Efficacy of Quercetin on Alveolar Bone Structure of Rats With Induced Diabetes

Abstract

INTRODUCTION:Diabetic osteopenia is the sixth classic complication of Diabetes mellitus. High glucose level is capable of triggering increased oxidative stress which induce osteoblast apoptosis. Quercetin, a powerful natural antioxidant, can protect many organs against oxidative damage, including bone. OBJECTIVES: The present study is designed to investigate the effect of quercetin administration on the alveolar bone in rats with induced diabetes. MATERIALS AND METHODS: Twenty-four adult male rats were divided into three equal groups (8 rats each) as follows: Group I: Control group, Group II: diabetic group (with no treatment), Group III: quercetin treated group (induction of diabetes with oral administration of quercetin dose 100mg/ kg/ day for 12 weeks). Diabetes was induced in group II and group III by a single intraperitoneal injection of Streptozotocin (STZ). After 12 weeks all rats were sacrificed and the mandibles were dissected out and prepared for histological analysis using scanning electron microscope (SEM), and energy dispersive x-ray microanalysis (EDX). RESULTS: In diabetic group, there was significant increase in blood sugar level. Bone surface revealed irregular surface with multiple resorptive pits. Moreover, there was significant decrease in calcium level and increase in phosphorous level while in quercetin group. Both blood sugar level and alveolar bone surface relatively returned back to normal. Also there was slight decrease in calcium and increase in phosphorous in comparison to control group. CONCLUSIONS: Quercetin exerts protective effects on STZ-induced oxidative stress in diabetic rats restoring the architecture of bone.

An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review

“…Results showed increase blood glucose level with an irregular bone surface in the diabetic group, while both blood glucose level and alveolar bone surface returned to normal in quercetin-treated group. This confirms the protective effect of quercetin in restoring bone architecture induced due to diabetes [ 40 ].…”

Assessing the Impact of Urban Expansion on the Urban Environment in Riyadh City (2000–2022) Using Geospatial Techniques

“…Statistical analysis was performed to obtain the Pearson correlation coefficient in order to determine the positive or negative relationship between two variables. The correlation coefficient always falls within the range of (+1) to (−1) [38].…”

Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats

“…Moreover, rutin increases bone density by inhibition of osteoclast activity via inhibition of receptor activator of nuclear factor kappa-Β ligand (RANKL), by decreasing the elevated level of ROS and through inhibition of NF-κB activation [2,64,65]. Supplementation with quercetin and arbutin ameliorates bone loss by reducing bone resorption [25,31,32,[66][67][68] through the suppression of osteoclasts activity and the stimulation of osteoblast activity [69][70][71][72][73]. Hyperoside protects osteoblasts from oxidative stress [74,75], while astragalin stimulates differentiation of osteoblasts [76].…”

“…Having in mind that maintenance of normal glycaemic values and regulation of oxidative stress may prevent the development of osteopenia and osteoporosis [31,32] this study aimed to further assess both the other potential adverse effects if used in high concentrations, as well as the potential osteoprotective activity of the traditionally used polyherbal mixture through evaluation of its effects on the histopathological changes of healthy and diabetic female rats bones.…”