Filter cake and Triplex powders from Ethiopia were applied to maize and wheat in the laboratory to determine efficacy against the lesser grain borer, Rhyzopertha dominica (Fabricius) (Coleoptera: Bostrichidae); maize weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae); and rice weevil, Sitophilus oryzae (Linnaeus) (Coleoptera: Curculionidae). These species are major insect pests associated with stored grain in Ethiopia. Efficacy of the two powders was determined by exposing 20 adults of each species to 100 g of maize and wheat treated with 0, 0.3, 0.5, 0.7, 1, 2, 3, 4 and 5 g/kg of filter cake, and 0, 0.5, 0.7, 1, 2, 3, 6, 8 and 10 g/kg of Triplex. Adult mortality was determined 14 d after exposure to untreated and treated grain. Adult progeny production at each species-powder-concentration combination was determined at 42 d. Complete mortality (100%) of R. dominica was achieved on maize treated with 3-5 g/kg of filter cake; however, on maize 100% mortality of S. zeamais, and S. oryzae was not achieved at any of filter cake concentrations. Complete mortality of R. dominica adults was observed on wheat treated with 2-3 g/kg of the filter cake. Complete mortality of S. zeamais and S. oryzae was achieved when adults were exposed to wheat treated with 0.7-3 g/kg of filter cake. Mortality was less than 100% at all Triplex concentrations on maize and wheat for all three species. Adult progeny production of R. dominica was wholly suppressed at filter cake concentrations of 1-5 g/kg on maize, whereas progeny production of S. zeamais and S. oryzae on maize was not entirely suppressed at any of the filter cake concentrations. No progeny of R. dominica was observed on wheat treated with 2-3 g/kg of filter cake. Similarly, progeny production of S. zeamais and S. oryzae was completely suppressed on wheat treated with 3 g/kg of a filter cake. Complete suppression of progeny production of the three species was not achieved at any concentration of Triplex on both maize and wheat. These powders have potential in managing R. dominica, S. zeamais, and S. oryzae infesting maize and wheat.