Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Souza, N A; Lima, Edeltrudes de Oliveira; Guedes, Diego Nunes; Pereira, Fillipe de Oliveira; Souza, Evandro Leite de; Sousa, Frederico Barbosa de

doi:10.1590/s1984-82502010000300013

Cited by 28 publications

(24 citation statements)

References 42 publications

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“…Another mechanism of action of 5FU, results of its conversion into 5-fluorodeoxyuridine monophosphate, a potent inhibitor of the enzyme involved in DNA synthesis and nuclear division (Waldorf and Polak, 1983). There are some studies that refer an increasing resistance to 5FC (Ghannoum and Rice, 1999;Gubbins and Anaissie, 2009;Liu et al, 2009;Souza et al, 2010), and despite several mechanisms of action responsible for 5FC resistance are still not established, they could be related with losses of permease activity or decrease of enzymatic activity responsible for the conversion of 5FC into FMUP. This process was observed in C. glabrata, while mutational losses of one of the pyrimidine salvage enzymes and decrease in UPRTase in a gene dose-dependent manner were observed in C. albicans strains, resistant to 5FC (Ghannoum and Rice, 1999).…”

Section: Current Anti-candida Drugsmentioning

confidence: 99%

Activity of phenolic compounds from plant origin against Candida species

Martins

Barros

Henriques

et al. 2015

Industrial Crops and Products

118

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Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival.Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.

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Section: Current Anti-candida Drugsmentioning

confidence: 99%

Activity of phenolic compounds from plant origin against Candida species

Martins

Barros

Henriques

et al. 2015

Industrial Crops and Products

118

View full text Add to dashboard Cite

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“…It is reported that application of EOs may result in retraction of cytoplasm and interaction of EO components with fungal cell wall (Carmo et al 2008). There also may be interference in enzymatic reactions of cell wall synthesis, which affects fungal growth and morphogenesis (De Billerbeck et al 2001, Souza et al 2010. The fact that structural changes were observed in all fungal isolates tested in this study indicates that O. vulgare EO can affect the morphological development of different Aspergillus species and probably other fungi as well.…”

Section: Morpho-physiological Changesmentioning

confidence: 77%

“…Morpho-physiological changes were documented in all tested isolates in our study, such as lack of sporulation, depigmentation of conidiogenous apparatus and conidia, terminal and intercalar swellings and apical buddings. As a result of O. vulgare EO activity, morphophysiological changes in A. fl avus were showed by Souza et al (2010). Authors reported loss of cytoplasm content, depigmentation and distorted development of hyphae with swellings and apical budding.…”

Section: Morpho-physiological Changesmentioning

confidence: 99%

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Comparison of anti-Aspergillus activity of Origanum vulgare L. essential oil and commercial biocide based on silver ions and hydrogen peroxide

Savković¹,

Stupar²,

Grbić³

et al. 2016

Acta Botanica Croatica

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-The antifungal activities of Origanum vulgare essential oil (EO) and of a biocide based on silver and hydrogen peroxide (Sanosil S003) against seven Aspergillus species isolated from different substrata (stone, brick, silk and paper) of cultural heritage objects in Serbia were evaluated. Microdilution, agar dilution and microatmosphere methods were used to determine minimal fungistatic and minimal fungicidal concentrations (MIC and MFC), and light microscopy to determine structural abnormalities. MIC and MFC values for O. vulgare EO ranged from 0.2 to 5 mg mL −1 and for Sanosil S003 from 5 to 250 mg mL −1 . Aspergillus sp. sect. fumigati was the most susceptible isolate, where MIC and MFC values were achieved at 0.5 mg mL −1 for O. vulgare EO, while MIC and MFC values for Sanosil S003 were achieved at 5 and 10 mg mL −1 , respectively. Morpho-physiological changes were documented in all isolates, including lack of sporulation, depigmentation of conidiogenous apparatus and conidia, and presence of aberrant fungal structures. O. vulgare EO exhibited stronger anti-Aspergillus activity than Sanosil S003, as demonstrated by the higher MIC and MFC values and fewer morpho-physiological changes observed in the tested Sanosil S003 concentrations. O. vulgare EO could be an excellent alternative to commercial biocides, with high potential in the fi eld of cultural heritage conservation.

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“…Likewise, most of the fungi are destructive agents that affect agricultural commodities around the globe (Palm, 2001). This is mainly due to fungi producing biologically active compounds such as mycotoxins that are particularly toxic to several plants and animals (Souza et al, 2010;Wareing, 2014).…”

Section: Introductionmentioning

confidence: 99%