Efficiency of trekrezan in experimental bronchopneumonia in rats

Abstract

Trekrezan in a dose of 25 mg/kg normalized the lymphocyte immune status and produced an energy-stabilizing effect, which manifested in decreased levels of lactate, ADP, and AMP and increased content of pyruvate and ATP in blood lymphocytes and lung tissue of rats with experimental acute bronchopneumonia.

Antioxidant Effect of Polyoxidonium and Metaprot during Bronchopulmonary Inflammation in Rats

“…The present in vitro data do not coincide with the in vivo results demonstrating antioxidant effects for both low and high doses of the examined agents [4].…”

“…All agents were injected intraperitoneally for 5 days in optimal effective dose (ED 50 ) obtained in previous studies [4][5][6]: PO, 0.75 mg/kg and metaprote, 25 mg/kg. In group 2, the rats received physiological solution in corresponding volume.…”

“…In light of this, complex therapy of bronchopulmonary infl ammation should employ drugs with a broad profi le of pharmacological activity that can correct disturbances in the energy metabolism, free radical processes, and immune system and stimulate the adaptive potencies in the organism. In most features, an antihypoxant metaprot and immunomodulator polyoxidonium (PO) meet these requirements.Metaprote possesses the energy stabilizing and antioxidant properties, which are especially needed during hypoxia that develops in parallel with bronchopulmonary diseases [4,9]. PO activates the unspecifi c resistance of the organism and up-regulates the humoral and cellular immunity.…”

“…Metaprote possesses the energy stabilizing and antioxidant properties, which are especially needed during hypoxia that develops in parallel with bronchopulmonary diseases [4,9]. PO activates the unspecifi c resistance of the organism and up-regulates the humoral and cellular immunity.…”

Metabolic effects of trekrezan during adaptation of rats to intermittent hypoxic hypoxia

“…Combined exposure to highaltitude training and administration of pharmacological drugs producing rapid stimulatory effect on adaptive processes can increase and strengthen the effectiveness of physiological procedures increasing the resistance to hypoxia and stabilizing the adaptive response (including that in hypoxia-trained subjects) [7]. Trekrezan (triethylammonium salt of 2-methylphenoxyacetic acid) has antihypoxic, actoprotective, and immunostimulatory properties and, therefore, complies with these requirements [1,3,9].Here we studied the effect of trekrezan on energy metabolism in rats during adaptation to intermittent hypoxic hypoxia. …”