Efficient osteoblastic differentiation of human adipose-derived stem cells on TiO2 nanoparticles and metformin co-embedded electrospun composite nanofibers

Surface modification of TiO2nanoparticles with organic molecules and their biological applications

“…Among various biomaterials, poly- ε -caprolactone (PCL), an FDA approved biodegradable polyester, has attracted much attention in this field due to its appropriate biocompatibility and mechanical properties. 276 Several works demonstrated that a blend of PCL and gelatin (GEL) can generate a highly biomimetic nanofibrous scaffold with appropriate biodegradability and mechanical stability, and most importantly excellent cytocompatibility. However, PCL/GEL NFs alone are not appropriate for bone regeneration due to the absence of inherent osteoinductive capability.…”

“…In this regard, nanocomposites based on ceramic nanoparticles such as TiO 2 NPs have recently drawn considerable attention as bone substitute materials and injectable pastes to fill defects due to their excellent mechanical properties, high chemical stability, and bioactivity. 276 In this regard, Ahmadi et al employed TiO 2 NPs and metformin (MET)- co -embedded composite electrospun poly- ε -caprolactone/gelatin nanofibers (PCL/GEL NFs) to form scaffolds for the improved osteoblastic differentiation of human adipose-derived stem cells (hADSCs). 276 The results showed an improvement of the mechanical properties of this composite due to the presence of TiO 2 NPs, as well as an enhanced adhesion and growth rate of hADSCs on the nTiO 2 /MET-loaded NFs.…”

“…276 In this regard, Ahmadi et al employed TiO 2 NPs and metformin (MET)- co -embedded composite electrospun poly- ε -caprolactone/gelatin nanofibers (PCL/GEL NFs) to form scaffolds for the improved osteoblastic differentiation of human adipose-derived stem cells (hADSCs). 276 The results showed an improvement of the mechanical properties of this composite due to the presence of TiO 2 NPs, as well as an enhanced adhesion and growth rate of hADSCs on the nTiO 2 /MET-loaded NFs. The nanosurface of TiO 2 NPs and the released metformin could result in a high differentiation capacity toward osteoblasts due to the promoted mineralization content and enhanced expression of osteoblastic markers.…”

Recent advances in the use of inorganic nanomaterials as anti caries agents

“…Because of high biocompatibility, bioactivity, and antibacterial activity, the titanium NPs have potential in dental applications [ 117 , 118 ]. In a study, 1% w/w and 5% w/w TiO 2 NPs incorporated into orthodontic composite used for bonding metal brackets [ 119 ].…”

Facile synthesis of nanofibrous and hollow titania microspheres as drug‐laden cell carriers

“…Titania is one type of the most representative inorganic materials and shows excellent biocompatibility, good osteo-conductivity, and strong catalytic performance. [6][7][8][9] It has been extensively applied for the development of novel bone regenerative materials, drug delivery systems, and antibacterial materials. Different types of titania materials have been synthesized, including titania nanoparticles (TiNPs), 6 titania nanotubes, 7 titania electrospun nanofibers, 8 and titania nanowires (TiNWs).…”