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The simple and efficient diastereoselective synthesis of stable 1,4-diionic organosulfur derivatives by the three-component reaction of dialkyl acetylenedicarboxylates, elemental sulfur, and N-heteroaromatic compounds is reported.

A simple and appropriate procedure for the synthesis of 4,5-dihydro-5-hydroxy-3H-pyrrole-3,3-dicarbonitrile derivatives is reported. The advantages of this method are one-pot conditions, high yield of products, short reaction times, and no need of metal catalyst. The structures are confirmed spectroscopically (IR, 1 H-and 13 C-NMR, and EI-MS) and by elemental analyses. A plausible mechanism for this reaction is proposed (Scheme 2).

a b s t r a c tThe synthesis of 2-(3-(4-(dimethylamino)phenyl)-2-oxoindolin-3-yl)-1H-indene-1,3(2H)-diones as new unsymmetrical oxindoles via a FriedeleCrafts type three-component reaction of 1,3-indandion, N,N-dimethylaniline and isatins in ethanol in the presence of LiClO 4 is reported.

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