Efficacy and safety of Qinghua Zhixie Decoction against diarrhea-predominate irritable bowel syndrome

Abstract

Background: Diarrhea-predominant irritable bowel syndrome (D-IBS) is the main subtypes of irritable bowel syndrome (IBS). In recent years, more than half of IBS patients have received complementary and alternative medicine. Traditional Chinese herbal formula is widely used in Asia, and clinical studies have also found that Chinese herbal formula could significantly improve abdominal pain and diarrhea. We plan to carry out a randomized, controlled, double blind, clinical studies to observe the clinical efficacy of Qinghua Zhixie decoction in the treatment of D-IBS. Methods: Four hundred sixty-four participants will be randomly assigned to the treatment group and control group. Patients in both groups would take medications and stimulations simultaneously. The outcomes of IBS symptom severity score, quality of life, psychological states, and recurrence rate will be recorded. Statistics will be analyzed with the SPSS 22.0. Conclusions: The findings of the study will identify the safety and efficacy of Qinghua Zhixie decoction in the treatment of D-IBS. Trial registration: OSF Registration number: DOI 10.17605/OSF.IO/C8MHW.

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

“…Traditional Chinese herbal formulas (CHFs), such as "Sijunzi Tang, Tongxieyaofang, Buzhongyiqi Tang, and Shenlingbaizhu Tang", are widely used for chronic diarrhea therapy in Asia, and clinical studies have also found that CHF could significantly improve abdominal pain and diarrhea in D-IBS and functional diarrhea patients (Gou et al, 2016;Jandhyala, 2015;Ji et al, 2022;Zhou et al, 2019). A growing number of studies have supported the view that Chinese herbal formulas alleviate the symptoms of diarrhea by modulating the fecal microbiota because they inevitably interact with the gut microbiota with poor oral bioavailability (Zu et al, 2018) (Jia et al, 2019;Ma et al, 2020;Qu et al, 2021;Shi et al, 2019).…”

“…A growing number of studies have supported the view that Chinese herbal formulas alleviate the symptoms of diarrhea by modulating the fecal microbiota because they inevitably interact with the gut microbiota with poor oral bioavailability (Zu et al, 2018 ). Qinghua Zhixie decoction (QZD) consists of Fengfei Cao ( Pteris multifida Poir ), Dijin Cao ( Elsholtzia Ciliata Hyland ), Bugu Zhi ( Psoralea corylifolia ), Huanglian ( Coptis chinensis ), Muxiang ( Radix Aucklandiae ), Paojiang ( Baked ginger ), Baishao ( Radix paeoniae alba ), Fangfeng ( Radix Saposhnikoviae ), Cangzhu ( Rhizoma atractylodis ), Baizhu ( Rhizoma Atractylodis Macrocephalae ), and Xianhe Cao ( Agrimonia pilosa ) and can regulate the gut microbiota and reduce 5‐hydroxytryptamine and vasoactive intestinal polypeptides to improve diarrhea (Ji et al, 2022 ). Gegen Qinlian decoction (GD), as a classic prescription for diarrhea with IDHS, is composed of Pueraria lobata ( Willd .)…”

“….Baizhu (Rhizoma Atractylodis Macrocephalae), and Xianhe Cao (Agrimonia pilosa) and can regulate the gut microbiota and reduce 5-hydroxytryptamine and vasoactive intestinal polypeptides to improve diarrhea(Ji et al, 2022). Gegen Qinlian decoction (GD),…”