Meconium aspiration syndrome (MAS) is respiratory distress in a newborn baby caused by the presence of meconium in the tracheobronchial airways. The aspiration of meconium stained amniotic fluid by the fetus can happen during antepartum or intrapartum periods and can result in airway obstruction, interference with alveolar gas exchange, chemical pneumonitis as well as surfactant dysfunction. These pulmonary effects cause gross ventilation-perfusion mismatching. To complicate matters further, many infants with MAS have primary or secondary persistent pulmonary hypertension of the newborn as a result of chronic in utero stress and thickening of the pulmonary vessels. Although meconium is sterile, its presence in the air passages can predispose the infant to pulmonary infection. MAS is essentially a clinical diagnosis and should always be suspected in a child with respiratory distress and meconium-stained amniotic fluid at delivery. Though a known entity for a long time, its management still remains contentious. Intubation and direct tracheal suction is performed when meconium is observed in the amniotic fluid and the infant is not vigorous. Subsequent management involves ventilation, surfactant instillation and lavage, inhaled nitric oxide and high frequency ventilation. The role of steroids continues to be controversial.

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BackgroundThe data about the incidence of hypertension in India is scarce and is lacking about hypertension in young adult patients. We studied the incidence of hypertension in a cohort of young adult male military personnel followed for a long duration.MethodsThe data for this retrospective, observational study was derived from the electronic medical records (EMR) of the male service personnel enrolled between 1990 and 2015. All subjects were recruited before 18 years of age in good health without any disease. Hypertension in young adults was defined as the onset of the disease prior to 45 years of age. We calculated the incidence rates as per person years using appropriate statistical methods.ResultsOur study population includes 51,217 participants (median age 33 years, range 17–54) with a mean follow up of 12.5 years, giving a total observation period of 613,925 person-years (py). During the study period, 360 patients developed hypertension, giving an incidence rate of 58.6 per 100,000 py (95% CI 52.8–64.9). The mean age at the time of diagnosis was 33.5 ± 5.7 years (range 20–45) with 5.6 ± 3.9 years (range 0.3–21 yr) of follow up after the diagnosis. Only 16 patients (4.4%) had associated cardiovascular complications attributable to hypertension.ConclusionOur cohort had low incidence rates of hypertension when compared with other studies from abroad. Active military service may offer protection from the hypertension and associated complications.

Nebulised epinephrine is a useful and safe drug for moderate/severe bronchiolitis and is superior to salbutamol.