The result of collision detection is closely related to the further deformation or cutting action of soft tissue. In order to further improve the efficiency and stability of collision detection, in this paper, a collision detection algorithm of bounding volume hierarchy based on virtual sphere was proposed. The proposed algorithm was validated and the results show that the detection efficiency of the bounding volume hierarchy algorithm based on virtual sphere is higher than that of the serial hybrid bounding volume hierarchy algorithm and the parallel hybrid bounding volume hierarchy algorithm. Different collision detection algorithms were tested and the results show that the collision detection algorithm based on virtual sphere has high detection efficiency and good stability. As the number of triangular patches increased, the advantage was more and more obvious. Finally, the proposed algorithm was applied to two large and medium-sized virtual scenes to implement the collision detection between the vastus lateralis muscle, thigh and surgical instrument. Based on the virtual sphere, the collision detection algorithm of bounding volume hierarchy can implement efficient and stable collision detection in a virtual surgery system. Meanwhile, the algorithm can be combined with other acceleration algorithms (such as the multithread acceleration algorithm) to further improve detection efficiency. models. Detection algorithm should meet the authenticity requirement and fluency requirement, and can implement real-time user interaction. 1 At present, the collision detection algorithm can be divided into two categories, one is based on temporal domain, the other is based on spatial domain. The collision detection algorithm based on temporal domain is divided into static collision detection, constant collision detection and discrete collision detection. [2][3][4] The collision detection algorithm based on spatial domain is divided into collision detection algorithm based on entity space and collision detection algorithm based on image space. 5 In recent years, with the development of research on virtual surgery, the researches on the collision detection of the human tissue model in the virtual scene are gradually increasing. 6 Good simulation results in some research have been achieved.Bournemouth University in the UK has developed a collision detection in a virtual scene with a rectum as an environmental model. They used a geometric projection method to handle the collision, which directly corrected the positions of spheres after a contact was detected. In this method, there was no need to compute the penalty forces and hence the solving process was speeded up.Researchers from Kagawa University in Japan developed a fast collision detection algorithm based on axis-aligned bounding box (AABB) method for the virtual reality training system. In this algorithm, there are two key collision detection areas: Area I: the area around the catheter tip and Area II: the previous collision area. Area I is a dynamic area and it will chang...