Efficacy and timing of application of oxathiapiprolin against black shank of flue-cured tobacco

Bittner, Richard; Mila, A. L.

doi:10.1016/j.cropro.2016.10.019

Cited by 18 publications

(16 citation statements)

References 20 publications

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“…It acts via inhibition of a novel molecular target—an oxysterol‐binding protein (OSBP) homolog (FRAC classification F9). It exhibits excellent preventative, curative, and residual efficacy against oomycete diseases . Oxathiapiprolin is authorized as a foliar or soil treatment at planting and for delivery via drip irrigation in North America and several countries in the Pacific, Asia, and Central and South America; authorizations are pending in Europe (Lunn D, http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/Evaluation2016/OXATHIAPIPROLIN.pdf).…”

Section: Introductionmentioning

confidence: 99%

Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR–Cas9 in Phytophthora sojae

Miao

Liu

et al. 2020

Pest Management Science

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BACKGROUND: Oxathiapiprolin is among the first commercial oxysterol-binding protein inhibitors (OSBPIs) developed by DuPont Corporation and shows excellent activity against plant-pathogenic oomycetes. Although more than 21 target site mutations have been identified in insensitive oomycetes, only G770V, G839W, and ΔN837 have been verified to confer oxathiapiprolin resistance in Phytophthora capsici or P. sojae. The effect of other mutations on OSBPIs sensitivity requires urgent investigation. RESULTS: P. sojae transformants containing 16 mutations of PsORP1 were recovered using the CRISPR-Cas9 system. Transformants containing L733W, S768F, S768Y, N837Y, N837F, P861H, L863W, or I877Y showed high oxathiapiprolin resistance, with resistant factors (RFs) > 3000. Point mutations S768K, S768I, G770L, G770P, G770A, ΔG818/F819, N837I, and I877F exhibited low resistance, with RFs < 80. Phenotype assays revealed that the most highly resistant transformants showed enhanced or similar pathogenicity, oospore production, and cyst gemination. However, most transformants displayed decreased sporangia and zoospore production compared with parental wild-type P6497.CONCLUSION: This study demonstrated that L733W, S768F, S768Y, N837Y, N837F, P861H, L863W, and I877Y in PsORP1 confer high oxathiapiprolin resistance in P. sojae.

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Section: Introductionmentioning

confidence: 99%

Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR–Cas9 in Phytophthora sojae

Miao

Liu

et al. 2020

Pest Management Science

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“…Oxathiapiprolin is a piperidinyl-thiazole-isoxazoline fungicide (FRAC code 49) [1,2] with extremely high activity against plant pathogenic oomycetes [3][4][5][6][7][8][9][10][11] except Pythium species [2]. Oxathiapiprolin is effective when applied preventatively or curatively to the foliage or to the root system [12,13] and shows translaminar and acropetally systemic translocation [2,3,5,11].…”

Section: Introductionmentioning

confidence: 99%

Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens

Cohen

2020

PLoS ONE

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Oxathiapiprolin is a fungicide effective against downy mildews of cucumber (Pseudoperonospora cubensis) and basil (Peronospora belbahrii) and late blight of tomato (Phytophthora infestans). To avoid fungicide resistance, it is recommended to apply oxathiapiprolin as a mixture with a partner fungicide that have a different mode of action. Here it is shown that a single application of oxathiapiprolin, benthiavalicarb, or their mixture (3+7, w/w) to the root of nursery plants grown in multi-cell trays provided prolonged systemic protection against late blight and downy mildews in growth chambers and in field tests. Soil application of 1mg active ingredient per plant provided durable protection of up to four weeks in tomato against late blight, cucumber against downy mildew and basil against downy mildew. Not only did the mixture of oxathiapiprolin and benthiavalicarb provide excellent systemic control of these diseases but also mutual protection against resistance towards both oxathiapiprolin and benthiavalicarb.

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“…Others showed efficacy of soil drenches with oxathiapiprolin against black shank in tobacco [ 12 ], Phytophthora root rot in citrus [ 14 ] and Phytophthora blight in bell pepper [ 13 ]. No soil drench tests with the above fungicides were reported for potato.…”

Section: Discussionmentioning

confidence: 99%

“…Soil application of 1mg active ingredient per plant provided durable protection for up to four weeks in tomato against late blight, cucumber against downy mildew and basil against downy mildew. Other researchers demonstrated efficacy of soil drench with oxathiapiprolin against Phytophthora black shank in tobacco [ 12 ] Phytophthora blight in pepper [ 13 ] and Phytophthora root rot in citrus [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A new strategy for durable control of late blight in potato by a single soil application of an oxathiapiprolin mixture in early season

Cohen

Rubin

2020

PLoS ONE

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Root treatment with oxathiapiprolin, benthiavalicarb or their mixture Zorvec-Endavia [ZE (3+7, w/w)] was shown to provide prolonged systemic protection against foliar oomycete pathogens attacking cucumber, tomato and basil. Here we report that these fungicides can effectively protect potato plants against late blight when applied to the soil in which such potato plants are grown. In two field experiments, performed in 2019 and 2020, potato plants grown in 64 L containers were treated with a soil drench of oxathiapiprolin, benthiavalicarb or ZE at 12.5, 25 or 50 mg ai/five plants in a container. Artificial inoculations with Phytophthora infestans revealed that such treated plants were protected against late blight in a dose-dependent manner all along the season. Interestingly, oxathiapiprolin persisted in the treated soil for at least 139 days, providing systemic protection against late blight to the following potato crops grown in that treated soils. Potato plants grown in loess soil in the field were either sprayed or drenched with ZE. Plants treated via the soil were significantly better protected against late blight compared to the plants treated by a spray. The data demonstrate a new strategy for season-long protection of potato against late blight by a single soil application of ZE. The systemic nature of oxathiapiprolin and benthiavalicarb composing ZE assures the translocation to the foliage of two fungicides with different modes of action. This shall minimize the risk of developing resistance against either fungicide in the treated crops.

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Efficacy and timing of application of oxathiapiprolin against black shank of flue-cured tobacco

Cited by 18 publications

References 20 publications

Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR–Cas9 in Phytophthora sojae

Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR–Cas9 in Phytophthora sojae

Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens

A new strategy for durable control of late blight in potato by a single soil application of an oxathiapiprolin mixture in early season

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