Efficacy and safety of colchicine in inflammatory skin diseases: a retrospective, monocentric study in a large tertiary center

Anzengruber, Florian; Graf, Vanessa; Hafner, Jürg; Meienberger, Nina; Guenova, Emmanuella; Dummer, Reinhard

doi:10.1080/09546634.2019.1690621

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…Colchicine is an effective drug for neutrophilic disorders, and we have found it useful in palmoplantar pustulosis, amyloidosis, aphthosis, and vasculitis [Figures 2 - 4 ]. A recent study has used it successfully in aphthosis and leucocytoclastic vasculitis[ 14 ] while other authors have used it for autoinflammatory diseases,[ 15 ] and neutrophilic urticaria. [ 16 ] An overview of the indications is given in the table below [ Table 1 ].…”

Section: Indicationsmentioning

confidence: 99%

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Colchicine in dermatology: Rediscovering an old drug with novel uses

Sardana

Sinha

Sachdeva

2020

Indian Dermatol Online J

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Section: Indicationsmentioning

confidence: 99%

“…Colchicine is effective in this disorder. [ 14 31 ] Colchicine in a dose of 0.5 mg twice daily was administered to 13 patients by Callen et al . [ 32 ] Disease was controlled completely in 9 patients and partial control was observed in 3 patients.…”

Section: Indicationsmentioning

confidence: 99%

Colchicine in dermatology: Rediscovering an old drug with novel uses

Sardana

Sinha

Sachdeva

2020

Indian Dermatol Online J

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“…The AEs are mainly gastrointestinal symptoms, such as vomiting, diarrhea, and nausea, and affect up to 10% of patients treated with the labelled dosage. Other AEs include muscular damage and anagen or telogen effluvium, according to the drug dosage [2][3][4]. Other AEs, such as cardiac arrhythmias, cardiac failure, kidney disease, and myelosuppression are related to the overdosage.…”

Section: Introductionmentioning

confidence: 99%

Colchicine in Managing Skin Conditions: A Systematic Review

et al. 2022

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(1) Background: Colchicine is a natural alkaloid with anti-inflammatory properties used to treat various disorders, including some skin diseases. This paper aims to incorporate all the available studies proposing colchicine as a treatment alternative in the management of cutaneous conditions. (2) Methods: In this systematic review, the available articles present in various databases (PubMed, Scopus-Embase, and Web of Science), proposing colchicine as a treatment for cutaneous pathological conditions, have been selected. Exclusion criteria included a non-English language and non-human studies. (3) Results: Ninety-six studies were included. Most of them were case reports and case series studies describing colchicine as single therapy, or in combination with other drugs. Hidradenitis suppurativa, pyoderma gangrenosum, erythema nodosum, erythema induratum, storage diseases, perforating dermatosis, bullous diseases, psoriasis, vasculitis, acne, urticaria, stomatitis, actinic keratosis, and pustular dermatosis were the main diseases discussed in literature. Although the therapeutic outcomes were variable, most of the studies reported, on average, good clinical results (4) Conclusions: Colchicine could be, as a single therapy or in combination with other drugs, a possible treatment to manage several skin diseases.

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“…The earliest use of colchicine as mitotic inhibitors and for induction of polyploids is reported in 1937 [30,31] and is still popular today in various plant breeding programs [31][32][33]. It is also used for the treatment of Behcet's syndrome [34,35] and Alzheimer disease [36]. It is also reported that crude ethanolic extracts and different fractions showed lower activity (29-61%) against acetylcholinesterase and no activity against urease [37,38].…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Morphological Diversity of Colchicum luteum L., an Economically Important Threatened Medicinal Plant of Kashmir Himalaya

et al. 2022

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Colchicum luteum L. is an economically important and endangered medicinal plant of the Kashmir Himalaya. The corm extract is used for the treatment of rheumatism, gout, Behcet’s syndrome, and Alzheimer disease. It is also used extensively in plant breeding programs for the doubling of chromosomes. The present study was carried out for two years (2017–2019) to study the genetic diversity of C. luteum, an economically important and endangered medicinal plant of Kashmir Himalaya. The mapping of genetic diversity of C. luteum was estimated using Mahalanobis D2 analysis in the Aharbal (Kulgam), Dhara (Theed), and Baera Baal Hills (Harwan) of Kashmir Valley. The results showed the presence of 5 clusters for 30 populations. There were 17 populations in cluster-1, 1 in cluster-2, 2 in cluster-3, 3 in cluster-4, and 7 in cluster-5. The majority of the population was a group in cluster-1 followed by cluster-5. The maximum intracluster distance (D2 values) was observed in cluster-5 (46.55588) followed by cluster-3 (41.61871), and the maximum inter-cluster distance (D2 values) was observed in cluster-3 (46.55588) followed by cluster-5 (41.61871). Our study revealed that plant species possessed sufficient genetic diversity among the populations. Cluster-5 showed superiority in plant−1 respect of the maximum mean plant height (28.46 cm), leaf area (47.0 cm2), number of seeds plant−1 (26.85), corm length (5.15 cm), corm width (3.17 cm), fresh weight of corm plant (6.87 g), and dry weight of corm plant (4.81 g) as compared to other clusters. Out of five clusters, cluster-5 is a promising one for better yield and yield attributing traits. The present study revealed that plant species possessed sufficient genetic diversity among the populations as 30 populations were arranged into 5 clusters. Therefore, cluster-5, consisting of seven populations from the undisturbed area of Harwan, and consequently the populations from the same cluster can be multiplied for initiating a conservation and breeding program and can serve as a tool for the scientific community to evolve better contemporary varieties of C. luteum with profitable characters such as more yield of corms, etc. This will assist farmers, particularly the marginal farmers, to alleviate their income.

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Efficacy and safety of colchicine in inflammatory skin diseases: a retrospective, monocentric study in a large tertiary center

Cited by 8 publications

References 51 publications

Colchicine in dermatology: Rediscovering an old drug with novel uses

Colchicine in dermatology: Rediscovering an old drug with novel uses

Colchicine in Managing Skin Conditions: A Systematic Review

The Assessment of Morphological Diversity of Colchicum luteum L., an Economically Important Threatened Medicinal Plant of Kashmir Himalaya

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