Efficacy of Inactivation of Human Enteroviruses by Dual-Wavelength Germicidal Ultraviolet (UV-C) Light Emitting Diodes (LEDs)

Abstract

The efficacy of germicidal ultraviolet (UV-C) light emitting diodes (LEDs) was evaluated for inactivating human enteroviruses included on the United States Environmental Protection Agency (EPA)’s Contaminant Candidate List (CCL). A UV-C LED device, emitting at peaks of 260 nm and 280 nm and the combination of 260/280 nm together, was used to measure and compare potential synergistic effects of dual wavelengths for disinfecting viral organisms. The 260 nm LED proved to be the most effective at inactivating the CCL enteroviruses tested. To obtain 2-log10 inactivation credit for the 260 nm LED, the fluences (UV doses) required are approximately 8 mJ/cm2 for coxsackievirus A10 and poliovirus 1, 10 mJ/cm2 for enterovirus 70, and 13 mJ/cm2 for echovirus 30. No synergistic effect was detected when evaluating the log inactivation of enteroviruses irradiated by the dual-wavelength UV-C LEDs.

Systematic evaluating and modeling of SARS-CoV-2 UVC disinfection

“…Other groups have reported 260–270 nm as the most effective wavelength when compared to higher wavelengths (280–300 nm) 64 , 65 , or to the traditional 254 nm 66 . 255 nm UV LEDs had a higher germicidal efficiency when compared to 280 nm and 350 nm 67 .…”

Irradiation by a Combination of Different Peak-Wavelength Ultraviolet-Light Emitting Diodes Enhances the Inactivation of Influenza A Viruses

“…These data suggest that differences in the host responses to H1N1 and avian viruses may be a factor contributing to the subtype sensitivities to UV irradiations. Compared with IAVs and the other viruses, including MS2 coliphage, human adenovirus type 2 and human enteric viruses showed a lower sensitivity to the virucidal effect, by 260 nm or 280 nm UV-LED irradiation, respectively, than IAVs [19,28,41]. These data suggest that the sensitivities of various virus species and subtypes to UV-LED irradiation are different, and thus other strategies of UV-LED irradiation are necessary to inactivate UV-resistant subtypes.…”

Woven-Fiber Microfiltration (WFMF) and Ultraviolet Light Emitting Diodes (UV LEDs) for Treating Wastewater and Septic Tank Effluent

“…With this RED, we could then estimate the log reduction of enteric pathogens, including adenovirus, coxsackievirus, and poliovirus, for the UV LED flow-through reactor. Given the published dose response data of these organisms to UV LEDs with the same wavelength emission (peak = 276.6 nm; FWHM = 9.8 nm), using Equation (3) below, we could estimate the inactivation credits (Table 4) [43,62]. It is important to note that the UV LED reactor is scalable, and the combined variable approach allows us to estimate the log reduction for a reactor with the same configuration for a given UV LED output, flow rate, and UV absorbance.…”