This study examined the effects of a 10-week combined upper and lower limb plyometric training (ULLPT) programs on components of physical performance in young female handball players. Methods: Participants aged 15.8 ± 0.2 years were randomly assigned between the experimental (EG; n = 17) and control (CG; n = 17) groups. Two-way analyses of performance (group × time) assessed changes in handgrip force, back extensor strength; medicine ball throwing, 30-m sprint times, change of direction (CoD) [Modified Illinois test (Illinois-MT)], four jumping tests [squat jump (SJ), countermovement jump (CMJ), CMJ with arms (CMJA) and 5 jump test (5JT), static and dynamic balance, and repeated sprint T-test scores (RSTT)]. Results: After 10 weeks of plyometric training (two sessions per week), group × time interactions showed significant changes in EG relative to CG in right and left handgrip force, back extensor strength and medicine ball throwing [p < 0.001, d = 1.51 (large); p < 0.0001, d = 0.85 (large); p < 0.001, d = 0.90 (large); p < 0.0001, d = 0.52 (medium), respectively]. Group × time interactions also showed improvements of EG relative to CG in sprint times [5 m (p = 0.02, d = 0.80 (large)); 10 m (p < 0.0001, d = 1.00 (large)); 20 m (p = 0.02, d = 1.41 (large)); and 30 m (p = 0.02, d = 2.60 (large))], CoD [Illinois-MT (p < 0.001, d = 1.58 (large))] and jumping [(SJ, CMJ, CMJA, and 5JT, p = 0.001, d = 0.87 (large); p < 0.001, d = 1.17 (large); p < 0.001, d = 1.15 (large); and p = 0.006, d = 0.71 (medium)) respectively]. Further, all RSTT scores (best time, mean time, total time, and fatigue index) improved significantly in the experimental group, with group × time interactions varying between p < 0.001 and p = 0.049 (d value large to medium). However, balance did not differ significantly between EG and CG. Conclusion: We conclude that 10 weeks of ULLPT improved many measures of physical performance in young female handball players.