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Purpose: The present study was conducted to evaluate the effect of topically applied Nigella Sativa (Black Seeds) on osseointegration of delayed dental implant in an effort to improve outcomes of dental implants. Subjects and Methods: The current study was performed on twelve (12) healthy patients that were divided randomly into two groups: Group 1 (Test group) included six (6) patients with delayed implant insertion with the topical use of nigella sativa; Group 2 (Control group) included six (6) patients with delayed implant insertion without the use of nigella sativa. Results: A non-statistically significant difference was recorded in clinical parameters after three and six months follow up in both groups. Test group showed a highly significant increase in its bone density after six months in comparison with control group. Conclusion: The topical use of nigella sativa in delayed dental implant showed an improvement in peri-implant tissues. INTRODUCTION Dental implant is a valuable management approach in complete or partially edentulous patients, playing an important role in orofacial anatomic contour reconstruction, health, function, and esthetic (1,2) .

Purpose: In an attempt to reduce side effects of cancer chemotherapeutic drugs with the use of the natural product such as clove oil, as it considered that natural resources had always been a better supplement than chemicals in drug manufacture and disease treatment especially that chemicals often have hazardous short or long term side effects. The present examination was done to think about the impact of blend of clove oil with 5-fluorouracil versus clove oil with cisplatin in the treatment of head and neck squamous cell carcinoma cell lines. Material and methods: All tested sets were examined to evaluate cytotoxic effect of tested drugs by MTT assay, cell cycle analysis and level of apoptosis by flowcytometery. Result: Cell cycle analysis demonstrated that the combination of cisplatin and clove oil exhibited an increase in the percentage of apoptotic cells during the Pre-G1 phase recording 33.15%, compared to that treated with a mix of clove oil and 5-fluorouracil recording a percentage of apoptotic cells recording 16.12% while in control cells the percentage of apoptotic cells at Pre-G1 phase recording 0.92% (P-value<0.01). And also the combination of cisplatin and clove oil exhibited an increase in the percentage of cell growth arrest during the G2/M phase recording 30.1%, compared to that treated with a combination of clove oil and 5-fluorouracil recording a percentage 22.51% while in control cells the percentage of cell growth arrest at G2/M phase recording 7.11% (P-value < 0.01). Conclusion: The cell cycle analysis demonstrated that the blend of cisplatin and clove oil displayed an expansion in the level of cell development capture amid the G2/M stage contrasted with other tried and it showed an expansion in the level of apoptotic cells amid the Pre-G1 stage contrasted with other tried sets.

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Purpose: The present study was carried out to study the effect of changing the anodization process parameters and investigate the corrosion resistance of the ceramic coating that will be formed on the CP-Ti by anodization method. Materials and Methods:CP-Ti samples of (10mm×10mm×2mm) were used for fabrication of bioceramic coating through anodization process with different parameters using potassium silicate as an electrolyte solution. The samples were characterized using XRD, AT-FTIR. The surface roughness was measured using ESEM and the surface topography was evaluated by SEM. Tafel polarization measurement and electrochemical impedance spectroscopy were used to detect the change in the corrosion resistance after anodization. Results:XRD revealed that the anodized coated samples showed well defined peaks at 2θ of Ti and TiO 2 and shallow peaks of SiO 2 . AT-FTIR showed stretching bands of titania and silica. Regarding the surface roughness results, the anodized coated samples at the optimum conditions had the lowest Ra values while the uncoated (control) group had the highest Ra value. On comparing the results of the surface morphology, the best evenly distributed ceramic coat was formed at the optimum conditions where (the applied voltage =50v, the electrolyte concentration =3% and process duration=60min).The corrosion resistance of the anodized coated samples at the optimum conditions was markedly increased more than that of the uncoated CP-Ti samples. Conclusions: The optimum conditions of the anodization process to get a uniform anodized coating can be achieved when; the applied voltage is 50v, the electrolyte concentration is 3% and the process duration in 60min. Moreover, formation of a bioceramic coating has been shown to be a useful method for improving the corrosion resistance.(318) Rasha M Marzouk, et al.