Efficacy of ivermectin controlled‐release capsules for the control and prevention of nasal bot infestations in sheep

Rugg, Douglas; Rp, Gogolewski; Barrick, R.A.; Js, Eagleson

doi:10.1111/j.1751-0813.1997.tb13828.x

Cited by 17 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Development of controlled-release technology for the treatment of internal and external parasites of ruminants has important implications for future management of livestock diseases. Such devices combine ease of application with an extended period of protection against a range of internal 29,30 and external 31,32 parasites. They could be expected therefore to gain widespread acceptance among livestock producers, largely because of the need to treat animals less frequently, which in turn leads to savings in labour and animal stress.…”

Section: Scientificmentioning

confidence: 99%

The development and survival of three species of coprophagous insect after feeding on the faeces of sheep treated with controlled‐release formulations of ivermectin or albendazole

Holter

Longstaff

2001

Aust Veterinary J

View full text Add to dashboard Cite

Faeces from sheep treated with albendazole had no detectable effects on breeding by either flies or beetles. In contrast, faeces voided by sheep treated with controlled-release capsules of ivermectin (CRI) precluded successful breeding by each of the species tested. No fly larvae and almost no beetle larvae survived in faeces collected up to 39 days after capsule administration. Newly-emerged O taurus also suffered significant mortality whereas those that survived underwent delayed sexual maturation. Ivermectin residues had no effect on the survival of sexually mature beetles, but reduced the fecundity of O taurus. A model simulating the effects of drug residues on dung beetle populations indicates that CRIs have the potential to cause substantial declines in beetle numbers, particularly if treatment coincides with spring emergence.

show abstract

Section: Scientificmentioning

confidence: 99%

The development and survival of three species of coprophagous insect after feeding on the faeces of sheep treated with controlled‐release formulations of ivermectin or albendazole

Holter

Longstaff

2001

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

“…Ivermectin can be used to kill nematodes and other endoparasites with an effect of 94-100% (1,2). It also has a good killing effect on the larvae of Gastrophilus intestinalis, Oestrus ovis, and the other ectoparasites, such as Psoroptidae, Linognathidae Enderlein, Sarcoptes scabiei, Haematopinus suis in bovine, ovis and swine (3)(4)(5). It is a safe and ideal drug for repelling endoparasites and ectoparasites, which is the most widely used in animal production.…”

Section: Introductionmentioning

confidence: 99%

14-Day Repeated Intraperitoneal Toxicity Test of Ivermectin Microemulsion Injection in Wistar Rats

Dong

Shou-ye²,

Zhang

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

To evaluate the safety of ivermectin microemulsion injection, 100 Wistar rats were injected intraperitoneally at 0.38 g/kg, 0.19 g/kg, and 0.1 g/kg for 14 days. The 14-day repeated toxicity test of ivermectin microemulsion injection was systematically evaluated by clinical observation, organ coefficient, hematological examination, clinical chemistry examination, and histopathological examination. The results showed that no rats died during the test. At the initial stage of treatment, the rats in the high dose group had mild clinical reaction, which disappeared after 4 days. Clinical chemistry showed that the high dose of ivermectin microemulsion could cause significant changes in ALT and LDH parameters in male rats; high and medium doses could increase the liver coefficients of male and female rats. The toxic target organ may be the liver as indicated by histopathological findings. No significant toxic injury was found in the heart, liver, spleen, lung, kidney, brain, ovary, and testes of all groups of rats. No drug-related toxic effects were found at low doses, and thus the NOVEL of ivermectin microemulsion injection was 0.19 g/kg.

show abstract

“…Ivermectin (IVM) is a semi-synthetic member of the avermectin drug family, a series of 16-membered lactone endectocides first isolated from Streptomyces avermetilis in 1975 [ 3 ]. It is commonly used in humans, livestock and pets to control endoparasites, including parasitic helminths such as Onchocerca volvulus [ 4 , 5 ], Haemonchus contortus [ 6 ] and Dirofilaria immitus [ 7 ], and ectoparasites including scabies mites [ 8 ], bot flies and ticks [ 9 , 10 ]. Due to IVM’s strong safety profile in humans [ 11 ] and the fact that adverse reactions are rare and generally mild [ 12 , 13 ], it is distributed to entire communities in mass drug administrations (MDA) once or twice per year for control of onchocerciasis and lymphatic filariasis in Africa.…”

Section: Introductionmentioning

confidence: 99%

Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals

Seaman¹,

Alout²,

Meyers³

et al. 2015

BMC Genomics

View full text Add to dashboard Cite

BackgroundIvermectin has been proposed as a novel malaria transmission control tool based on its insecticidal properties and unique route of acquisition through human blood. To maximize ivermectin’s effect and identify potential resistance/tolerance mechanisms, it is important to understand its effect on mosquito physiology and potential to shift mosquito population age-structure. We therefore investigated ivermectin susceptibility and gene expression changes in several age groups of female Anopheles gambiae mosquitoes.MethodsThe effect of aging on ivermectin susceptibility was analyzed in three age groups (2, 6, and 14-days) of colonized female Anopheles gambiae mosquitoes using standard survivorship assays. Gene expression patterns were then analyzed by transcriptome sequencing on an Illumina HiSeq 2500 platform. RT-qPCR was used to validate transcriptional changes and also to examine expression in a different, colonized strain and in wild mosquitoes, both of which blood fed naturally on an ivermectin-treated person.ResultsMosquitoes of different ages and blood meal history died at different frequencies after ingesting ivermectin. Mortality was lowest in 2-day old mosquitoes exposed on their first blood meal and highest in 6-day old mosquitoes exposed on their second blood meal. Twenty-four hours following ivermectin ingestion, 101 and 187 genes were differentially-expressed relative to control blood-fed, in 2 and 6-day groups, respectively. Transcription patterns of select genes were similar in membrane-fed, colonized, and naturally-fed wild vectors. Transcripts from several unexpected functional classes were highly up-regulated, including Niemann-Pick Type C (NPC) genes, peritrophic matrix-associated genes, and immune-response genes, and these exhibited different transcription patterns between age groups, which may explain the observed susceptibility differences. Niemann-Pick Type 2 genes were the most highly up-regulated transcripts after ivermectin ingestion (up to 160 fold) and comparing phylogeny to transcriptional patterns revealed that NPCs have rapidly evolved and separate members respond to either blood meals or to ivermectin.ConclusionWe present evidence of increased ivermectin susceptibility in older An. gambiae mosquitoes that had previously bloodfed. Differential expression analysis suggests complex midgut interactions resulting from ivermectin ingestion that likely involve blood meal digestion physiological responses, midgut microflora, and innate immune responses. Thus, the transcription of certain gene families is consistently affected by ivermectin ingestion, and may provide important clues to ivermectin’s broad effects on malaria vectors. These findings contribute to the growing understanding of ivermectin’s potential as a transmission control tool.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-015-2029-8) contains supplementary material, which is available to authorized users.

show abstract

Efficacy of ivermectin controlled‐release capsules for the control and prevention of nasal bot infestations in sheep

Abstract: Treatment with a single ivermectin controlled release capsule was 100% effective against existing infestations of O ovis and as a prophylactic treatment for this parasite.

Cited by 17 publications

References 5 publications

The development and survival of three species of coprophagous insect after feeding on the faeces of sheep treated with controlled‐release formulations of ivermectin or albendazole

The development and survival of three species of coprophagous insect after feeding on the faeces of sheep treated with controlled‐release formulations of ivermectin or albendazole

14-Day Repeated Intraperitoneal Toxicity Test of Ivermectin Microemulsion Injection in Wistar Rats

Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals

Contact Info

Product

Resources

About