Efficacy of switching therapy of luteinizing hormone–releasing hormone analogue for advanced prostate cancer

Abstract

This study was conducted to determine the efficacy of switching therapy with a second-line luteinizing hormone-releasing hormone (LHRH) analogue after prostate-specific antigen (PSA) progression for advanced prostate cancer. We enrolled 200 patients, from December 2005 to September 2013, with nodal positive, metastatic prostate cancer or disease progression after definite treatment receiving continuous LHRH analogue therapy with monthly depot leuprorelin(sc) acetate 3.75 mg/vial (LA) or goserelin acetate(sc) 3.6 mg/vial (GA). If the patients had castration-resistant prostate cancer, the treatment choice of switching therapy (from LA to GA or from GA to LA) prior to starting chemotherapy was given. The LH, testosterone level, and PSA change were recorded. The records showed that there were 127 patients receiving LA as initial ADT therapy, whereas the other 73 patients were in GA therapy. A total of 92 patients received LHRH analogue switching therapy (54 patients switched from LA to GA and 38 switched from GA to LA). The effect of LH and testosterone reduction prior to and after switching therapy was comparable between the two groups, and increased PSA level after 3 months of treatment was seen in both groups (median PSA: 15.7-67.7 ng/mL in the LA to GA group; 15.2-71.4 ng/mL in the GA to LA group). This study concluded that switching therapy for patients with PSA progression after ADT has no efficacy of further PSA response.

Oral exposure of sulpiride promotes the proliferation of Brown‑Norway rat prostates

“…Additionally, Van Coppenolle et al (8) demonstrated that T levels are higher in controls compared with animals treated with sulpiride, which is not congruent with the aforementioned results. Previous studies have indicated that an increase in PRL inhibits gonadotrop-releasing hormone (GnRH) release from the hypothalamus and reduces LH release via a negative feedback regulatory mechanism (54,55). The structure and function of the prostate are influenced by the hypothalamus-pituitary-gonadal axis (56), while tissue growth and hormone secretion are primarily affected by T regulation (57).…”

Comparison of diagnostic value of multi‑slice spiral CT and MRI for different pathological stages of prostate cancer

“…Prostate cancer is a male malignant tumor and its incidence is the highest among all male malignant tumors (11). It has been reported that its incidence in male tumors is 9.7% (12,13). The cause of prostate cancer currently remains unclear (14).…”