Efficacy of prophylactic tranexamic acid in reducing blood loss during and after caesarean section

Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

“…Up to 75% of PPH cases are caused by uterine atony [12]. However, the cases of mortality due to obstetric haemorrhage are mainly related to other causes of PPH [15]. Uterine atony was found only in 6.4% of cases of maternal death related to obstetric haemorrhage [16].…”

Analysis of the efficacy of prophylactic tranexamic acid in preventing postpartum bleeding: systematic review with meta-analysis of randomized clinical trials

“…Upon reading the abstracts of the 461 remaining results, only 39 studies were qualified for full text reading. Of these, two were excluded for not having or not reporting randomization, 20 , 21 nine for not using placebo in the control group, 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 four for not having or not reporting blinding, 31 , 32 , 33 , 34 five for not reporting neither blinding nor placebo, 35 , 36 , 37 , 38 , 39 one for using TXA as treatment and not as prophylaxis, 40 and one because only the abstract was written in English. 41 Thus, 17 trials were selected to comprise the systematic review, however, one of them could not be part of the meta-analysis, as the volume measurements did not report standard deviation 42 ( Fig.…”