Efficacy of β-caryophyllene for periodontal disease related factors

Yoo, Hyun-Jun; Jwa, Su-Kyung

doi:10.1016/j.archoralbio.2019.02.015

Cited by 18 publications

(8 citation statements)

References 20 publications

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“…Regarding the results obtained in the number of total bacteria through the analysis of the 16s gene, we observed a decrease in the groups administered with BCP. In this regard, we are in agreement with the findings reported by Dahman [ 32 ] and Yoo [ 33 ], where the authors demonstrated the antimicrobial and antifungal activity of BCP and a decrease in bacterial diversity with a more pronounced activity against the gram-positive than against the gram-negative bacteria. We observed this microbial selective modulation in the amount of Bacteroidetes in the present study where, despite the bacterial decrease in the groups with the BCP treatment in conjunction with a standard diet, the expression of Bacteroidetes increased significantly, evidencing a diet-dependent selective mechanism by the BCP.…”

Section: Discussionsupporting

confidence: 93%

β-Caryophyllene: A Therapeutic Alternative for Intestinal Barrier Dysfunction Caused by Obesity

et al. 2022

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Obesity is an excessive accumulation of fat that exacerbates the metabolic and inflammatory processes. Studies associate these processes with conditions and dysregulation in the intestinal tract, increased concentrations of lipopolysaccharides (LPSs) in the blood, differences in the abundance of intestinal microbiota, and the production of secondary metabolites such as short-chain fatty acids. β-Caryophyllene (BCP) is a natural sesquiterpene with anti-inflammatory properties and with the potential purpose of fighting metabolic diseases. A diet-induced obesity model was performed in 16-week-old C57BL/6 mice administered with BCP [50 mg/kg]. A reduction in the expression of Claudin-1 was observed in the group with a high-fat diet (HFD), which was caused by the administration of BCP; besides BCP, the phylaAkkermansia and Bacteroidetes decreased between the groups with a standard diet (STD) vs. HFD. Nevertheless, the use of BCP in the STD increased the expression of these phyla with respect to fatty acids; a similar effect was observed, in the HFD group that had a decreasing concentration that was restored with the use of BCP. The levels of endotoxemia and serum leptin increased in the HFD group, while in the HFD + BCP group, similar values were found to those of the STD group, attributing the ability to reduce these in conditions of obesity.

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Section: Discussionsupporting

confidence: 93%

β-Caryophyllene: A Therapeutic Alternative for Intestinal Barrier Dysfunction Caused by Obesity

et al. 2022

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“…The antibacterial activity of β-Caryophyllene against three periodontal pathogens, P. gingivalis, T. forsythia , and T. denticola , was also studied [ 117 ]. T. forsythia and P. gingivalis growth inhibitions were significant at concentrations of 0.019% and 0.004% and above, respectively.…”

Section: Main Constituents Of Cinnamomum Spp Amentioning

confidence: 99%

Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

Yanakiev

2020

Molecules

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Dental medicine is one of the fields of medicine where the most common pathologies are of bacterial and fungal origins. This review is mainly focused on the antimicrobial effects of cinnamon essential oil (EO), cinnamon extracts, and pure compounds against different oral pathogens and the oral biofilm and the possible effects on soft mouth tissue. Basic information is provided about cinnamon, as is a review of its antimicrobial properties against the most common microorganisms causing dental caries, endodontic and periodontal lesions, and candidiasis. Cinnamon EO, cinnamon extracts, and pure compounds show significant antimicrobial activities against oral pathogens and could be beneficial in caries and periodontal disease prevention, endodontics, and candidiasis treatment.

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“…β--caryophyllene can also eradicate Streptococcus mutans in the oral cavity and block the production of oral biofilms, making it a strong candidate for the prevention of dental caries [14], and improves dental health by inhibiting dental pathogenic bacteria, reducing lipopolysaccharide-induced inflammation, and inhibiting the emission of sulfur gases produced by the bacterium Porphyromonas gingivalis [15].…”

Section: Resultsmentioning

confidence: 99%

GC-MS Analysis of the Active Compound in Ethanol Extracts of White Pepper (Piper nigrum L.) and Pharmacological Effects

Arsana

Juliasih

Widyantari

et al. 2022

Cell. Mol. Biomed. Rep.

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Pepper (Piper nigrum L.) has been utilized since antiquity and is considered the king of spices due to its wide use. This study aims to analyze the active compounds of white pepper through GC-MS and their pharmacological effects. Pepper seeds were extracted using 96% ethanol as solvent by the maceration method. The active compounds in the dry extract were then analyzed by GC-MS. Identification of the active compound was carried out by matching it to the Willey7 Library database. Based on the results chromatogram, is known that there are 127 components of the compound, of which there are 11 main components. Most of the main components are alkaloids and have various pharmacological effects discussed. Piperidine, Caryophyllene, and Ethyl isoallocholate are some of active compounds in ethanol extract. Ethyl iso-allocholate acts as an anti-inflammatory with a strong affinity for the target protein and also acts as an antiviral for SARS-CoV by inhibiting the attachment of the viral genome to target proteins, namely angiotensin-converting enzyme 2 (ACE2) and main protease (MPro).

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Efficacy of β-caryophyllene for periodontal disease related factors

Cited by 18 publications

References 20 publications

β-Caryophyllene: A Therapeutic Alternative for Intestinal Barrier Dysfunction Caused by Obesity

β-Caryophyllene: A Therapeutic Alternative for Intestinal Barrier Dysfunction Caused by Obesity

Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

GC-MS Analysis of the Active Compound in Ethanol Extracts of White Pepper (Piper nigrum L.) and Pharmacological Effects

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