Efficacy and safety of intravenous iron sucrose therapy in a group of children with iron deficiency anemia

Abstract

Background: Iron deficiency anemia is common problem in children, though the oral iron therapy is the main stay of treatment, but most of children not responding to it due to non-compliance. So the parental iron therapy is the treatment of choice for it. Methods: Fifty children between the age group of 1-17 years of age were selected for this study diagnosed as iron deficiency anemia. Iron sucrose given by IV according to their weight and age. CBC performed before starting of study and after receiving Iron sucrose intravenously i.e. after 4, 10 and 30 days of iron sucrose. Results: Among the red cell indices, mean corpuscular volume and mean corpuscular haemoglobin in this study we got mark improvement in both the parameters along with improvement in PCV and finally increase in haemoglobin level. All the parameters having P value highly significant i.e. <0.001 along with minimal side effects. Conclusions: Iron sucrose can be safely used in children.

An assessment for diagnostic and therapeutic modalities for management of pediatric Iron defficiency Anemia in Saudi Arabia: a crossectional study

“…Socio-demographic and professional characteristics of the participants are shown in Table 1. Median age was 39 [28–43] years and 50.3% were Males. Most of the respondents were pediatricians 77(52.4%) and only 6 (4.1%) were associate consultants.…”

“…Another study conducted by Sayyad et al found that administration of the iron sucrose was not associated with serious AEs [46]. Further, iron sucrose and ferric gluconate found to be better than iron dextran in term of higher bio-availability and lower occurrence of anaphylaxis which is considered life-threatening [43]. Consequently, using iron dextran was restricted in the U.S. due to its multiple AEs, such as anaphylactic reactions [47, 48].…”

An assessment for Diagnostic and Therapeutic Modalities for Management of Pediatric Iron Defficiency Anemia in Saudi Arabia: a Cross-sectional Study

“…Another study conducted by Sayyad et al found that administration of the iron sucrose was not associated with serious AEs. 57 Further, iron sucrose and ferric gluconate found to be better than iron dextran in term of higher bio-availability and lower occurrence of anaphylaxis which is considered life-threatening. 58 Consequently, using iron dextran was restricted in the U.S. due to its multiple AEs, such as anaphylactic reactions.…”

“…The responses were evaluated based on published evidence for diagnosis and treatment of IDA. 39,[47][48][49][50][51][52][53][54][55][56][57][58][59][60] An overall score (for diagnosis and treatment, combinedly) was calculated for each participant based on his/her response to all items in the questionnaire. The overall score was 19.…”

An assessment for Diagnostic and Therapeutic Modalities for Management of Pediatric Iron Defficiency Anemia in Saudi Arabia: a Crossectional Study

“…30 Further, iron sucrose and ferric gluconate found to be better than iron dextran in term of higher bio-availability and lower occurrence of anaphylaxis which is considered life-threatening. 46 Consequently, using iron dextran was restricted in the U.S. due to its multiple AEs, such as anaphylactic reactions. 47,48 However, these low proportions of correct answers maybe explained by the fact that most GPs, family physicians, and some pediatricians transfer their patients to a pediatric hematologist in cases of transfusion or IV iron preparation.…”