Efficacy assessment of antifungal metabolites from Chaetomium globosum No.05, a new biocontrol agent, against Setosphaeria turcica

Zhang, Guizhen; Wang, Fengting; Qin, Jianchun; Wang, Di; Zhang, Jingying; Zhang, Yanhua; Zhang, Shihong; Pan, Hongyu

doi:10.1016/j.biocontrol.2012.10.005

Cited by 61 publications

(40 citation statements)

References 38 publications

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“…Furthermore, Colletotrichum trunctatum isolated from Jatropha curcas was able to control growth of Fusarium oxysporum and Scleorotinia sclerotiorum plant pathogens (Hanada et al 2010;Kumar & Kaushik 2013). Antifungal belong to the cytochalasin family, chaetoglobosin A and chaetoglobosin C produced by endophytic fungi Chaetomium globosum, could suppressed the growth of pathogenic fungi Setosphaeria turcica in maize (Zhang et al 2013). Larkin et al (1996) used endophytic fungi F. oxysporum nonpathogenic to control fusarium wilt of water melon.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Endophytic Fungi from Red Ginger (Zingiber officinale Rosc.) Plant and Their Inhibitory Effect to Fusarium oxysporum Plant Pathogenic Fungi

Ginting

Sukarno

Widyastuti

et al. 2013

HAYATI Journal of Biosciences

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Indonesia has been known as a country with high medicinal plant diversity. One of the most common medicinal plant from Indonesia is red ginger (Zingiber officinale Rosc.). Nevertheless, limited studies of endophytic fungi associated with these medicinal plants are hitherto available. The objectives of this research were to study the diversity of endophytic fungi on red ginger and to analyze their potential as a source of antifungal agent. All parts of plant organs such as leaf, rhizome, root, and stem were subjected for isolation. Fungal identification was carried out by using a combination of morphological characteristic and molecular analysis of DNA sequence generated from ITS rDNA region. Thirty endophytic fungi were successfully isolated from leaf, rhizome, root, and stem of red ginger plant. Antagonistic activity was tested against Fusarium oxysporum, a pathogenic fungus on plants, using an antagonistic assay. Based on this approach, the fungi were assigned as Acremonium macroclavatum, Beltraniella sp., Cochliobolus geniculatus and its anamorphic stage Curvularia affinis, Fusarium solani, Glomerella cingulata and its anamorphic stage Colletotrichum gloeosporoides, Lecanicillium kalimantanense, Myrothecium verrucaria, Neonectria punicea, Periconia macrospinosa, Rhizopycnis vagum, and Talaromyces assiutensis. R. vagum was found specifically on root whereas C. affinis, L. kalimantanense, and M. verrucaria were found on stem of red ginger plant. A. macroclavatum was found specifically in red ginger plant's organ which located under the ground, whereas C. affinis was found from shoot or organ which located above the ground. The antagonistic activity of isolated endophytic fungi against F. oxysporum varied with the inhibition value range from 1.4 to 68.8%. C. affinis (JMbt7), F. solani (JMd14), and G. cingulata (JMr2) had significantly high antagonistic activity with the value above 65%; and R. vagum (JMa4) and C. geniculatus (JMbt9) had significantly low antagonistic activity with the range value 0-10%.

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Section: Introductionmentioning

confidence: 99%

Diversity of Endophytic Fungi from Red Ginger (Zingiber officinale Rosc.) Plant and Their Inhibitory Effect to Fusarium oxysporum Plant Pathogenic Fungi

Ginting

Sukarno

Widyastuti

et al. 2013

HAYATI Journal of Biosciences

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“…In previous reports, Chaetoglobosin A ( 6 ) and C ( 5 ) showed marked inhibitory effects on the fungus Mucor miehei [2]. Chaetoglobosin A ( 6 ) also displayed significant growth inhibitory activity against the fungi Setosphaeria turcica [18], Botrytis cinerea , Sclerotinia sclerotiorum [30], Rhizopus stolonifer , and Coniothyrium diplodiella [31]. Chaetoglobosin V and chaetoglobosin G have been reported to exhibit high antifungal activity against Alternaria solani [26].…”

Section: Resultsmentioning

confidence: 99%

“…To date, about 80 chaetoglobosins have been found from some fungi belonging to the genera Chaetomium [5,6,7], Discosia [8], Cylindrocladium [9], Penicillium [10,11], Calonectria [12], Diplodia [13], and Phomopsis [14], most belonging to the genus Chaetomium . Many of them have been reported to possess diverse bioactivities, including cytotoxicity to tumor cell lines [15,16], anti-HIV [17], antimicrobial [18], phytotoxic activity [19], and so on. Endophytes are fungi or bacteria that live in the healthy tissues of living plants without causing discernible disease to the host [20].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Chaetoglobosins from the Mangrove Endophytic Fungus Penicillium chrysogenum

Huang

Chen

et al. 2016

Marine Drugs

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A novel chaetoglobosin named penochalasin I (1) with a unprecedented six-cyclic 6/5/6/5/6/13 fused ring system, and another new chaetoglobosin named penochalasin J (2), along with chaetoglobosins G, F, C, A, E, armochaetoglobosin I, and cytoglobosin C (3–9) were isolated from the culture of Penicillium chrysogenum V11. Their structures were elucidated by 1D, 2D NMR spectroscopic analysis and high resolution mass spectroscopic data. The absolute configuration of compounds 1 and 2 were determined by comparing the theoretical electronic circular dichroism (ECD) calculation with the experimental CD. Compound 1 was the first example, with a six-cyclic fused ring system formed by the connection of C-5 and C-2′ of the chaetoglobosin class. Compounds 5–8 remarkably inhibited the plant pathogenic fungus R. solani (minimum inhibitory concentrations (MICs) = 11.79–23.66 μM), and compounds 2, 6, and 7 greatly inhibited C. gloeosporioides (MICs = 23.58–47.35 μM), showing an antifungal activity higher than that of carbendazim. Compound 1 exhibited marked cytotoxicity against MDA-MB-435 and SGC-7901 cells (IC50 < 10 μM), and compounds 6 and 9 showed potent cytotoxicity against SGC-7901 and A549 cells (IC50 < 10 μM).

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“…Secondary metabolites of endophytic Fusarium solani (isolated from Taxus baccata) showed significant antifungal activity against three postharvest pathogens, Fusarium oxysporum, Aspergillus niger and Rhizopus stolonifer (Tayung et al 2010). Similarly, secondary metabolites of Chaetomium globosum inhibited mycelial growth and conidial germination of Setosphaeria turcica and culture filtrates (20 %) completely suppressed disease incidence of northern corn leaf blight (Zhang et al 2013). Likewise, the microbial metabolites have been used as an effective way of plant mutation selection or breeding in both the fertile plants like garlic (Zhang et al 2012), tomato (Zhang et al 2000), eggplant (Zhao et al 2006), sunflower (Rao and Ramgoapl 2010), Pelargonium graveolens plants (Saxenaa et al 2008), Citrus jambhiri (Savita et al 2011) and the sterile or asexual propagated plants such as potato (Cheng and Xing 2005), sugarcane (Sengar et al 2009) and chrysanthemum .…”

Section: Discussionmentioning

confidence: 97%

Efficiency assessment of the antifungal metabolites from Sclerotium cepivorum against onion white rot disease

et al. 2015

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The inhibitory effects of secondary metabolites of Sclerotium cepivorum against itself were studied both in vitro and in vivo. The highest inhibition of fungal growth and a 98.6 % reduction in the number of sclerotia was obtained with 50 % culture filtrate. No sclerotial germination was observed on media amended with culture filtrates at 10, 25 and 50 %. Methanol extract of mycelia and sclerotia, and ethyl acetate extract of culture filtrate both exhibited over 90 % inhibition of S. cepivorum growth at 1200 ppm. A chloroform extract of culture filtrate resulted in 71.1 % inhibition at 1200 ppm. All extracts completely suppressed the formation and germination of sclerotia at 400, 800 and 1200 ppm. In greenhouse experiments, no disease was observed with the ethyl acetate extract when onion seedlings were dipped in the extract for 4 or 8 h. The GC-MS analysis revealed 28 compounds in the methanol extract. The methanol extract contained mainly hexadecanoic acid methyl ester (31.16 %), whereas 5-hydroxymethylfurfural, HMF, (36.40 %) was the main constituent of the ethyl acetate extract. These results suggest that the secondary metabolites of S. cepivorum are potential and promising antifungal agents for the control of onion white rot. These results can be also applied to reduce the incidence and severity of other diseases in different crops.

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Efficacy assessment of antifungal metabolites from Chaetomium globosum No.05, a new biocontrol agent, against Setosphaeria turcica

Cited by 61 publications

References 38 publications

Diversity of Endophytic Fungi from Red Ginger (Zingiber officinale Rosc.) Plant and Their Inhibitory Effect to Fusarium oxysporum Plant Pathogenic Fungi

Diversity of Endophytic Fungi from Red Ginger (Zingiber officinale Rosc.) Plant and Their Inhibitory Effect to Fusarium oxysporum Plant Pathogenic Fungi

Bioactive Chaetoglobosins from the Mangrove Endophytic Fungus Penicillium chrysogenum

Efficiency assessment of the antifungal metabolites from Sclerotium cepivorum against onion white rot disease

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