Efficacy of Nebulised Epinephrine versus Salbutamol in Hospitalised Children with Bronchiolitis

John, BM; Sk, Patnaik; Prasad, PL

doi:10.1016/s0377-1237(06)80107-3

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…A study by Sanchez et al [6] using clinical scores and pulmonary mechanics in bronchiolitis comparing epinephrine and salbutamol had found epinephrine to be superior. A smaller study using only clinical parameters in cases of bronchiolitis was done by the author which showed a benefit of epinephrine over salbutamol [26]. The current study has demonstrated superiority of epinephrine over salbutamol in both bronchiolitis and WARI.…”

Section: Discussionsupporting

confidence: 48%

Comparision of Nebulised Salbutamol and L-epinephrine in First Time Wheezy Children

John¹,

Singh²

2010

Medical Journal Armed Forces India

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Background: Salbutamol is the standard recommendation in bronchial asthma. However, the use of bronchodilators in wheeze associated respiratory infections including bronchiolitis continues to be controversial. The aim of this study was to compare the efficacy of nebulised salbutamol versus epinephrine in 'first time' wheezy children using clinical parameters and airway resistance. Methods: Sixty children between two months to 60 months were recruited, 30 in each treatment group. Children received periodic (0, 20, 40 minutes) doses of either salbutamol (0.15mg/kg with 3ml saline subject to a minimum of 2.5mg) or laevo-epinephrine (1:1000, 0.5ml/kg subject to a max of 2.5ml with 3ml saline) via nebuliser along with oxygen. Changes in heart rate (HR), oxygen saturation (SpO 2 ), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) were assessed along with measurement of airway resistance using interrupter method (Hand held spirometer-Microloop with MicroRint module). Result: The respiratory status was better in the epinephrine group with significant improvement in RR, RDAI score, SpO 2 and fall of airway resistance. There were no significant side effects noted in either group. Conclusion: Nebulised epinephrine is a useful and safe drug for wheezy children and is superior to salbutamol. This needs validation by large multicentric randomized blinded studies. MJAFI 2010; 66 : 9-13

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Section: Discussionsupporting

confidence: 48%

Comparision of Nebulised Salbutamol and L-epinephrine in First Time Wheezy Children

John¹,

Singh²

2010

Medical Journal Armed Forces India

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“…5 Nebulized epinephrine is safe for moderate to severe bronchiolitis and is better than salbutamol. 6 Recently a study concluded that using epinephrine instead of salbutamol could be more effective in the management of the disease. This study showed that mean respiratory rate (52.5±4.9 vs. 50±2.9, P<0.05), oxygen saturation (97.1±1.5 vs. 97.9±0.8, P<0.05), mean heart rate (151.8±10 vs 160.2±10.2, P<0.05) and RDAI score (6.4±1.7 vs. 7.7±1.0, p>0.05) were https://doi.org/10.29309/TPMJ/2020.27.12.4726 significantly different in salbutamol and nebulized adrenaline therapy, respectively for management of bronchiolitis in children.…”

Section: Introductionmentioning

confidence: 99%

Nebulized epinephrine versus salbutamol for the management of children presenting with bronchiolitis: Single Center Study.

Farooq

Maqbool

Aslam

et al. 2020

TPMJ

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Objectives: To compare the outcome of nebulized epinephrine versus salbutamol for the management of children presenting with bronchiolitis. Study Design: Randomized Controlled Trial. Setting: Department of Pediatrics, Federal Government Polyclinic Hospital, Islamabad. Period: 6 month (1st October, 2016 to 1st April, 2017). Material & Methods: Children fulfilled selection criteria were enrolled. Then patients were randomly divided in two groups by using lottery method. In Group A, children received salbutamol. In group B, children received nebulized adrenaline. After 48 hours, children were evaluated for heart rate, respiratory rates, oxygen saturation and Respiratory Distress Assessment Index (RDAI) score. All the information was collected using proforma. Data was analyzed using SPSS version 21. Results: The mean age of children was 10.45±6.70 months in epinephrine group and13.07±6.28 months in salbutamol group. There were 29 (52.7%) males & 26 (47.3%) females in both groups. After 48 hours, mean heart rate was 122.58±4.75bpm with epinephrine while 127.87±4.4.44bpm with salbutamol. Mean respiratory rate was 35.16±3.29bpm with epinephrine while 39.84±3.32bpm with salbutamol. Mean RDAI score was 8.35±1.36 with epinephrine while 10.07±1.37 with salbutamol. Mean oxygen saturation was 85.24±2.74% with epinephrine while 80.38±3.26% with salbutamol. The difference was significant (P<0.05). Conclusion: Thus the nebulized epinephrine was found to be more effective in maintaining heart rate, respiratory rate, oxygen saturation and RDAI score of children as compared to salbutamol.

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Bronchodilators for bronchiolitis

Gadomski

Scribani²

2014

Cochrane Database of Systematic Reviews

253

123

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Efficacy of Nebulised Epinephrine versus Salbutamol in Hospitalised Children with Bronchiolitis

Abstract: Nebulised epinephrine is a useful and safe drug for moderate/severe bronchiolitis and is superior to salbutamol.

Cited by 7 publications

References 22 publications

Comparision of Nebulised Salbutamol and L-epinephrine in First Time Wheezy Children

Comparision of Nebulised Salbutamol and L-epinephrine in First Time Wheezy Children

Nebulized epinephrine versus salbutamol for the management of children presenting with bronchiolitis: Single Center Study.

Bronchodilators for bronchiolitis

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