Efficacy of topical photodynamic therapy for keratoacanthomas: A case-series of four patients

Farías, Marcelo; Hasson, Ariel; Navarrete, Cristian; Nicklas, Claudia; García-Huidobro, Isidora; González, Sergio

doi:10.4103/0378-6323.93634

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…The data regarding the use of PDT for keratoacanthomas is however scarce and limited to case presentations or case series. While some authors show that PDT could be a good alternative for patients with keratoacanthomas (100,101), other authors suggest that keratoacanthomas could develop after PDT (102,103). Further research is therefore mandatory to support the usefulness of PDT for the treatment of keratoacanthomas.…”

Section: Updates In Pdt In the Treatment Of Other Precancerous Skin Lmentioning

confidence: 99%

Photodynamic therapy: A hot topic in dermato-oncology (Review)

et al. 2019

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Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Data available so far indicate that PDT is a promising treatment method which can be successfully employed in several medical fields including dermatology, urology, ophthalmology, pneumology, cardiology, dentistry and immunology. Numerous authors therefore have studied this technique in order to improve its efficacy. As a result, significant advancement has been achieved with regard to PSs and drug delivery systems. Substantial progress was also obtained with respect to PDT for the treatment of precancerous skin lesions, several authors focusing their efforts on the study of daylight-PDT and on identifying methods of decreasing technique-related pain. This review reports on the most recent findings in PDT, with emphasis on cutaneous precancerous lesions. Contents 1. Introduction 2. Photodynamic therapy-generalities 3. Updates in PDT components 4. Updates in PDT for the management of actinic keratoses 5. Updates in PDT for Bowen's disease and erythroplasia of Queyrat 6. Updates in PDT in the treatment of other precancerous skin lesions: Actinic cheilitis and keratoacanthoma 7. Updates in PDT for lichen sclerosus-a dermatosis with potential for malignant transformation 8. Discussion

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Section: Updates In Pdt In the Treatment Of Other Precancerous Skin Lmentioning

confidence: 99%

Photodynamic therapy: A hot topic in dermato-oncology (Review)

et al. 2019

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“…35 All four lesions disappeared completely, with no recurrence at 3 years and excellent cosmetic outcomes. 35 These cases suggest that MAL-PDT may be a successful treatment option for SCC, but PDT in general has limited use for the treatment of invasive SCC. With the risk of metastatic disease, surgical intervention should remain the first-line option, with PDT or other therapies used for patients in whom surgery is not an option.…”

Section: Bowen's Diseasementioning

confidence: 78%

“…34 A small case series evaluated MAL-PDT in the treatment of keratoacanthomas. 35 These cases suggest that MAL-PDT may be a successful treatment option for SCC, but PDT in general has limited use for the treatment of invasive SCC. 35 These cases suggest that MAL-PDT may be a successful treatment option for SCC, but PDT in general has limited use for the treatment of invasive SCC.…”

Section: Bowen's Diseasementioning

confidence: 99%

Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion

Ross¹,

Cherpelis²,

Lien³

et al. 2013

Dermatologic Surgery

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We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL.

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“…There are several reports showing that red light PDT, using either 5-aminolevulinic acid or methyl-aminolevulinate as the prodrug, can treat solitary 7 or multiple KAs 3 , 4 with reasonable efficacy. However, our case appears to be the first report, to our knowledge, of PDT specifically used in the Grzybowski variant of KA.…”

Section: Discussionmentioning

confidence: 99%

“…As a safe, low-cost alternative to systemic agents for ameliorating the worst lesions, we decided to try photodynamic therapy (PDT) because of its reported efficacy in spontaneous KA. 3 , 4 Red light (635 nm Aktilite, Galderma Laboratories, LP, Forth Worth, TX) at a dose of 60 to 80 J/cm 2 was delivered 2.5 hours after application of 16.8% methyl aminolevulinate cream to her forearms and hands. To minimize severe pain, no occlusion was used.…”

Section: Case Reportmentioning

confidence: 99%