Efficacy of rhBMP-2 Loaded PCL/<i>β</i>-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration

Bae, Eun‐Bin; Park, Keun-Ho; Shim, Jin‐Hyung; Chung, Hun Saeng; Choi, Jae-Won; Lee, Jin-Ju; Kim, Chang-Hwan; Jeon, Hyerin; Kang, Seong-Soo; Huh, Jung-Bo

doi:10.1155/2018/2876135

Cited by 40 publications

(66 citation statements)

References 41 publications

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“…3DP technology has been researched in manufacturing scaffolds with growth factor in conjunction with a surgical guide and template. It is capable of not only reproducing the individual anatomical complexity of a maxillofacial defect but also optimizing functions and mechanical properties through the combination of various materials, stem cells and growth factors 4,7,8 . Several in vivo and in vitro studies involving 3DP, particularly using a polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) combination, have shown the feasibility of scaffolds 9,10 .…”

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confidence: 99%

Efficacy of three-dimensionally printed polycaprolactone/beta tricalcium phosphate scaffold on mandibular reconstruction

Lee

Choi²,

Shim

et al. 2020

Sci Rep

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It has been demonstrated that development of three-dimensional printing technology has supported the researchers and surgeons to apply the bone tissue engineering to the oromandibular reconstruction. In this study, poly caprolactone/beta tricalcium phosphate (PCL/β-TCP) scaffolds were fabricated by multi-head deposition system. The feasibility of the three-dimensionally (3D)-printed PCL/β-TCP scaffolds for mandibular reconstruction was examined on critical-sized defect of canine mandible. The scaffold contained the heterogeneous pore sizes for more effective bone ingrowth and additional wing structures for more stable fixation. They were implanted into the mandibular critical-sized defect of which periosteum was bicortically resected. With eight 1-year-old male beagle dogs, experimental groups were divided into 4 groups (n = 4 defects per group, respectively). (a) no further treatment (control), (b) PCL/β-TCP scaffold alone (PCL/TCP), (c) PCL/β-TCP scaffold with recombinant human bone morphogenetic protein-2 (rhBMP-2) (PCL/TCP/BMP2) and (d) PCL/β-TCP scaffold with autogenous bone particles (PCL/TCP/ABP). In micro-computed tomography, PCL/TCP/BMP2 and PCL/TCP/ ABP groups showed significant higher bone volume in comparison to Control and PCL/TCP groups (P < 0.05). In histomorphometric analysis, a trend towards more bone formation was observed in PCL/TCP/BMP2 and PCL/TCP/ABP groups, but the results lacked statistical significance (P = 0.052). Within the limitations of the present study, 3D-printed PCL/β-TCP scaffolds showed acceptable potential for oromandibular reconstruction.

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confidence: 99%

Efficacy of three-dimensionally printed polycaprolactone/beta tricalcium phosphate scaffold on mandibular reconstruction

Lee

Choi²,

Shim

et al. 2020

Sci Rep

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“…Other associations to β-TCP are: growth factors ( 11 , 35 ) dental pulp stem cells ( 14 , 15 ), with inconsistent results, adipose stem cells ( 19 , 20 ), BMP-2 that did not substantially changed the osteoconductive properties of the biomaterials grafted as compared with TCP alone ( 12 ), BMP-2 in 3D printed polycaprolactone/ β-TCP plus decellularized extracellular matrix with significant improvement ( p <0.01) when compared with controls ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin – An experimental study in rats

Camps‐Font²,

Escoda-Francolí³

et al. 2020

Med Oral

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Background The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. Material and Methods CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). Results 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls ( p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks ( p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % ( p = 0.028) and in mm2 ( p = 0.011), specially at two weeks ( p =0.056). Conclusions Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs. Key words: Bone regeneration, biomaterials, experimental design, histology.

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“…Universally, 3D printing has been applied to produce nearly everything, ranging from buildings to human organs (such as the kidney and the heart) and tissues (bones, muscles, and teeth) [127,129,131,132]. ough its application for printing body parts (3D bioprinting) is in its infancy, it is anticipated to rise astronomically with industry 4.0 movements [133].…”

Section: Big Datamentioning

confidence: 99%

Exponential Disruptive Technologies and the Required Skills of Industry 4.0

Bongomin

Ocen

Nganyi

et al. 2020

Journal of Engineering

149

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The 21st century has witnessed precipitous changes spanning from the way of life to the technologies that emerged. We have entered a nascent paradigm shift (industry 4.0) where science fictions have become science facts, and technology fusion is the main driver. Thus, ensuring that any advancement in technology reach and benefit all is the ideal opportunity for everyone. In this study, disruptive technologies of industry 4.0 were explored and quantified in terms of the number of their appearances in published literature. The study aimed at identifying industry 4.0 key technologies which have been ill-defined by previous researchers and to enumerate the required skills of industry 4.0. Comprehensive literature survey covering the field of engineering, production, and management was done in multidisciplinary databases: Google Scholar, Science Direct, Scopus, Sage, Taylor & Francis, and Emerald Insight. From the electronic survey, 35 disruptive technologies were quantified and 13 key technologies: Internet of Things, Big Data, 3D printing, Cloud computing, Autonomous robots, Virtual and Augmented reality, Cyber-physical system, Artificial intelligence, Smart sensors, Simulation, Nanotechnology, Drones, and Biotechnology were identified. Both technical and personal skills to be imparted into the human workforce for industry 4.0 were reported. The review identified the need to investigate the capability and the readiness of developing countries in adapting industry 4.0 in terms of the changes in the education systems and industrial manufacturing settings. This study proposes the need to address the integration of industry 4.0 concepts into the current education system.

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Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration

Cited by 40 publications

References 41 publications

Efficacy of three-dimensionally printed polycaprolactone/beta tricalcium phosphate scaffold on mandibular reconstruction

Efficacy of three-dimensionally printed polycaprolactone/beta tricalcium phosphate scaffold on mandibular reconstruction

Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin – An experimental study in rats

Exponential Disruptive Technologies and the Required Skills of Industry 4.0

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