Efficacy of locally‐delivered doxycycline microspheres in chronic localized periodontitis and on <i>Porphyromonas gingivalis</i>

Rao, Sampath K.; Setty, Swati; Acharya, Anirudh B.; Thakur, Srinath

doi:10.1111/j.2041-1626.2011.00110.x

Cited by 22 publications

(13 citation statements)

References 37 publications

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“…Depending on the severity of disease and architecture of the resulting bone loss, periodontitis has traditionally been treated nonsurgically, by osteoplasty and/or ostectomy combined with ablation of the periodontal pocket, by regenerative surgery or using a combination of methods (48,64,196,224,340). Nonsurgical therapy generally includes intensive instruction in oral hygiene techniques, scaling and root planing, use of antimicrobial oral rinses and occasionally the local application of an antibiotic or use of a systemic antibiotic (158,164,176,199,295,297,331,394). This form of therapy is most often selected for Charring and pitting of exposed root surface following attempted frenectomy with a diode laser.…”

Section: Rationale For Use Of a Laser In The Treatment Of Periodontitismentioning

confidence: 99%

Lasers and the treatment of periodontitis: the essence and the noise

Cobb¹

2017

Periodontology 2000

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The dental literature contains 25 years of accumulated reports and clinical studies addressing the utility of lasers in the treatment of periodontitis, both as a monotherapy or as an adjunct to surgical and nonsurgical therapy. Yet, the evidence from the 118 human clinical studies cited in this narrative review remains conflicted and insufficient to suggest that integration of a laser in a periodontal treatment protocol will provide antimicrobial and healing outcomes superior to those achieved by traditional therapy. When viewed as a collective body of evidence, it becomes apparent that a majority of the studies are underpowered and exhibit significant heterogeneity in design. Furthermore, the collected studies report a varied choice of parameters, even within the same wavelength of laser. There is little uniformity between studies in the reporting of measured clinical parameters. Most studies reported 3- and/or 6-month post-treatment results; however, the range of time intervals includes studies reporting results from 1 week to up to 1-12 months or longer. Lastly, many studies were considered at risk for bias as a result of a lack of examiner masking and/or calibration. There is great need for well-designed, highly controlled multicenter clinical trials that are adequately powered in terms of subject enrollment, that use similar protocols in terms of laser parameters and that report measureable outcomes in a uniform manner. Without such studies, the questions surrounding the use of lasers in the treatment of periodontal disease will persist.

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Section: Rationale For Use Of a Laser In The Treatment Of Periodontitismentioning

confidence: 99%

Lasers and the treatment of periodontitis: the essence and the noise

Cobb¹

2017

Periodontology 2000

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“…Sample size calculation was determined based on statistical power analysis using http://biomath. info/power built up on previous study (9) . A total sample size of twenty patients (ten in each of the two groups).…”

Section: Sample Sizementioning

confidence: 99%

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

et al. 2019

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Purpose:The current study was directed to estimate the role of porphoromonas gingivalis in the relation between rheumatoid arthritis and periodontitis by using subantimicrobial dose doxycycline. Subjects and methods: The current study was accomplished on twenty patients who had mild or moderate chronic periodontitis and rheumatoid arthritis they were partitioned into two groups: Group I; ten patients were exposed to mechanical debridement only and Group II: ten patients were exposed to mechanical debridement added to receiving small dose doxycycline (SDD) as a host modulatory agent (20mg twice daily) for three months. Results: group I exhibited a greatly significant improvement in clinical parameter in correlation to group II after three months follow up. Group II showed the statistically significantly lowest percentage decrease in number of bacteria in synovial fluid Conclusion: The adjunct use of doxycycline as host modulatory agent improved the treatment outcomes when used with mechanical debridement in rheumatoid arthritis and patients with periodontitis. Codex : 45/1907 azhardentj@azhar.edu.eg

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“…[28] Two other studies have investigated further controlled release systems of doxicycline. [29,30] One study compared doxicycline "biodegradable implants" (polymer fi lms based on poly-epsiloncaprolactone dissolved in dichloromethane and carbopol containing 60 mg of doxycycline hyclate) with a gel containing 25 mg of doxycycline which in contact with the GCF, allows a controlled release of the drug. [29] Thirty patients with chronic periodontitis with residual pockets greater than or equal to 5 mm were divided into three groups 2 weeks after causal therapy: The fi rst group received the application of doxycycline gel, the second the biodegradable implants, and the third only SRP.…”

Section: Patianna and Valentementioning

confidence: 99%

“…Another study, however, has fi rst tested in vitro, and then in vivo, the effi cacy of the microspheres of doxycycline in patients with chronic periodontitis. [30] Fourteen patients were randomly assigned to two groups of 7 patients each. All patients received one session of SRP in full mouth; the control group received the application of microspheres doxycycline only at baseline, while the group tests at baseline, at 1 month and 3 months.…”

Section: Patianna and Valentementioning

confidence: 99%

The adjunctive use of locally delivered tetracyclines in periodontal therapy: A narrative review of the recent literature

Patianna¹,

Valente²

2015

IDJAR

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Antibiotics belonging to the category of tetracyclines have been widely used in periodontal therapy due to their specifi c characteristics that makes them eff ective both against the microorganisms responsible of the periodontal disease and against the enzymatic products responsible of the periodontal breakdown. A search of the recent literature (January 2009-December 2014) was conducted in order to make a review of the use of tetracyclines for local use in periodontal therapy. From this review we can infer that the use of local tetracyclines brings signifi cant advantages in periodontal therapy. However, to date, it is not possible to establish guidelines on the use of these agents given the heterogeneity in the protocols used in the various studies and the lack of a consensus accepted by the scientifi c community. The local locally delivered tetracyclines is eff ective in the treatment of periodontal disease when used in addition to the mechanical therapy and is particularly eff ective in cases of localized acute lesions or individual sites unresponsive to the causal therapy.

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Efficacy of locally‐delivered doxycycline microspheres in chronic localized periodontitis and on Porphyromonas gingivalis

Abstract: Local drug delivery of doxycycline microspheres significantly improved the treatment outcomes in periodontal pocket therapy and reduced P. gingivalis in the periodontal pocket.

Cited by 22 publications

References 37 publications

Lasers and the treatment of periodontitis: the essence and the noise

Lasers and the treatment of periodontitis: the essence and the noise

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

The adjunctive use of locally delivered tetracyclines in periodontal therapy: A narrative review of the recent literature

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