Efficacy of day 4 embryo transfer (ET) in minimizing weekend staffing requirements

Kiltz, R.J.; Woodhouse, D.; Miller, Donna B.; Sciera, A.M.; Corona, Jennifer T.

doi:10.1016/s0015-0282(03)01206-8

Cited by 2 publications

(5 citation statements)

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“…Additionally, in the scope of cross border reproductive care, patients opt to travel abroad or more rarely, they may become unable-for personal reasons-to present to an assisted reproduction unit [40]. Thus, the option of arranging an ET procedure on D4 taking into consideration the patients' requests, even on account of avoiding weekends [6], may provide further flexibility to the demanding schedule of an IVF laboratory [8,18]. Nonetheless, decision making within the context of an IVF laboratory requires data supporting 1 day versus another developmental stage.…”

Section: Discussionmentioning

confidence: 99%

“…Thereafter, full texts were screened seeking for ultimately relevant articles, as well as the reference lists of selected relevant publications were assessed for final inclusion. This thorough screening resulted in a total of 15 studies [5,6,8,13,[17][18][19][20][21][22][23][24][25][26][27] that are employed for the present meta-analysis. In Fig.…”

Section: Search Strategymentioning

confidence: 99%

“…Fifteen studies [5,6,8,13,[17][18][19][20][21][22][23][24][25][26][27] reported results on clinical pregnancy rates per ET cycle. Five different study designs (D4 vs. D3; D4 vs. D5; D4 vs. D2/3; D4 vs. D3/5; D4 vs. D2/3/5) comparing a total of four different days including 11,034 ET cycles were evaluated.…”

Section: Clinical Pregnancy Per Etmentioning

confidence: 99%

“…This has been driven by the numerous advances regarding the assisted reproduction technology (ART) field, namely cryopreservation employing embryo vitrification [1], culture media optimization [2], advances on preimplantation genetic diagnosis (PGD), and testing (PGT) [3], as well as the emergence of techniques focusing on the improvement of the endometrial receptivity [4]. All the novelties evolving may either allow for extension of embryo culture [5] or require extended culture in order for diagnosis to be performed [6]. Hitherto, no consensus seems to be reached on the definitive optimal ET timing [7], due to the uniqueness of each couple's management, rendering the issue of the optimal day for ET a vicious circle [7].…”

Section: Introductionmentioning

confidence: 99%

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Should the flexibility enabled by performing a day-4 embryo transfer remain as a valid option in the IVF laboratory? A systematic review and network meta-analysis

Simopoulou

Sfakianoudis²,

Tsioulou

et al. 2019

J Assist Reprod Genet

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Purpose The present systematic review and network meta-analysis aims to uniquely bring to literature data supporting the true place of the alternative practice of day-4 embryo transfer (D4 ET) in an IVF laboratory, beyond the one-dimensional option of facilitating a highly demanding program. Methods A systematic search was conducted in the databases of PubMed/Medline, Embase, and Cochrane Central Library, resulting to six prospective along with nine retrospective cohort studies meeting eligibility criteria for inclusion. A comparison of D4 ET with day-2 (D2), day-3 (D3), and day-5 (D5) ET, respectively, was performed employing R statistics. Results The sourced results indicate no statistically significant difference regarding clinical pregnancy rates, and ongoing pregnancy/live birth rates stemming from the comparison of D4 with D2, D4 with D3, and D4 with D5 ET, respectively. Additionally, no statistically significant difference could be established in respect to cancelation, and miscarriage rates, following the comparison of D4 with D3 and D4 with D5 ET. Interestingly, we report statistically significant lower preterm birth rates associated with D4 ET, in contrast with D5 ET (RR, 0.19; 95% CI, 0.05-0.67; p value = 0.01). Conclusions The aforementioned results may serve as advocates buttressing the option of D4 ET as a valid candidate in the ET decision-making process. Possible limitations of the current study are the publication bias stemming from the retrospective nature of certain included studies, along with various deviations among studies' design, referring to number and quality of transferred embryos, or different culture conditions referring to studies of previous decades.

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Section: Discussionmentioning

confidence: 99%

Section: Search Strategymentioning

confidence: 99%

Section: Clinical Pregnancy Per Etmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Should the flexibility enabled by performing a day-4 embryo transfer remain as a valid option in the IVF laboratory? A systematic review and network meta-analysis

Simopoulou

Sfakianoudis²,

Tsioulou

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Kiltz et al (21), in a conference presentation, reported the results of a retrospective study which included 272 day 3, 44 day 4, and 38 day 5 embryo transfers; clinical pregnancy rate after day 4 transfers was higher (but not significantly) compared with day 3 (59.1% vs. 40.1) and lower (but not significantly) compared with day 5 (59.1% vs. 68.4%). Saadat et al (22) reported in another conference presentation the results of a retrospective study including 239 subjects who had a day 4 embryo transfer and 286 who had a day 3 transfer; clinical pregnancy rates were comparable between the two groups (46% and 42%, respectively), but the authors mentioned a remarkable trend toward an increased pregnancy rate after day 4 transfers in younger women (<34 years of age).…”

Section: Figurementioning

confidence: 99%