2020
DOI: 10.1002/pca.2990
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Efficient extraction and purification of benzo[c]phenanthridine alkaloids from Macleaya cordata (Willd) R. Br. by combination of ultrahigh pressure extraction and pH‐zone‐refining counter‐current chromatography with anti‐breast cancer activity in vitro

Abstract: Introduction Macleaya cordata (Willd) R. Br. (Papaveraceae family) is a well‐known traditional Chinese medicine used to treat muscle pain, inflamed wounds, and bee bites. Benzo[c]phenanthridine alkaloids are the main active ingredients in M. cordata. In this work, sanguinarine and chelerythrine were efficiently extracted and purified by ultrahigh‐pressure extraction (UHPE) technique and pH‐zone‐refining counter‐current chromatography (PZRCCC) from M. cordata. Objective To develop an efficient UHPE method follo… Show more

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Cited by 15 publications
(15 citation statements)
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“…Herein, an efficient technique involving high‐speed countercurrent chromatography (HSCCC) was used for separation of chemical components from P. candollei . HSCCC is liquid–liquid partition‐based separation technique and the advantages of this technique include low solvent consumption and better yield, and this technique is useful in isolating various types of natural products [17–20].…”
Section: Introductionmentioning
confidence: 99%
“…Herein, an efficient technique involving high‐speed countercurrent chromatography (HSCCC) was used for separation of chemical components from P. candollei . HSCCC is liquid–liquid partition‐based separation technique and the advantages of this technique include low solvent consumption and better yield, and this technique is useful in isolating various types of natural products [17–20].…”
Section: Introductionmentioning
confidence: 99%
“…As a liquid-liquid partition chromatography, high-speed countercurrent chromatography (HSCCC) has obvious advantages compared with other chromatographic methods [17][18][19][20][21]. HSCCC can achieve multi-target purification without irreversible adsorption from complex mixtures with high recovery [22][23][24][25][26]. So it is widely used in natural product separation [27][28][29], biochemistry [30][31][32], as well as other fields.…”
Section: Introductionmentioning
confidence: 99%
“…Notably, six coumarins, namely, tomentin ( 1 ), toddalolactone ( 2 ), 5,7,8-trimethoxycoumarin ( 3 ), mexoticin ( 4 ), isopimpinellin ( 5 ), and toddanone ( 6 ), were efficiently separated ( Figure 1 ). Recently, HSCCC has been used to effectively separate a variety of components from plant species [ 23 , 24 , 25 ].…”
Section: Introductionmentioning
confidence: 99%