ye et al, 2021 ; Zhang, 2021 ). In addition, 3 studies were conducted in Iran ( Karimi et al, 2021 ; Kosari et al, 2021 ; Borujerdi et al, 2022 ), 3 in India ( Majeed et al, 2021 ; Pawar et al, 2021 ; Srivastava et al, 2021 ) and 1 in Ukraine ( Popovych et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

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Background/Aim: Since 2019, the COVID-19 pandemic has been a devastating disease affecting global health to a great extent. Some countries have added on herbal medicines as a complementary treatment for combating COVID-19 due to the urgency of stopping the spread of this viral disease. However, whether these herbal medicines are effective is uncertain. This systematic review and meta-analysis aimed to evaluate the effects of herbal medicine combined therapy in the treatment of COVID-19.Methods: A literature search was performed following the PRISMA Statement and without language restrictions. Seven databases were searched from inception through December 2021. All selected studies were randomized clinical trials (RCTs). Comparing the effects of herbal medicine combined therapy with conventional western medicine, including improvement of clinical symptoms, chest CT images, viral conversion rate, C-reactive protein (CRP) and interleukin 6. Cochrane criteria were applied to examine the methodological quality of the enrolled trials; and meta-analysis software (RevMan 5.4.1) was used for data analysis.Results: In total, the data of 5,417 participants from 40 trials were included in this systematic review; and 28 trials were qualified for meta-analysis. The trials had medium-to-high quality based on GRADE system. Meta-analysis showed that combining herbal medicine vs conventional treatment in 1) coughing (1.43 95% CI:1.21, 1.71, p = 0.0001), 2) fever (1.09 95% CI:1.00, 1.19, p = 0.06), 3) fatigue (1.21 95% CI:1.10, 1.33, p = 0.0001); 4) CT images (1.26 95% CI:1.19, 1.34, P ≤ 0.00001), 5) viral conversion rates (1.22 95% CI:1.06, 1.40, p = 0.005) and 6) viral conversion times (−3.72 95% CI: −6.05, −1.40, p = 0.002), 7) IL6 change (1.97 95% CI: −0.72, 4.66, p = 0.15) and 8) CRP change (−7.92 95% CI: −11.30, −4.53, P ≤ 0.00001).Conclusion: Herbal medicine combined therapy significantly reduces COVID-19 clinical symptoms, improving CT images and viral conversion rates. Reported adverse events are mild. However, for certain biases in the included studies, and the need for further study on effective components of herbal medicine. Further large trials with better randomized design are warranted to definite a more definite role of herbal medicine.

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Section: Resultsmentioning

confidence: 99%

Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

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“…A randomized controlled trial (RCT) that recruited 388 discharged patients with COVID-19 showed that Qingjin Yiqi granules can improve the STC, in the improved scores of the modified Medical Research Council scale (mMRC) and the Borg scale [ 45 ] . An RCT including 131 convalescent patients showed the evidence that Bufei Huoxue capsule improved the attenuation of pneumonia lesions on chest computed tomography (CT), 6-minute walk distance, and fatigue assessment inventory (FAI) scale [ 46 ] . An RCT with 200 cases showed a result that Shumian capsule can improve the STC, such as insomnia, anxiety, and depression [ 47 ] .…”

Section: Interventions For Post Covid-19 Stcmentioning

confidence: 99%

Post COVID-19 burden: focus on the short-term condition

Yang

Pang

Jin

et al. 2022

Acupuncture and Herbal Medicine

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The catastrophic pandemic of the coronavirus disease 2019 has caused serious harm to human life and global social economy. As of June 13, 2022, there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths [1] . During the past 2 years, global studies on prevention and therapies for COVID-19 have achieved a series of promising findings, including antiviral drugs (Remdesivir, Molnupiravir, Paxlovid) and monoclonal antibodies (Bamlanivimab and Etesevimab, Sotrovimab, Casirivimab and Imdevimab) [2] . World Health Organization (WHO) has validated 11 vaccines for the emergency use listing (EUL) [3] . As of June 13, 2022, more than 11.9 billion vaccine doses have been administered worldwide [1] . In China, integrated using of traditional Chinese medicine (TCM) and Western medicine is one of the highlights in fighting COVID-19. "Three formulations and three drugs" (Jinhua Qinggan granules, Lianhua Qingwen capsule, Xuebijing injection, and Qingfei Paidu decoction, Huashi Baidu decoction, Xuanfei Baidu decoction) have been approved by National Medical Products Administration (NMPA) as new drugs or adding indications for COVID-19 [4] . The new drugs and vaccines had become effective weapons in the fight against the pandemic.

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“…Recently, some phytochemicals were studied in COVID patients as complementary treatment options, for example, ginger, traditional Chinese medicine Bufei Huoxue capsules etc. [ 21 , 22 ]. The traditional Chinese herbal medicine therapy, recommended by Chinese herbalists, includes a combination of herbs, based on the distinction of the patient's syndrome.…”

Section: Introductionmentioning

confidence: 99%

Phytovid19: a compilation of phytochemicals research in coronavirus

et al. 2022

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The COVID-19 pandemic has immensely impacted global health causing colossal damage. The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has increased the quest to explore phytochemicals as treatment options. We summarize phytochemicals with activity against various coronaviruses including SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). We compiled 705 phytochemical compounds through text mining of 893 PubMed articles. The physicochemical properties including molecular weight, lipophilicity, and the number of hydrogen bond donors and acceptors were determined from the structures of these compounds. A structure-based evaluation of these properties with respect to drug likeness showed that most compounds have a positive score of drug likeness. QSAR analysis showed that 5 descriptors, namely polar surface area, relative polar surface area, number of hydrogen bond donors, solubility, and lipophilicity, are significantly related to IC50. We envisage that these phytochemicals could be further explored for developing new potential therapeutic molecules for COVID-19. Supplementary Information The online version contains supplementary material available at 10.1007/s11224-022-02035-6.

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Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection: A multicentre, double-blind, and randomised controlled trial

Cited by 33 publications

References 14 publications

Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials

Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials

Post COVID-19 burden: focus on the short-term condition

Phytovid19: a compilation of phytochemicals research in coronavirus

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