Efficacy of allogeneic cord blood platelet gel on wounds of dystrophic epidermolysis bullosa patients after pseudosyndactyly surgery

Abstract

Epidermolysis bullosa (EB) is a rare genetic disorder characterized by the formation of blisters and wounds in skin and mucous membranes; it is classified into four types and has various methods of treatment. Management of previous wounds and prevention of formation of new lesions are the most important strategies in the course of therapy to improve patient's quality of life; lack of wound management can lead to further complications such as infection. The current study investigated the therapeutic effects of allogeneic platelet gel (prepared from umbilical cord blood) in a group of children diagnosed with dystrophic epidermolysis bullosa (DEB) eligible for surgical correction of pseudosyndactyly in the hand. The post‐surgical clinical outcome in this group was compared with the clinical outcomes of DEB patients receiving the standard treatment (paraffin gauze wound dressing and topical antibiotics) after corrective surgery. The current study results showed an increase in the rate of recovery and promotion of tissue granulation, complete wound healing, and a decrease in pain level and treatment period. The application of cord blood platelet gel topical dressing was not a conventional method of treatment in patients with DEB wounds and blisters. However, the current study results demonstrated that this gel dressing could effectively accelerate epithelialization and healing of the wounds and decrease patients' pain and post‐surgical recovery period, which altogether leads to improvements in patients' overall quality of life.

Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain

“…Multicomponent CB Banking using platelets, plasma and red blood cells from a proportion of currently discarded CB units could contribute to increasing the therapeutic value and reducing the financial deficit of public CB banking programs ( Querol et al, 2021 ; Scaradavou, 2021 ). International regulatory harmonization and multicenter, large laboratory and clinical studies with sufficient statistical power are necessary to support the preliminary evidences reported in the literature ( Bhattacharya et al, 2001 ; Bhattacharya, 2006 ; Khodabux et al, 2008 ; Khodabux and Brand, 2009 ; Khodabux et al, 2011 ; Hassall et al, 2012 ; Erdem et al, 2014 ; Rosso et al, 2014 ; Versura et al, 2014 ; Yoon, 2014 ; Bianchi et al, 2015 ; Hassall et al, 2015 ; Sharma et al, 2016 ; Piccin et al, 2017a ; Piccin et al, 2017b ; Giannaccare et al, 2017 ; Volpe et al, 2017 ; Bianchi et al, 2018 ; Buzzi et al, 2018 ; Campos et al, 2018 ; Gelmetti et al, 2018 ; Neema, 2018 ; Sarin et al, 2018 ; Sindici et al, 2018 ; Teofili et al, 2018 ; Bianchi et al, 2020 ; Bisceglia et al, 2020 ; Samarkanova et al, 2020c ; Giannaccare et al, 2020 ; González et al, 2020 ; Lopriore et al, 2020 ; Teofili et al, 2020 ; Volpe et al, 2020 ; Samarkanova et al, 2021 ; Torkamaniha et al, 2021 ) and achieve these important goals.…”

Combination of platelet‐rich plasma and platelet gel in treatment of resistance androgenic alopecia: A case series study

“…It now uses in a variety of field like venous ulcers treatment, burn healing, and skin rejuvenation. [10][11][12] The literature has recommended that PRP is effective for androgenic alopecia treatment. 13,14 So in the present study, we used PRP in combination with platelet gel to evaluate the effect of this combination in patients with resistance androgenic alopecia.…”

Selection Criteria of Cord Blood Units for Platelet Gel Production: Proposed Directions from Hellenic Cord Blood Bank. Comment on Mallis et al. Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study. Bioengineering 2019, 6, 66

“…Dear Editor, The content of this article concerns the optimization and standardization of the platelet gel (PG) manual production process which utilizes cord blood (CB). Currently, there exists enough evidence to prove the beneficial effects of CBPG in wound healing applications [1,2]. Wound healing is a dynamic process of cellular events resulting in proper tissue regeneration and skin closure.…”

“…[ 4 ]. Based on the previous literature, CBPG may potentially accelerate and improve the wound healing process [ 1 , 2 , 3 , 4 , 5 , 6 ]. CBPG was used for the first time by Rebulla et al [ 1 , 5 , 6 ] in pediatric patients suffering from extensive skin erosions caused by Epidermolysis bullosa.…”

“…Based on the previous literature, CBPG may potentially accelerate and improve the wound healing process [ 1 , 2 , 3 , 4 , 5 , 6 ]. CBPG was used for the first time by Rebulla et al [ 1 , 5 , 6 ] in pediatric patients suffering from extensive skin erosions caused by Epidermolysis bullosa. Since then, CBPG has been applied with great success in a great number of clinical applications, including spinal reflex recovery [ 7 ], reconstruction of deep surgical sites after cardiothoracic surgery [ 8 ], and diabetic foot ulcer healing [ 9 ].…”