Efficient and green sonochemical synthesis of 3,3-bis(4-(dimethylamino)phenyl)indolin-2-ones

Abstract

A simple, green sonochemical synthesis of 3,3-bis(4-(dimethylamino)phenyl)indolin-2-ones, 2,2-bis(4-(dimethylamino)phenyl)-1H-indene-1,3(2H)-dione, 2,2-bis(4-(dimethylamino)phenyl)acenaphthylen-1(2H)-one and 5-(4-(dimethylamino)phenyl)-5-hydroxypyrimidine-2,4,6(1H,3H,5H)-triones using indium(III) chloride catalyst in aqueous media at room temperature is reported. Good yields, easy workup, short reaction time and the use of water as a solvent that is considered to be relatively environmentally benign are advantages of this new method.

Ultrasonic Methylation of Triethylammonium Thiolate as a Key Strategy for Synthesis of Tetrahydropyrazine‐Containing 2‐Oxindole Scaffold

“…Oxindoles, especially substituted oxindoles at 3‐position have exhibited antibacterial, antiinflammatory, antifungal, antimalarial, antitumor, antimicrobial, and antiviral activities. Moreover, the oxindole framework can be found in many biological and pharmaceutically active compounds and natural products …”